RUNX-1 and CD44 as markers of resident stem cell derivation in undifferentiated intimal sarcoma of pulmonary artery

Histopathology

Volumn 61, Issue 4, 2012, Pages 737-743

  Vasuri, Francesco ^a   Resta, Leonardo ^b   Fittipaldi, Silvia ^a   Malvi, Deborah ^a   Pasquinelli, Gianandrea ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF BARI   (Italy)

Author keywords

Electron microscopy; Immunohistochemistry; Nestin; RUNX 1; Stem cell; Undifferentiated intimal sarcoma

Indexed keywords

ACTIN; ALPHA SMOOTH MUSCLE ACTIN; CALDESMON; CALPONIN; CD31 ANTIGEN; CD34 ANTIGEN; CYCLIN G2; DESMIN; ENDOGLIN; EPITHELIAL MEMBRANE ANTIGEN; HERMES ANTIGEN; KI 67 ANTIGEN; LEAD; NESTIN; OSMIUM TETRAOXIDE; PLATELET DERIVED GROWTH FACTOR; STEM CELL FACTOR RECEPTOR; THY 1 ANTIGEN; TRANSCRIPTION FACTOR RUNX1; TUMOR MARKER; URANYL ACETATE; WT1 PROTEIN; CD44 PROTEIN, HUMAN; RUNX1 PROTEIN, HUMAN;

ADULT; ARTICLE; CASE REPORT; CELL DIFFERENTIATION; CELL JUNCTION; CELL ULTRASTRUCTURE; DISEASE MARKER; ELECTRON MICROSCOPY; ENDOPLASMIC RETICULUM; ENDOTHELIAL PROGENITOR CELL; FEMALE; HEMATOPOIETIC STEM CELL; HISTOGENESIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG SARCOMA; MALE; PRIORITY JOURNAL; STEM CELL; UNDIFFERENTIATED INTIMAL SARCOMA OF THE PULMONARY ARTERY; INTIMA; METABOLISM; PATHOLOGY; PULMONARY ARTERY; SARCOMA; TRANSMISSION ELECTRON MICROSCOPY; VASCULAR TUMOR;

ADULT; ANTIGENS, CD44; BIOMARKERS, TUMOR; CORE BINDING FACTOR ALPHA 2 SUBUNIT; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MICROSCOPY, ELECTRON, TRANSMISSION; NEOPLASMS, VASCULAR TISSUE; PULMONARY ARTERY; SARCOMA; STEM CELLS; TUNICA INTIMA;

EID: 84871927681     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2012.04241.x     Document Type: Article

References (25)

