Increased brain monoaminergic tone after the NMDA receptor GluN2A subunit gene knockout is responsible for resistance to the hypnotic effect of nitrous oxide

European Journal of Pharmacology

Volumn 698, Issue 1-3, 2013, Pages 200-205

  Petrenko, Andrey B ^a   Yamakura, Tomohiro ^a   Kohno, Tatsuro ^a   Sakimura, Kenji ^b   Baba, Hiroshi ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

Author keywords

Inhalational anesthetic; Knockout mouse; Monoaminergic system; N methyl d aspartate receptor GluN2A subunit; Nitrous oxide; Secondary effect

Indexed keywords

GLUN2A PROTEIN; ISOFLURANE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NITROUS OXIDE; SEVOFLURANE; UNCLASSIFIED DRUG;

ANESTHESIA MECHANISM; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG SENSITIVITY; KNOCKOUT MOUSE; MALE; MONOAMINERGIC SYSTEM; MOUSE; NEUROPHARMACOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; UNCONSCIOUSNESS;

ANESTHETICS; ANIMALS; BIOGENIC MONOAMINES; BRAIN; DROPERIDOL; DRUG RESISTANCE; GENE KNOCKOUT TECHNIQUES; HALOGENATION; HYPNOTICS AND SEDATIVES; KETANSERIN; MALE; MICE; MICE, INBRED C57BL; NITROUS OXIDE; RECEPTORS, N-METHYL-D-ASPARTATE; REFLEX, RIGHTING; UNCONSCIOUSNESS;

EID: 84871926606     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.10.034     Document Type: Article

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