Quantification in molecular ultrasound imaging a comparative study in mice between healthy liver and a human hepatocellular carcinoma xenograft

Journal of Ultrasound in Medicine

Volumn 31, Issue 12, 2012, Pages 1909-1916

  Sugimoto, Katsutoshi ^a   Moriyasu, Fuminori ^a   Negishi, Yoichi ^b   Hamano, Nobuhito ^b   Oshiro, Hisashi ^a   Rognin, Nicolas G ^c   Yoshida, Tetsuya ^d   Kamiyama, Naohisa ^d   Aramaki, Yukihiko ^b   Imai, Yasuharu ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^c Toshiba Medical Research Institute USA Inc   (United States)

^d TOSHIBA MEDICAL SYSTEMS CORPORATION   (Japan)

Author keywords

Angiogenesis; BR55; Hepatocellular carcinoma; Molecular ultrasound; Vascular endothelial growth factor receptor 2

Indexed keywords

BINS; BIOLOGICAL MATERIALS; CURVE FITTING; ENDOTHELIAL CELLS; FUNCTIONS; GROWTH KINETICS; MAMMALS; MICROCIRCULATION; TUMORS; ULTRASONIC IMAGING;

ANGIOGENESIS; BR55; CONTRAST ENHANCEMENT; HEPATOCELLULAR CARCINOMA; TARGETED MICROBUBBLES; TIME-INTENSITY CURVES; VASCULAR ENDOTHELIAL CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR;

MOLECULAR IMAGING;

DIAGNOSTIC AGENT; VASCULOTROPIN RECEPTOR 2;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; COMPARATIVE STUDY; ECHOGRAPHY; HUMAN; LIVER; LIVER CELL CARCINOMA; LIVER TUMOR; METHODOLOGY; MICROBUBBLE; MOLECULAR DIAGNOSIS; MOUSE; TUMOR CELL LINE;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; HUMANS; LIVER; LIVER NEOPLASMS; MICE; MICE, INBRED BALB C; MICROBUBBLES; MOLECULAR DIAGNOSTIC TECHNIQUES; NEOPLASM TRANSPLANTATION; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84871821612     PISSN: 02784297     EISSN: 15509613     Source Type: Journal    
DOI: 10.7863/jum.2012.31.12.1909     Document Type: Article

References (29)