1. Bode-Lesniewska B, Zhao J, Speel EJM et al. Gains of 12q13-14 and overexpression of mdm2 are frequent findings in intimal sarcomas of the pulmonary artery. Virchows Arch. 2001; 438; 57-65.
2. Gaumann A, Petrow P, Mentzel T et al. Osteopontin expression in primary sarcomas of the pulmonary artery. Virchows Arch. 2001; 439; 668-674.
3. Ozbek C, Emrecan B, Calli AO, Gurbuz A. Intimal sarcoma of the pulmonary artery. Tex. Heart Inst. J. 2007; 34; 119-121.
4. Nakajima J, Morota T, Matsumoto J et al. Pulmonary intimal sarcoma treated by a left pneumonectomy with pulmonary arterioplasty under cardiopulmonary bypass: report of a case. Surg. Today 2007; 37; 469-499.
5. Ramos SG, Salvatti LGC, Cipriano FG, Roriz-Filho JS, Matos FD, Rossi MA. Pulmonary artery sarcoma and chronic thromboembolism. Pathol. Res. Pract. 2008; 204; 139-141.
6. Gaumann A, Bode-Lesniewska B, Zimmermann DR et al. Exploration of the APC/β-catenin (WNT) pathway and a histologic classification system for pulmonary artery intimal sarcoma A study of 18 cases. Virchows Arch. 2008; 453; 473-484.
7. Long HQ, Qin Q, Xie CH. Response of pulmonary artery intimal sarcoma to surgery, radiotherapy and chemotherapy: a case report. J. Med. Case Rep. 2008; 2; 217-219.
8. Hirose T, Ishikawa N, Hamada K et al. A case of intimal sarcoma of the pulmonary artery treated with chemoradiotherapy. Intern. Med. 2009; 48; 245-249.
9. Dornas AP, Campos FT, Rezende CJ, Ribeiro CA, Amaral NF, Corrȩa Rde A. Intimal sarcoma of the pulmonary artery: a differential diagnosis of chronic pumonary thromboembolism. J. Bras. Pneumol. 2009; 35; 814-818.
10. Hou Y, Shen Z, Gao W, Ye W. Pulmonary artery intimal sarcoma: case report. J. Card. Surg. 2010; 25; 29-31.
11. Koch A, Mechtersheimer G, Tochtermann U, Karck M. Ruptured pseudoaneurysms of the pulmonary artery - rare manifestation of a primary pulmonary artery sarcoma. Interact. Cardiovasc. Thorac. Surg. 2010; 10; 120-121.
12. Halank M, Jakob C, Kolditz M et al. Intimal pulmonary artery sarcoma presenting as severe dyspnea and right heart insufficiency. Onkologie 2010; 33; 313-316.
13. McGlennen RC, Manivel JC, Stanley SJ, Slater DL, Wick MR, Dehner LP. Pulmonary artery trunk sarcoma: a clinicopathologic, ultrastructural, and immunohistochemical study of four cases. Mod. Pathol. 1989; 2; 486-494.
14. Wagner N, Panelos J, Massi D, Wagne KD. The Wilms' tumor suppressor WT1 is associated with melanoma proliferation. Pflugers Arch. 2008; 455; 839-847.
15. Hohenstein P, Hastie ND. The many facets of the Wilms' tumour gene, WT1. Hum. Mol. Genet. 2006; 15; R196-R201.
16. Pittenger MF, Mackay AM, Beck SC et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284; 143-147.
17. Hayati AR, Fariha MN, Tan GC, Tan AE, Chua K. Potential of human decidua stem cells for angiogenesis and neurogenesis. Arch. Med. Res. 2011; 42; 291-300.
18. Swiers G, de Bruijn M, Speck NA. Hematopoietic stem cell emergence in the conceptus and the role of Runx1. Int. J. Dev. Biol. 2010; 54; 1151-1163.
19. Ghaffari S, Smadja-Joffe F, Oostendorp R et al. CD44 isoforms in normal and leukemic hematopoiesis. Exp. Haematol. 1999; 27; 978-993.
20. Klein D, Weisshardt P, Kleff V, Jastrow H, Jacob HG, Ergun S. Vascular wall-resident CD44+ multipotent stem cells give rise to pericytes and smooth muscle cells and contribute to new vessel maturation. PLoS One 2011; 6; e20540.
21. Pacilli A, Pasquinelli G. Vascular wall resident progenitor cells. A review. Exp. Cell Res. 2009; 315; 901-914.
22. Minana MD, Carbolell-Uberos F, Mirabet V, Marin S, Encabo A. Identification of hemangioblasts in the adult human adipose tissue. Stem Cells 2008; 26; 2696-2704.
23. Pasquinelli G, Pacilli A, Alviano F et al. Multidistrict human mesenchymal vascular cells: pluripotency and stemness characteristics. Cytotherapy 2010; 12; 275-287.
24. Hoshino A, Chiba H, Nagai K et al. Human vascular adventitial fibroblasts contain mesenchymal stem/progenitor cells. Biochem. Biophys. Res. Commun. 2008; 368; 305-310.
25. Sebenik M, Ricci A, DiPasquale B et al. Undifferentiated intimal sarcoma of large systemic blood vessels. Am. J. Surg. Pathol. 2005; 29; 1184-1193.