Exploring Dissociation and Oxytocin as Pathways Between Trauma Exposure and Trauma-Related Hyperemesis Gravidarum: A Test-of-Concept Pilot

Journal of Trauma and Dissociation

Volumn 14, Issue 1, 2013, Pages 40-55

  Seng, Julia ^a   Miller, Janis ^a   Sperlich, Mickey ^b   van de Ven, Cosmas J M ^a   Brown, Stephanie ^c   Carter, C Sue ^d   Liberzon, Israel ^e  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c STONY BROOK UNIVERSITY   (United States)

^d UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^e UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

dissociative disorder; hyperemesis gravidarum; oxytocin; posttraumatic stress

Indexed keywords

OXYTOCIN;

ARTICLE; CHILD ABUSE; CLINICAL ARTICLE; CONTROLLED STUDY; CONVERSION DISORDER; DISSOCIATIVE DISORDER; FEMALE; HELP SEEKING BEHAVIOR; HUMAN; HUMAN TISSUE; HYPEREMESIS GRAVIDARUM; INTESTINE MOTILITY; INTESTINE MUSCLE; NAUSEA; OXYTOCIN BLOOD LEVEL; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; VOMITING;

ADULT; ANALYSIS OF VARIANCE; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; COMORBIDITY; DISSOCIATIVE DISORDERS; FEMALE; HUMANS; HYPEREMESIS GRAVIDARUM; INTERVIEW, PSYCHOLOGICAL; LIFE CHANGE EVENTS; LINEAR MODELS; OXYTOCIN; PILOT PROJECTS; PREGNANCY; PREGNANCY COMPLICATIONS; SEVERITY OF ILLNESS INDEX; STRESS DISORDERS, POST-TRAUMATIC;

EID: 84871900783     PISSN: 15299732     EISSN: 15299740     Source Type: Journal    
DOI: 10.1080/15299732.2012.694594     Document Type: Article

References (30)

