Toxicodynamics of rigid polystyrene microparticles on pulmonary gas exchange in mice: Implications for microemboli-based drug delivery systems

Toxicology and Applied Pharmacology

Volumn 266, Issue 2, 2013, Pages 214-223

  Kutscher, H L ^a   Gao, D ^a,b   Li, S ^a,b   Massa, C B ^a   Cervelli, J ^a   Deshmukh, M ^a,b   Joseph, L B ^a,b   Laskin, D L ^a,b   Sinko, P J ^a,b  

^a RUTGERS UNIVERSITY   (United States)

^b Environmental and Occupational Health Sciences Institute   (United States)

Author keywords

Passive pulmonary targeting; Pulmonary gas exchange; Rigid microparticle; Shunt; Ventilation perfusion ratio

Indexed keywords

POLYSTYRENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD; CIRCULATION; DRUG DELIVERY SYSTEM; LUNG GAS EXCHANGE; LUNG VENTILATION PERFUSION RATIO; MALE; MEMBRANE MICROPARTICLE; MICROEMBOLISM; MOUSE; NONHUMAN; OXYGEN AFFINITY; OXYGEN CONCENTRATION; OXYGEN SATURATION; PARTICLE SIZE; PULSE OXIMETER;

ANIMALS; DRUG DELIVERY SYSTEMS; FEASIBILITY STUDIES; LUNG; MALE; MICE; MICROSPHERES; MODELS, THEORETICAL; NONLINEAR DYNAMICS; OXIMETRY; OXYGEN; PARTICLE SIZE; POLYSTYRENES; PULMONARY EMBOLISM; PULMONARY GAS EXCHANGE;

MUS;

EID: 84871847234     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.10.021     Document Type: Article

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