Drug reaction with eosinophilia and systemic symptoms (DRESS): A complex interaction of drugs, viruses and the immune system

Israel Medical Association Journal

Volumn 14, Issue 9, 2012, Pages 577-582

  Criado, Paulo R ^a   Avancini, João ^a   Santi, Claudia G ^a   Amoedo Medrado, Ana T ^b   Rodrigues, Carlos E ^c   de Carvalho, Jozélio F ^d  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Instituto de Medicina Especializada (IMME)   (Brazil)

^c UNIVERSITY OF FORTALEZA   (Brazil)

^d FEDERAL UNIVERSITY OF BAHIA   (Brazil)

Author keywords

Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome); Drug induced hypersensitivity syndrome (DIHS); Exanthema; Hepatitis; Herpes virus; Nephritis

Indexed keywords

ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ANTIINFECTIVE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CYTOCHROME P450; CYTOKINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EMOLLIENT AGENT; EPOXIDE HYDROLASE; GANCICLOVIR; GLUCOCORTICOID; GLUTATHIONE TRANSFERASE; HISTAMINE H1 RECEPTOR ANTAGONIST; IMMUNOGLOBULIN; METHYLPREDNISOLONE; PREDNISONE; SULFONAMIDE; SULFONE;

CLINICAL FEATURE; DISEASE SEVERITY; DRESS SYNDROME; HUMAN; MORTALITY; PLASMAPHERESIS; POLYMERASE CHAIN REACTION; REVIEW; CHEMICALLY INDUCED DISORDER; DRUG HYPERSENSITIVITY; EOSINOPHILIA; HERPES VIRUS; IMMUNOLOGY; RISK FACTOR; SYNDROME; VIROLOGY;

DRUG HYPERSENSITIVITY; EOSINOPHILIA; HERPESVIRIDAE; HUMANS; RISK FACTORS; SYNDROME;

EID: 84871887796     PISSN: 15651088     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (34)

