Therapy failure resulting from superinfection by a drug-resistant HIV variant

Antiviral Therapy

Volumn 17, Issue 8, 2012, Pages 1621-1625

  Pingen, Marieke ^a,b   Nouwen, Jan L ^a   Dinant, Sander ^a   Albert, Jan ^c,d   Mild, Mattias ^c   Brodin, Johanna ^c   Simen, Birgitte B ^e   Walsh, Susan ^a   Kayser, Manfred ^a   Van Der Ende, Marchina E ^a   Schutten, Martin ^a   Boucher, Charles A B ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c KAROLINSKA INSTITUTE   (Sweden)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^e A Roche Company   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EFAVIRENZ; LAMIVUDINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; TENOFOVIR; VIRUS RNA;

ARTICLE; CASE REPORT; ENVELOPE GENE; GENE MUTATION; GENE SEQUENCE; HIGH RISK POPULATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NUCLEOTIDE SEQUENCE; PHYLOGENY; PRIORITY JOURNAL; PYROSEQUENCING; STRUCTURAL GENE; SUPERINFECTION; TREATMENT FAILURE; VIRUS STRAIN; WILD TYPE;

ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; DRUG RESISTANCE, VIRAL; GENES, ENV; GENES, POL; GENOTYPE; HIV INFECTIONS; HIV-1; HUMANS; MUTATION; PHYLOGENY; SUPERINFECTION; TREATMENT FAILURE; VIRAL LOAD;

EID: 84871854765     PISSN: 13596535     EISSN: 20402058     Source Type: Journal    
DOI: 10.3851/IMP2267     Document Type: Article

References (14)

1. Smith DM, Richman DD, Little SJ. HIV superinfection. J Infect Dis 2005; 192:438-444. (Pubitemid 41023122)
2. Smith DM, Wong JK, Hightower GK, et al. Incidence of HIV superinfection following primary infection. JAMA 2004; 292:1177-1178. (Pubitemid 39167405)
3. Rachinger A, Manyenga P, Burger JA, et al. Low incidence of HIV-1 superinfection even after episodes of unsafe sexual behavior of homosexual men in the Amsterdam Cohort Studies on HIV Infection and AIDS. J Infect Dis 2011; 203:1621-1628.
4. Koelsch KK, Smith DM, Little SJ, et al. Clade B HIV-1 superinfection with wild-type virus after primary infection with drug-resistant clade B virus. AIDS 2003; 17:F11-F16. (Pubitemid 36549704)
5. Yang OO, Daar ES, Jamieson BD, et al. Human immunodeficiency virus type 1 clade B superinfection: evidence for differential immune containment of distinct clade B strains. J Virol 2005; 79:860-868. (Pubitemid 40053869)
6. Brenner B, Routy JP, Quan Y, et al. Persistence of multidrug-resistant HIV-1 in primary infection leading to superinfection. AIDS 2004; 18:1653-1660. (Pubitemid 39095782)
7. Smith DM, Wong JK, Hightower GK, et al. HIV drug resistance acquired through superinfection. AIDS 2005; 19:1251-1256. (Pubitemid 41224893)
8. Simen BB, Simons JF, Hullsiek KH, et al. Low-abundance drug-resistant viral variants in chronically HIV-infected, antiretroviral treatment-naive patients significantly impact treatment outcomes. J Infect Dis 2009; 199:693-701.
9. Le T, Chiarella J, Simen BB, et al. Low-abundance HIV drug-resistant viral variants in treatment-experienced persons correlate with historical antiretroviral use. PLoS ONE 2009; 4:e6079.
10. Mild M, Hedskog C, Jernberg J, Albert J. Performance of ultra-deep pyrosequencing in analysis of HIV-1 pol gene variation. PLoS ONE 2011; 6:e22741.
11. Leitner T, Korovina G, Marquina S, Smolskaya T, Albert J. Molecular epidemiology and MT-2 cell tropism of Russian HIV type 1 variant. AIDS Res Hum Retroviruses 1996; 12:1595-1603. (Pubitemid 26423240)
12. Bacheler L, Jeffrey S, Hanna G, et al. Genotypic correlates of phenotypic resistance to efavirenz in virus isolates from patients failing nonnucleoside reverse transcriptase inhibitor therapy. J Virol 2001; 75:4999-5008. (Pubitemid 32448520)
13. Yang OO, Sarkis PT, Ali A, et al. Determinant of HIV-1 mutational escape from cytotoxic T lymphocytes. J Exp Med 2003; 197:1365-1375. (Pubitemid 36617783)
14. van der Kuyl AC, Kozaczynska K, Arien KK, et al. Analysis of infectious virus clones from two HIV-1 superinfection cases suggests that the primary strains have lower fitness. Retrovirology 2010; 7:60.