1. Alfven, G. 2004. Plasma oxytocin in children with recurrent abdominal pain. Journal of Pediatric Gastroenterology & Nutrition, 38: 513-517.
2. American Psychiatric Association. 1994. Diagnostic and statistical manual of mental disorders, 4th, Washington, DC: Author.
3. Brown, S. L. and Brown, R. M. 2006. Selective investment theory: Recasting the functional significance of close relationships. Psychological Inquiry, 17: 1-29.
4. Buckwalter, J. G. and Simpson, S. W. 2002. Psychological factors in the etiology and treatment of severe nausea and vomiting in pregnancy. American Journal of Obstetrics & Gynecology, 186: S210-S214.
5. Cyranowski, J. M., Hofkens, T. L., Frank, E., Seltman, H., Hoe-Ming, C. and Amico, J. A. 2008. Evidence of dysregulated peripheral oxytocin release among depressed women. Psychosomatic Medicine, 70: 967-975.
6. Gazmararian, J. A., Petersen, R., Jamieson, D. J., Schild, L., Adams, M. M., Deshpande, A. D. and Franks, A. L. 2002. Hospitalizations during pregnancy among managed care enrollees. Obstetrics & Gynecology, 100: 94-100.
7. Heim, C., Young, L. J., Newport, D. J., Mletzko, T., Miller, A. H. and Nemeroff, C. B. 2009. Lower CSF oxytocin concentrations in women with a history of childhood abuse. Molecular Psychiatry, 14: 954-958.
8. Hurlemann, R., Patin, A., Onur, O. A., Cohen, M. X., Baumgartner, T., Metzler, S.and Kendrick, K. M. 2010. Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans. Journal of Neuroscience, 30: 4999-5007.
9. Kilpatrick, D. G., Resnick, H. S., Freedy, J. R., Pelcovitz, D., Resick, P., Roth, S. and van der Kolk, B. 1994. "Posttraumatic stress disorder field trial: Evaluation of PTSD construct criteria A through E". In DSM-IV sourcebook, Edited by: Widiger, T. A., Frances, A. J., Pincus, H. A., Ross, R., First, M. B., Davis, W. and Kline, M. Vol. 4, 803-846. Washington, DC: American Psychiatric Press.
10. Koren, G., Boskovic, R., Hard, M., Maltepe, C., Navioz, Y. and Einarson, A. 2002. Motherisk-PUQE (pregnancy-unique quantification of emesis and nausea) scoring system for nausea and vomiting of pregnancy. American Journal of Obstetrics & Gynecology, 186: S228-S231.
11. Liberzon, I. and Young, E. A. 1997. Effects of stress and glucocorticoids on CNS oxytocin receptor binding. Psychoneuroendocrinology, 22: 411-422.
12. Maes, M., Lin, A., Bonaccorso, S., Goossens, F., Van Gastel, A., Pioli, R.and Scharpé, S. 1999. Higher serum prolyl endopeptidase activity in patients with post-traumatic stress disorder. Journal of Affective Disorders, 53: 27-34.
13. Nijenhuis, E. R., van Dyck, R., ter Kuile, M. M., Mourits, M. J., Spinhoven, P. and van der Hart, O. 2003. Evidence for associations among somatoform dissociation, psychological dissociation and reported trauma in patients with chronic pelvic pain. Journal of Psychosomatic Obstetrics and Gynaecology, 24: 87-98.
14. Nyquist, H. 1928. Certain topics in telegraph transmission theory. Transactions of the American Institute of Electrical Engineers, 47: 617-644.
15. Olff, M., Langeland, W., Witteveen, A. and Denys, D. 2010. A psychobiological rationale for oxytocin in the treatment of posttraumatic stress disorder. CNS Spectrums, 8(22): 522-530.
16. Pedersen, C., Caldwell, J., Jirikowski, G. and Insel, T. 1992. Oxytocin in maternal, sexual, and social behaviors. Annals of the New York Academy of Sciences, 652 June
17. Pitman, R. K., Orr, S. P. and Lasko, N. B. 1993. Effects of intranasal vasopression and oxytocin on physiologic responding during personal combat imagery in Vietnam veterans with posttraumatic stress disorder. Psychiatry Research, 48: 107-117.
18. Porges, S. W. 2011. The polyvagal theory, New York, NY: Norton.
19. Schore, A. N. 2003. Affect dysregulation and disorders of the self, New York, NY: Norton.
20. Seng, J. S. 2010. Is posttraumatic oxytocin dysregulation a link among posttraumatic self disorders, posttraumatic stress disorder, and pelvic visceral dysregulation conditions in women?. Journal of Trauma & Dissociation, 11: 387-406.
21. Seng, J. S., Clark, M. K., McCarthy, A. M. and Ronis, D. L. 2006. PTSD and physical co-morbidity among women: Results from service use data. Journal of Traumatic Stress, 19: 45-56.
22. Seng, J. S., Oakley, D. J., Sampselle, C. M., Killion, C., Graham-Bermann, S. and Liberzon, I. 2001. Association of posttraumatic stress disorder with pregnancy complications. Obstetrics & Gynecology, 97: 17-22.
23. Seng, J. S., Schrot, J., van de Ven, C. J. M. and Liberzon, I. 2007. Service use data analysis of pre-pregnancy psychiatric and somatic diagnoses in women with hyperemesis gravidarum. Journal of Psychosomatic Obstetrics and Gynaecology, 28: 209-217.
24. Taylor, S. E., Gonzaga, G. C., Klein, L. C., Hu, P., Greendale, G. A. and Seeman, T. E. 2006. Relation of oxytocin to psychological stress responses and hypothalamic-pituitary-adrenocortisol axis activity in older women. Psychosomatic Medicine, 68: 238-245.
25. Teicher, M. H., Anderson, S. L., Polcari, A., Anderson, C. M. and Navalta, C. P. 2002. Developmental neurobiology of childhood stress and trauma. Psychiatric Clinics of North America, 25: 397-426.
26. Uvnäs Moberg, K. 2003. The oxytocin factor: Tapping the hormone of calm, love, and healing, Cambridge, MA: Da Capo Press.
27. Waller, N. G., Carlson, E. B. and Putnam, F. W. 1996. Types of dissociation and dissociative types: A taxometric analysis of dissociative experiences. Psychological Methods, 1: 300-321.
28. Walsh, J. W., Hasler, W. L., Nugent, C. E. and Owyang, C. 1996. Progesterone and estrogen are potential mediators of gastric slow-wave dysrhythmias in nausea of pregnancy. American Journal of Physiology, 270: G506-G514.
29. Wolfe, J. and Kimerling, R. 1997. "Gender issues in the assessment of posttraumatic stress disorder". In Assessing psychological trauma and PTSD, Edited by: Wilson, J. P. and Keane, T. M. 192-238. New York, NY: Guilford Press.
30. World Health Organization. 2007. The ICD-10 classification of mental and behavioral disorders, Geneva, Switzerland: Author.