Consequences of telomere shortening during lifespan

Current Opinion in Cell Biology

Volumn 24, Issue 6, 2012, Pages 804-808

  Henriques, Catarina M ^a   Ferreira, Miguel Godinho ^a  

^a INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE;

AGING; APOPTOSIS; CELL AGING; CELL DIVISION; CELL PROLIFERATION; COGNITION; DNA DAMAGE; DYSKERATOSIS CONGENITA; GENOME; GENOMIC INSTABILITY; HUMAN; LIFESPAN; NONHUMAN; PRIORITY JOURNAL; PROGERIA; REVIEW; TELOMERE SHORTENING; WERNER SYNDROME;

AGING; ANIMALS; BIOLOGICAL CLOCKS; CELL AGING; CELL DIVISION; HUMANS; MODELS, ANIMAL; TELOMERASE; TELOMERE; TELOMERE SHORTENING;

ANIMALIA;

EID: 84871933264     PISSN: 09550674     EISSN: 18790410     Source Type: Journal    
DOI: 10.1016/j.ceb.2012.09.007     Document Type: Review

References (45)

1. Prescott J., Wentzensen I.M., Savage S.A., De Vivo I. Epidemiologic evidence for a role of telomere dysfunction in cancer etiology. Mutat Res 2012, 730:75-84.
2. Kaul Z., Cesare A.J., Huschtscha L.I., Neumann A.A., Reddel R.R. Five dysfunctional telomeres predict onset of senescence in human cells. EMBO Rep 2012, 13:52-59.
3. Aubert G., Hills M., Lansdorp P.M. Telomere length measurement-caveats and a critical assessment of the available technologies and tools. Mutat Res 2012, 730:59-67.
4. Sahin E., Depinho R.A. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature 2010, 464:520-528.
5. Sahin E., Depinho R.A. Axis of ageing: telomeres, p53 and mitochondria. Nat Rev Mol Cell Biol 2012, 13:397-404.
6. Bernardes de Jesus B., Vera E., Schneeberger K., Tejera A.M., Ayuso E., Bosch F., Blasco M.A. Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer. EMBO Mol Med 2012.
7. Jaskelioff M., Muller F.L., Paik J.H., Thomas E., Jiang S., Adams A.C., Sahin E., Kost-Alimova M., Protopopov A., Cadinanos J., et al. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature 2011, 469:102-106.
8. Itahana K., Campisi J., Dimri G.P. Mechanisms of cellular senescence in human and mouse cells. Biogerontology 2004, 5:1-10.
9. Wright W.E., Shay J.W. Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology. Nat Med 2000, 6:849-851.
10. de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev 2005, 19:2100-2110.
11. Forsyth N.R., Wright W.E., Shay J.W. Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off again. Differentiation 2002, 69:188-197.
12. Shay J.W., Wright W.E., Werbin H. Defining the molecular mechanisms of human cell immortalization. Biochim Biophys Acta 1991, 1072:1-7.
13. Bodnar A.G., Ouellette M., Frolkis M., Holt S.E., Chiu C.P., Morin G.B., Harley C.B., Shay J.W., Lichtsteiner S., Wright W.E. Extension of life-span by introduction of telomerase into normal human cells. Science 1998, 279:349-352.
14. Ding Z., Wu C.J., Jaskelioff M., Ivanova E., Kost-Alimova M., Protopopov A., Chu G.C., Wang G., Lu X., Labrot E.S., et al. Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases. Cell 2012, 148:896-907.
15. Gomes N.M., Shay J.W., Wright W.E. Telomere biology in Metazoa. FEBS Lett 2010, 584:3741-3751.
16. Gomes N.M., Ryder O.A., Houck M.L., Charter S.J., Walker W., Forsyth N.R., Austad S.N., Venditti C., Pagel M., Shay J.W., et al. Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination. Aging Cell 2011, 10:761-768.
17. Gorbunova V., Seluanov A. Coevolution of telomerase activity and body mass in mammals: from mice to beavers. Mech Ageing Dev 2009, 130:3-9.
18. Kirwan M., Dokal I. Dyskeratosis congenita, stem cells and telomeres. Biochim Biophys Acta 2009, 1792:371-379.
19. Atzmon G., Cho M., Cawthon R.M., Budagov T., Katz M., Yang X., Siegel G., Bergman A., Huffman D.M., Schechter C.B., et al. Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proc Natl Acad Sci U S A 2010, 107(Suppl. 1):1710-1717.
20. Njajou O.T., Cawthon R.M., Damcott C.M., Wu S.H., Ott S., Garant M.J., Blackburn E.H., Mitchell B.D., Shuldiner A.R., Hsueh W.C. Telomere length is paternally inherited and is associated with parental lifespan. Proc Natl Acad Sci U S A 2007, 104:12135-12139.
