Fundamental study of enantioselective HPLC separation of tapentadol enantiomers using cellulose-based chiral stationary phase in normal phase mode

Journal of Pharmaceutical and Biomedical Analysis

Volumn 74, Issue , 2013, Pages 111-116

  Douša, Michal ^a   Lehnert, Petr ^a,c   Adamusová, Hana ^b   Bosáková, Zuzana ^b  

^a Zentiva Prague   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c PALACKÝ UNIVERSITY   (Czech Republic)

Author keywords

Chiral HPLC separation; Chiralpak AD H; Mobile phase optimization; Tapentadol; Validation

Indexed keywords

2 PROPANOL; ALKANE DERIVATIVE; CELLULOSE; DIETHYLAMINE; DRUG ADDITIVE; HEPTANE; ORGANIC COMPOUND; TAPENTADOL; WATER;

ACCURACY; ARTICLE; CHEMICAL COMPOSITION; CHIRALITY; CONTROLLED STUDY; DRUG DETERMINATION; DRUG FORMULATION; DRUG MIXTURE; DRUG SOLUBILITY; ENANTIOMER; ENANTIOSELECTIVITY; FIELD EMISSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF DETECTION; LIMIT OF QUANTITATION; PHASE TRANSITION; PRACTICE GUIDELINE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SPECTRAL SENSITIVITY; VALIDATION PROCESS; WATER CONTENT;

CELLULOSE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; PHENOLS; STEREOISOMERISM;

EID: 84871856601     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2012.10.017     Document Type: Article

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