Microparticles and microscopic structures in three fractions of fresh cerebrospinal fluid in schizophrenia: Case report of twins

Schizophrenia Research

Volumn 143, Issue 1, 2013, Pages 192-197

  Mobarrez, Fariborz ^a   Nybom, Rolf ^b   Johansson, Viktoria ^b   Hultman, Christina M ^b   Wallén, Håkan ^a   Landén, Mikael ^b,c   Wetterberg, Lennart ^b  

^a DANDERYD HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Cerebrospinal fluid; Flow cytometry; Microparticles; Scanning electron microscopy; Schizophrenia

Indexed keywords

CD144 ANTIBODY; CD42A ANTIBODY; CD45 ANTIBODY; CELL ANTIBODY; LACTADHERIN; PHOSPHATIDYLSERINE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD SAMPLING; CASE REPORT; CAUCASIAN; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; MONOZYGOTIC TWINS; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SCHIZOPHRENIA;

ANTIGENS, CD; BLOOD PLATELETS; CELL-DERIVED MICROPARTICLES; FEMALE; FLOW CYTOMETRY; HUMANS; MICROSCOPY, ELECTRON, SCANNING; MIDDLE AGED; PHAGOCYTES; SCHIZOPHRENIA; TWINS, MONOZYGOTIC;

EID: 84871929217     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2012.10.030     Document Type: Article

References (22)

1. Atkin T.A., Brandon N.J., Kittler J.T. Disrupted in schizophrenia 1 forms pathological aggresomes that disrupt its function in intracellular transport. Hum. Mol. Genet. 2012, 21:2017-2028.
2. Båve U., Nybom R., Landén M., Wetterberg L. Micrometer-sized thread-like and/or spherical particles in the first fraction of cerebrospinal fluid in patients with bipolar disorder. Bipolar Disord. 2010, 12(3):298-305.
3. Bechter K. The peripheral cerebrospinal fluid outflow pathway - physiology and pathophysiology of CSF recirculation: a review and hypothesis. Neurol. Psychiatry Brain Res. 2011, 17:51-66.
4. Begley D.J. Brain superhighways. Sci. Transl. Med. 2012, 4(147):147fs29.
5. Doeuvre L., Plawinski L., Toti F., Anglés-Cano E. Cell-derived microparticles: a new challenge in neuroscience. J. Neurochem. 2009, 110:457-468.
6. He M., Kubo H., Morimoto K., Fujino N., Suzuki T., Takahasi T., Yamada M., Yamaya M., Maekawa T., Yamamoto Y., Yamamoto H. Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells. EMBO Rep. 2011, 12:358-364.
7. Huttner H.B., Janich P., Köhrmann M., Jászai J., Siebzehnrubl F., Blümcke I., Suttorp M., Gahr M., Kuhnt D., Nimsky C., Krex D., Schackert G., Löwenbrück K., Reichmann H., Jüttler E., Hacke W., Schellinger P.D., Schwab S., Wilsch-Bräuninger M., Marzesco A.M., Corbeil D. The stem cell marker prominin-1/CD133 on membrane particles in human cerebrospinal fluid offers novel approaches for studying central nervous system disease. Stem Cells 2008, 26(3):698-705.
8. Huttner H.B., Corbeil D., Thirmeyer C., Coras R., Köhrmann M., Mauer C., Kuramatsu J.B., Kloska S.P., Doerfler A., Weigel D., Klucken J., Winkler J., Pauli E., Schwab S., Hamer H.M., Kasper B.S. Increased membrane shedding - indicated by an elevation of CD133-enriched membrane particles - into the CSF in partial epilepsy. Epilepsy Res. 2012, 99:101-106.
9. Iliff J.J., Wang M., Liao Y., Plogg B.A., Peng W., Gundersen G.A., Benveniste H., Vates G.E., Deane R., Goldman S.A., Nagelhus E.A., Nedergaard M. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci. Transl. Med. 2012, 4(147):147ra111.
10. Miller B.H., Zeier Z., Xi L., Lanz T.A., Deng S., Strathmann J., Willoughby D., Kenny P.J., Elsworth J.D., Lawrence M.S., Roth R.H., Edbauer D., Kleiman R.J., Wahlestedt C. MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:3125-3130.
11. Mobarrez F., Antovic J., Egberg N., Hansson M., Jörneskog G., Hultenby K., Wallén H. A multicolor flow cytometric assay for measurement of platelet-derived MPs. Thromb. Res. 2010, 125(3):110-116.
12. Morel N., Morel O., Petit L., Hugel B., Cochard J.F., Freyssinet J.M., Sztark F., Dabadie P. Generation of procoagulant MPs in cerebrospinal fluid and peripheral blood after traumatic brain injury. J. Trauma 2008, 64:698-704.
13. Park D., Tosello-Trampont A.C., Elliott M.R., Lu M., Haney L.B., Ma Z., Klibanov A.L., Mandell J.W., Ravichandran K.S. BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature 2007, 450(7168):430-434.
14. Philip N., Bassett A. Cognitive, behavioural and psychiatric phenotype in 22q11.2 deletion syndrome. Behav. Genet. 2011, 41(3):403-412.
15. Scolding N.J., Morgan B.P., Houston W.A., Linington C., Campbell A.K., Compston D.A. Vesicular removal by oligodendrocytes of membrane attack complexes formed by activated complement. Nature 1989, 339(6226):620-622.
16. Stommel E.W., Graber D., Montanye J., Cohen J.A., Harris B.T. Does treating schizophrenia reduce the chances of developing amyotrophic lateral sclerosis?. Med. Hypotheses 2007, 69:1021-1028.
17. Taylor G.R., Crow T.J., Ferrier I.N., Johnstone E.C., Parry R.P., Tyrrell D.A. Virus-like agent in CSF in schizophrenia and some neurological disorders. Lancet 1982, 2(8308):1166-1167.
18. Tyrrell D.A., Parry R.P., Crow T.J., Johnstone E., Ferrier I.N. Possible virus in schizophrenia and some neurological disorders. Lancet 1979, 1(8121):839-841.
19. Vikerfors A., Mobarrez F., Bremme K., Holmström M., Agren A., Eelde A., Bruzelius M., Antovic A., Wallén H., Svenungsson E. Studies of microparticles in patients with the antiphospholipid syndrome (APS). Lupus 2012, 21(7):802-805.
20. Wetterberg L., Nybom R., Bratlid T., Fladby T., Olsson B., Wigzell H. Micrometer-sized particles in cerebrospinal fluid (CSF) in patients with schizophrenia. Neurosci. Lett. 2002, 329(1):91-95.
21. Wolf P. The nature and significance of platelet products in human plasma. Br. J. Haematol. 1967, 13:269-288.
22. Zachau A.C., Landén M., Mobarrez F., Nybom R., Wallén H., Wetterberg L. Leukocyte-derived microparticles and scanning electron microscopic structures in two fractions of fresh cerebrospinal fluid in amyotrophic lateral sclerosis; a case report. J. Med. Case Rep. 2012, 6:274. 10.1186/1752-1947-6-274.