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Volumn 9, Issue 3, 2012, Pages 260-265

Diuretic dosing in acute decompensated heart failure: Lessons from DOSE

Author keywords

Continuous infusion; Diuretic; DOSE trial; Heart failure; Serum creatinine

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; LOOP DIURETIC AGENT; PLACEBO; CREATININE; FUROSEMIDE;

EID: 84871855495     PISSN: 15469530     EISSN: 15469549     Source Type: Journal    
DOI: 10.1007/s11897-012-0094-8     Document Type: Article
Times cited : (9)

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    • Allen LA, Turer AT, DeWald T et al. Continuous versus Bolus Dosing of Furosemide for Patients Hospitalized for Heart Failure. Am J Cardiol 2010;105:1794-1797. This paper presents the data from a prospective, open-label, single-center, randomized trial evaluating bolus injection versus continuous infusion of furosemide in acute decompensated heart failure. The study enrolled 41 patients with a mean EF of 35%. The authors found no difference in regards to change in serum creatinine, urine output, electrolyte abnormalities, or length of stay between the two treatment strategies. The authors concluded that continuous infusion and bolus dosing of furosemide were of equal effectiveness and safety in acute decompensated heart failure.
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    • Continuous versus intermittent infusion of furosemide in acute decompensated heart failure
    • This small (56 patient), prospective, randomized parallel study evaluated the effectiveness of continuous and intermittent infusion of intravenous diuretics. Patients receiving continuous infusion furosemide experienced significantly greater diuresis compared to intermittent infusion (3726±1121 mL/24 h vs 2955±1267 mL/24 h, respectively [P00.019]). The authors concluded that continuous infusion was safe and more effective than intermittent infusion
    • Thompson MR, Nappi JM, Dunn SP et al. Continuous versus Intermittent Infusion of Furosemide in Acute Decompensated Heart Failure. J Cardiac Fail. 2010;16:188-193. This small (56 patient), prospective, randomized parallel study evaluated the effectiveness of continuous and intermittent infusion of intravenous diuretics. Patients receiving continuous infusion furosemide experienced significantly greater diuresis compared to intermittent infusion (3726±1121 mL/24 h vs 2955±1267 mL/24 h, respectively [P00.019]). The authors concluded that continuous infusion was safe and more effective than intermittent infusion.
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