Patients with lynch syndrome mismatch repair gene mutations are at higher risk for not only upper tract urothelial cancer but also bladder cancer

European Urology

Volumn 63, Issue 2, 2013, Pages 379-385

  Skeldon, Sean C ^a   Semotiuk, Kara ^b   Aronson, Melyssa ^b   Holter, Spring ^b   Gallinger, Steven ^b   Pollett, Aaron ^b   Kuk, Cynthia ^a,b   Van Rhijn, Bas ^a,c   Bostrom, Peter ^a   Cohen, Zane ^b   Fleshner, Neil E ^a   Jewett, Michael A ^a   Hanna, Sally ^a,b   Shariat, Shahrokh F ^d   Van Der Kwast, Theodorus H ^c,e   Evans, Andrew ^e   Catto, Jim ^f   Bapat, Bharati ^b   Zlotta, Alexandre R ^a,b  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d NEW YORK PRESBYTERIAN HOSPITAL   (United States)

^e UNIVERSITY HEALTH NETWORK   (Canada)

^f UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Bladder cancer; Genetic; Lynch syndrome; Microsatellite instability; Mismatch repair; MSH2

Indexed keywords

PROTEIN MLH1; PROTEIN MSH2;

ADULT; AGED; ALTERNATIVE RNA SPLICING; ARTICLE; BLADDER CANCER; CANCER GRADING; CANCER REGISTRY; CANCER RISK; CANCER SCREENING; CONTROLLED STUDY; ESCHERICHIA COLI; EXON; FEMALE; FOLLOW UP; GENE DELETION; GENE MUTATION; GENETIC SCREENING; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HIGH RISK PATIENT; HUMAN; IMMUNOHISTOCHEMISTRY; INTRON; KIDNEY PELVIS CARCINOMA; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; MUTATIONAL ANALYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK ASSESSMENT; SACCHAROMYCES CEREVISIAE; TUMOR LOCALIZATION; UPPER TRACT UROTHELIAL CANCER; URETER CANCER;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, TRANSITIONAL CELL; COHORT STUDIES; DNA MISMATCH REPAIR; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; KIDNEY NEOPLASMS; KIDNEY PELVIS; LYNCH SYNDROME II; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED; MUTS HOMOLOG 2 PROTEIN; NUCLEAR PROTEINS; ONTARIO; REGISTRIES; RISK FACTORS; URETERAL NEOPLASMS; URINARY BLADDER NEOPLASMS;

EID: 84871927868     PISSN: 03022838     EISSN: 18737560     Source Type: Journal    
DOI: 10.1016/j.eururo.2012.07.047     Document Type: Article

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