Pocket-based drug design: Exploring pocket space

AAPS Journal

Volumn 15, Issue 1, 2013, Pages 228-241

  Zheng, Xiliang ^a,c   Gan, Linfeng ^a   Wang, Erkang ^a   Wang, Jin ^a,b  

^a CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY   (China)

^b STONY BROOK UNIVERSITY   (United States)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

computer aided drug design; ISR; pocket; SPA

Indexed keywords

PROTEIN TYROSINE KINASE; RAS PROTEIN;

BINDING AFFINITY; BINDING POCKET; COMPUTER MODEL; DRUG DESIGN; DRUG STRUCTURE; DRUG TARGETING; DRUGGABLE POCKET; MATHEMATICAL ANALYSIS; MOLECULAR DYNAMICS; POCKET SPACE; PROTEIN PROTEIN INTERFACE; PROTEIN STRUCTURE; REVIEW; SCORING SYSTEM;

ADENOSINE TRIPHOSPHATE; ALLOSTERIC SITE; DRUG DESIGN; DRUG DISCOVERY; RAS PROTEINS; SRC-FAMILY KINASES;

EID: 84871940431     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-012-9426-6     Document Type: Review

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