1. Moriyasu F, Itoh K. Efficacy of perflubutane microbubble-enhanced ultrasound in the characterization and detection of focal liver lesions: phase 3 multicenter clinical trial. AJR Am J Roentgenol 2009; 193:86-95.
2. Wilson SR, Burns PN. Microbubble-enhanced US in body imaging: what role? Radiology 2010; 257:24-39.
3. Quaia E. The real capabilities of contrast-enhanced ultrasound in the characterization of solid focal liver lesions. Eur Radiol 2011; 21:457-462.
4. Lassau N, Koscielny S, Chami L, et al. Advanced hepatocellular carcinoma: early evaluation of response to bevacizumab therapy at dynamic contrast-enhanced US with quantification - preliminary results. Radiology 2011; 258:291-300.
5. Willmann JK, Paulmurugan R, Chen K, et al. US imaging of tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice. Radiology 2008; 246:508-518.
6. Pysz MA, Foygel K, Rosenberg J, Gambhir SS, Schneider M, Willmann JK. Antiangiogenic cancer therapy: monitoring with molecular US and a clinically translatable contrast agent (BR55). Radiology 2010; 256:519-527.
7. Tardy I, Pochon S, Theraulaz M, et al. Ultrasound molecular imaging of VEGFR2 in a rat prostate tumor model using BR55. Invest Radiol 2010; 45:573-578.
8. Pochon S, Tardy I, Bussat P, et al. BR55: a lipopeptide-based VEGFR2- targeted ultrasound contrast agent for molecular imaging of angiogenesis. Invest Radiol 2010; 45:89-95.
9. Shibuya M. Differential roles of vascular endothelial growth factor receptor- 1 and receptor-2 in angiogenesis. J Biochem Mol Biol 2006; 39:469- 478. (Pubitemid 44714526)
10. Carmeliet P. Angiogenesis in life, disease and medicine. Nature 2005; 438:932-936. (Pubitemid 43093958)
11. Shrivastava A, von Wronski MA, Sato AK, et al. A distinct strategy to generate high-affinity peptide binders to receptor tyrosine kinases. Protein Eng Des Sel 2005; 18:417-424. (Pubitemid 41219888)
12. Pillai R, Marinelli ER, Swenson RE. A Flexible method for preparation of peptide homo- and heterodimers functionalized with affinity probes, chelating ligands, and latent conjugating groups. Biopolymers (Peptide Sci) 2006; 84:576-585. (Pubitemid 44935257)
13. Pillai R, Marinelli ER, Fan H. A phospholipid-PEG2000 conjugated of a vascular endothelial growth factor receptor 2 (VEGFR2)-targeting heterodimer peptide for contrast-enhanced ultrasound imaging of angiogenesis. Bioconjug Chem 2010; 21:556-562.
14. Burns PN. Harmonic imaging with ultrasound contrast agents. Clin Radiol 1996; 51(suppl 1):50-55. (Pubitemid 26068989)
15. Schneider M, Arditi M, Barrau MB, et al. BR1: a new ultrasonographic contrast agent based on sulfur hexafluoride-filled microbubbles. Invest Radiol 1995; 30:451-457.
16. Arditi M, Frinking PJ, Zhou X, Rognin NG. A new formalism for the quantification of tissue perfusion by the destruction-replenishment method in contrast ultrasound imaging. IEEE Trans Ultrason Ferroelectr Freq Control 2006; 53:1118-1129. (Pubitemid 46405092)
17. Bogaard JM, Jansen JR, von Reth EA, Versprille A, Wise ME. Random walk type models for indicator-dilution studies: comparison of a local density random walk and a first passage times distribution.cardiovasc Res 1986; 20:789-796. (Pubitemid 17185832)
18. Davenport R. The derivation of the gamma-variate relationship for tracer dilution curves. J Nucl Med 1983; 24:945-948. (Pubitemid 14236778)
19. Sheppard CW. Mathematical considerations of indicator dilution techniques. Minn Med 1954; 37:93-104.
20. Mischi M. Contrast Echocardiography for Cardiac Quantifications [PhD dissertation]. Eindhoven, the Netherlands: Technische Universteit Eindhoven; 2004:84-85.
21. Shimizu H, Miyazaki M, Wakabayashi Y, et al. Vascular endothelial growth factor secreted by replicating hepatocytes induces sinusoidal endothelial cell proliferation during regeneration after partial hepatectomy in rats. J Hepatol 2001; 34:683-689. (Pubitemid 32488783)
22. Walday P, Tolleshaug H, Gjøen T, et al. Biodistributions of air-filled albumin microspheres in rats and pigs. Biochem J 1994; 299:437-443. (Pubitemid 24114137)
23. Willmann JK, Cheng Z, Davis C, et al. Targeted microbubbles for imaging tumor angiogenesis: assessment of whole-body biodistribution with dynamic micro-PET in mice. Radiology 2008; 249:212-219.
24. Zeng W, Gouw AS, van den Heuvel MC, et al. The angiogenic makeup of human hepatocellular carcinoma does not favor vascular endothelial growth factor/angiopoietin-driven sprouting neovascularization. Hepatology 2008; 48:1517-1527.
25. Yamaguchi R, Yano H, Nakashima Y, et al. Expression and localization of vascular endothelial growth factor receptors in human hepatocellular carcinoma and non-HCC tissues. Oncol Rep 2000; 7:725-729.
26. Huang J, Zhang X, Tang Q, et al. Prognostic significance and potential therapeutic target of VEGFR2 in hepatocellular carcinoma. J Clin Pathol 2011; 64:343-348.
27. Bzyl J, Lederle W, Rix A, et al. Molecular and functional ultrasound imaging in differently aggressive breast cancer xenografts using two novel ultrasound contrast agents (BR55 and BR38). Eur Radiol2011; 21:1988-1995.
28. Aucejo F, Kim R, Zein N, et al. Vascular endothelial growth factor receptor 2 expression in non-tumorous cirrhotic liver is higher when hepatoma is beyond Milan criteria. Liver Transpl 2009; 15:169-176.
29. Sarkar K, Katiyar A, Jain P. Growth and dissolution of an encapsulated contrast microbubble: effects of encapsulation permeability. Ultrasound Med Biol 2009; 35:1385-1396.