21. Njajou O.T., Hsueh W.C., Blackburn E.H., Newman A.B., Wu S.H., Li R., Simonsick E.M., Harris T.M., Cummings S.R., Cawthon R.M. Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study. J Gerontol A: Biol Sci Med Sci 2009, 64:860-864.
22. Tsang A.R., Wyatt H.D., Ting N.S., Beattie T.L. hTERT mutations associated with idiopathic pulmonary fibrosis affect telomerase activity, telomere length, and cell growth by distinct mechanisms. Aging Cell 2012, 11:482-490.
23. Yamaguchi H., Calado R.T., Ly H., Kajigaya S., Baerlocher G.M., Chanock S.J., Lansdorp P.M., Young N.S. Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med 2005, 352:1413-1424.
24. Elmore L.W., Norris M.W., Sircar S., Bright A.T., McChesney P.A., Winn R.N., Holt S.E. Upregulation of telomerase function during tissue regeneration. Exp Biol Med (Maywood) 2008, 233:958-967.
25. Anchelin M., Murcia L., Alcaraz-Perez F., Garcia-Navarro E.M., Cayuela M.L. Behaviour of telomere and telomerase during aging and regeneration in zebrafish. PLoS One 2011, 6:e16955.
26. Aubert G., Lansdorp P.M. Telomeres and aging. Physiol Rev 2008, 88:557-579.
27. Sherr C.J., DePinho R.A. Cellular senescence: mitotic clock or culture shock?. Cell 2000, 102:407-410.
28. Kakuo S., Asaoka K., Ide T. Human is a unique species among primates in terms of telomere length. Biochem Biophys Res Commun 1999, 263:308-314.
29. Blasco M.A., Lee H.W., Hande M.P., Samper E., Lansdorp P.M., DePinho R.A., Greider C.W. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 1997, 91:25-34.
30. Lee H.W., Blasco M.A., Gottlieb G.J., Horner J.W., Greider C.W., DePinho R.A. Essential role of mouse telomerase in highly proliferative organs. Nature 1998, 392:569-574.
31. Rudolph K.L., Chang S., Lee H.W., Blasco M., Gottlieb G.J., Greider C., DePinho R.A. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 1999, 96:701-712.
32. Fumagalli M., Rossiello F., Clerici M., Barozzi S., Cittaro D., Kaplunov J.M., Bucci G., Dobreva M., Matti V., Beausejour C.M., et al. Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nat Cell Biol 2012, 14:355-365.
33. Hewitt G., Jurk D., Marques F.D., Correia-Melo C., Hardy T., Gackowska A., Anderson R., Taschuk M., Mann J., Passos J.F. Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence. Nat Commun 2012, 3:708.
34. Armanios M., Alder J.K., Parry E.M., Karim B., Strong M.A., Greider C.W. Short telomeres are sufficient to cause the degenerative defects associated with aging. Am J Hum Genet 2009, 85:823-832.
35. Teplyuk N.M. Near-to-perfect homeostasis: examples of universal aging rule which germline evades. J Cell Biochem 2012, 113:388-396.
36. Prigione A., Fauler B., Lurz R., Lehrach H., Adjaye J. The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells. Stem Cells 2010, 28:721-733.
37. Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965, 37:614-636.
38. Baker D.J., Wijshake T., Tchkonia T., LeBrasseur N.K., Childs B.G., van de Sluis B., Kirkland J.L., van Deursen J.M. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 2011, 479:232-236.
39. Campisi J., Andersen J.K., Kapahi P., Melov S. Cellular senescence: a link between cancer and age-related degenerative disease?. Semin Cancer Biol 2011, 21:354-359.
40. Song Z., Zhang J., Ju Z., Rudolph K.L. Telomere dysfunctional environment induces loss of quiescence and inherent impairments of hematopoietic stem cell function. Aging Cell 2012, 11:449-455.
41. Lengner C.J. iPS cell technology in regenerative medicine. Ann N Y Acad Sci 2010, 1192:38-44.
42. McCormick M., Chen K., Ramaswamy P., Kenyon C. New genes that extend Caenorhabditis elegans' lifespan in response to reproductive signals. Aging Cell 2012, 11:192-202.
43. Mason J.B., Cargill S.L., Anderson G.B., Carey J.R. Transplantation of young ovaries to old mice increased life span in transplant recipients. J Gerontol A: Biol Sci Med Sci 2009, 64:1207-1211.
44. Hsin H., Kenyon C. Signals from the reproductive system regulate the lifespan of C. elegans. Nature 1999, 399:362-366.
45. Durieux J., Wolff S., Dillin A. The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell 2011, 144:79-91.