1. Piñana E, Lei SH, Merino R, et al. DRESS-syndrome on sulfasalazine and naproxen treatment for juvenile idiopathic arthritis and reactivation of human herpevirus 6 in an 11-year-old Caucasian boy. J Clin Pharm Ther 2010; 35 (3): 365-70.
2. Shear NH, Spielberg SP. Anticonvulsant hypersensitivity syndrome. In vitro assesment of risk. J Clin Invest 1988; 82: 1826-32.
3. Fiszenson-Albala F, Auzerie V, Mahe E, et al. A 6-month prospective survey of cutaneous drug reactions in a hospital setting. Br J Dermatol 2003; 149: 1018-22.
4. Bohan KH, Mansuri TF, Wilson NM. Anticonvulsant hypersensitivity syndrome: implications for pharmaceutical care. Pharmacotherapy 2007; 2710: 1425-39.
5. Ganeva M, Gancheva T, Lazarova R, et al. Carbamazepine-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: report of four cases and brief review. Int J Dermatol 2008; 478: 853-60.
6. Sullivan JR, Shear NH. The drug hypersensitivity syndrome: what is the pathogenesis? Arch Dermatol 2001; 137: 357-64.
7. Shiohara T, Kano Y. A complex interaction between drug allergy and viral infection. Clin Rev Allerg Immunol 2007; 33: 124-33.
8. Shiohara T, Inaoka M, Kano Y. Drug-induced hypersensitivity syndrome (DIHS): a reaction induced by a complex interplay among herpesviruses and anti-drug immune responses. Allergol Int 2006; 55: 1-8.
9. Picard D, Janela B, Descamps V, et al. Drug reaction with eosinophilia and systemic symptoms (DRESS): a multiorgan antiviral T cell response. Sci Transl Med 2010; 246: 46-62.
10. Oskay T, Karademir A, Ertürk OI. Association of anticonvulsant hypersensitivity syndrome with Herpesvirus 6, 7. Epilepsy Res 2006; 701: 27-40.
11. Seishima M, Yamanaka S, Fujisawa T, Tohyama M, Hashimoto K. Reactivation of human herpesvirus (HHV) family members other than HHV-6 in drug-induced hypersensitivity syndrome. Br J Dermatol 2006; 1552: 344-9.
12. Kano Y, Hiraharas K, Sakuma K, Shiohara T. Several herpesviruses can reactivate in a severe drug-induced multiorgan reaction in the same sequential order as in graft- versus-host disease. Br J Dermatol 2006; 1552: 301-6.
13. Naisbitt DJ, Farrell J, Wong G, et al. Characterization of drug-specific T-cells in lamotrigine hypersensitivity. J Allergy Clin Immunol 2003; 111: 1393-403.
14. Wu Y, Sanderson JP, Farrel J, et al. Activation of T cells by carbamazepine and carbamazepine metabolites. J Allergy Clin Immunol 2006; 118: 233-41.
15. Kano Y, Inaoka M, Shiohara T. Association between anticonvulsant hypersensitivity syndrome and human herpesvirus 6 reactivation and hypogammaglobulinemia. Arch Dermatol 2004; 140: 183-8.
16. Aihara Y, Ito SI, Kobayashi Y, Yamakawa Y, Aihara M, Yokota S. Carbamazepine- induced hypersensitivity syndrome associated with transient hypogamma- globulinaemia and reactivation of human herpesvirus 6 infection demonstrated by real-time quantitative polymerase chain reaction. Br J Dermatol 2003; 1491: 165-9.
17. Yoshikawa T, Fujita A, Yagami A, et al. Human herpesvirus 6 reactivation and inflammatory cytokine production in patients with drug-induced hypersensitivity syndrome. J Clin Virol 2006; 37(Suppl 1): S92-6.
18. Tohyama M, Hashimoto K. New aspects of drug-induced hypersensitivity syndrome. J Dermatol 2011; 383: 228-8.
19. Shiohara T, Iijima M, Ikezawa Z, Hashimoto K. The diagnosis of a DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations. Br J Dermatol 2007; 156: 1083-4.
20. Bocquet H, Bagot M, Roujeau JC. Drug-induced pseudolymphoma and drug hypersensitivity syndrome (Drug Rash With Eosinophilia and Systemic Symptoms: DRESS). Semin Cutan Med Surg 1996; 1: 250-7.
21. Fernando SL, Henderson CJ, O'Connor KS. Drug-induced hypesensitivity syndrome with superficial granulomatous dermatites - a novel finding. Am J Dermatopathol 2009; 31: 611-13.
22. Gentile I, Talamo M, Borgia G. Is the drug-induced hypersensitivity syndrome (DIHS) due to herpesvirus 6 infection or to allergy-mediated viral reactivation? Report of a case and literature review. BMC Infect Dis 2010; 10: 49. Available on http://www.biomedcentral.com/1471-2334/10/49.
23. Criado PR, Lucena SK, Crivellaro APGS, et al. Drug hypersensitivity syndrome to anticonvulsants: report of two cases. Rev Bras Clin Terap 2002; 28: 59-63.
24. Aires NB, Criado PR, Vilela MAC, et al. Drug hypersensitivity syndrome to anticonvulsants: report of three cases. Diagn Tratamento 2006; 112: 86-90.
25. Criado PR, Criado RF, Vasconcellos C, Pegas JR, Cera PC. Drug-induced hypersensitivity syndrome due to anticonvulsants in a two-year-old boy. J Dermatol 2004; 3112: 1009-13.
26. Vittorio CC, Muglia JJ. Anticonvulsant hypersensitivity syndrome. Arch Intern Med 1995; 155: 2285-90.
27. Chang DKM, Shear NH. Cutaneous reactions to anticonvulsants. Semin Neurol 1992; 12: 329-37.
28. Eshki M, Allanore L, Musette P, et al. Twelve year analysis of severe cases of drug reaction with eosinophilia and systemic symptoms. Arch Dermatol 2009; 145: 67-72.
29. Kano Y, Ishida T, Hirahara K, Shiohara T. Visceral involvements and long-term sequelae in drug-induced hypersensitivity syndrome. Med Clin North Am 2010; 94: 743-59.
30. Kennebeck GA. Anticonvulsant hypersensitivity syndrome. J Am Board Fam Pract 2000; 13: 364-70.
31. Fittje M. Anticonvulsant hypersensitivity syndrome. Internet J Neurol 2001; 1 (1). Doi: 10.5580/2458
32. Kosseifi SG, Guha B, Nassour DN, Chi DS, Krishnaswamy G. The dapsone hypersensitivity syndrome revisited: a potentially fatal multisystem disorder with prominent hepatopulmonary manifestations. J Occup Med Toxicol 2006; 1: 9.
33. Kito Y, Ito T, Tokura Y, Hashizume H. High-dose intravenous immunoglobulin monotherapy for drug-induced hypenssensitivity syndrome. Acta Derm Venereol 2012; 92 (1): 100-1.
34. Descamps V, Ben-Saïd B, Sassolas B, et al. Management of drug reaction with eosinophilia and systemic symptoms (DRESS). Ann Dermatol Venereol 2010; 13711: 703-8.