메뉴 건너뛰기




Volumn 38, Issue 1, 2013, Pages 40-47

Exendin-4 protects murine pancreatic β-cells from free fatty acid-induced apoptosis through PI-3K signaling

Author keywords

Akt Bcl 2; Apoptosis; Exendin 4; Free fatty acid; Glucagon like peptide 1; Pancreatic islets cell

Indexed keywords

EXENDIN 4; FATTY ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; WORTMANNIN; PROTEIN BAX;

EID: 84871789580     PISSN: 07435800     EISSN: 15324206     Source Type: Journal    
DOI: 10.3109/07435800.2012.713423     Document Type: Article
Times cited : (7)

References (22)
  • 1
    • 0037219411 scopus 로고    scopus 로고
    • Beta-cell deficit and increased betacell apoptosis in humans with type 2 diabetes
    • Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. Beta-cell deficit and increased betacell apoptosis in humans with type 2 diabetes. Diabetes 2003;52(1):102-110.
    • (2003) Diabetes , vol.52 , Issue.1 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.A.5    Butler, P.C.6
  • 2
    • 50549096838 scopus 로고    scopus 로고
    • Exendin-4 protected murine MIN6 pancreatic beta-cells from oxidative stress-induced apoptosis via down-regulation of NF-kappaB-iNOS-NO pathway
    • Liu LB, Wang YP, Pan XD, Jiang SY, Chen Z. Exendin-4 protected murine MIN6 pancreatic beta-cells from oxidative stress-induced apoptosis via down-regulation of NF-kappaB-iNOS-NO pathway. Yao Xue Xue Bao 2008;43(7):690-694.
    • (2008) Yao Xue Xue Bao , vol.43 , Issue.7 , pp. 690-694
    • Liu, L.B.1    Wang, Y.P.2    Pan, X.D.3    Jiang, S.Y.4    Chen, Z.5
  • 3
    • 0242584873 scopus 로고    scopus 로고
    • Increased islet apoptosis in Pdx1\+/mice
    • Johnson JD, Ahmed NT, Luciani DS, et al. Increased islet apoptosis in Pdx1\+/mice. J Clin Invest 2003;111(8):1147-1160.
    • (2003) J Clin Invest , vol.111 , Issue.8 , pp. 1147-1160
    • Johnson, J.D.1    Ahmed, N.T.2    Luciani, D.S.3
  • 5
    • 26244456414 scopus 로고    scopus 로고
    • ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity
    • Wang H, Kouri G, Wollheim CB. ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity. J Cell Sci 2005;118(Pt. 17):3905-3915.
    • (2005) J Cell Sci , vol.118 , Issue.PART 17 , pp. 3905-3915
    • Wang, H.1    Kouri, G.2    Wollheim, C.B.3
  • 6
    • 33847633375 scopus 로고    scopus 로고
    • Hepatocyte growth factor protects rat RINm5F cell line against free fatty acid-induced apoptosis by counteracting oxidative stress
    • Santangelo C, Matarrese P, Masella R, et al. Hepatocyte growth factor protects rat RINm5F cell line against free fatty acid-induced apoptosis by counteracting oxidative stress. J Mol Endocrinol 2007;38(1-2):147-158.
    • (2007) J Mol Endocrinol , vol.38 , Issue.1-2 , pp. 147-158
    • Santangelo, C.1    Matarrese, P.2    Masella, R.3
  • 7
    • 0345354674 scopus 로고    scopus 로고
    • Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function
    • Maedler K, Oberholzer J, Bucher P, Spinas GA, Donath MY. Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. Diabetes 2003;52(3):726-733.
    • (2003) Diabetes , vol.52 , Issue.3 , pp. 726-733
    • Maedler, K.1    Oberholzer, J.2    Bucher, P.3    Spinas, G.A.4    Donath, M.Y.5
  • 8
    • 33746911197 scopus 로고    scopus 로고
    • Sequential activation of caspases and synergistic beta-cell cytotoxicity by palmitate and anti-Fas antibodies
    • Hirota N, Otabe S, Nakayama H, Yuan X, Yamada K. Sequential activation of caspases and synergistic beta-cell cytotoxicity by palmitate and anti-Fas antibodies. Life Sci 2006;79(13):1312-1316.
    • (2006) Life Sci , vol.79 , Issue.13 , pp. 1312-1316
    • Hirota, N.1    Otabe, S.2    Nakayama, H.3    Yuan, X.4    Yamada, K.5
  • 9
    • 33646002042 scopus 로고    scopus 로고
    • Protein kinase B/Akt signalling is required for palmitate-induced beta-cell lipotoxicity
    • Higa M, Shimabukuro M, Shimajiri Y, Takasu N, Shinjyo T, Inaba T. Protein kinase B/Akt signalling is required for palmitate-induced beta-cell lipotoxicity. Diabetes Obes Metab 2006;8(2):228-233.
    • (2006) Diabetes Obes Metab , vol.8 , Issue.2 , pp. 228-233
    • Higa, M.1    Shimabukuro, M.2    Shimajiri, Y.3    Takasu, N.4    Shinjyo, T.5    Inaba, T.6
  • 10
    • 48949088649 scopus 로고    scopus 로고
    • Antiproliferative effect of pro-inflammatory cytokines in cultured beta cells is associated with extracellular signal-regulated kinase 1/2 pathway inhibition: Protective role of glucagon-like peptide-1
    • Blandino-Rosano M, Perez-Arana G, Mellado-Gil JM, Segundo C, Aguilar-Diosdado M. Antiproliferative effect of pro-inflammatory cytokines in cultured beta cells is associated with extracellular signal-regulated kinase 1/2 pathway inhibition: protective role of glucagon-like peptide-1. J Mol Endocrinol 2008;41(1):35-44.
    • (2008) J Mol Endocrinol , vol.41 , Issue.1 , pp. 35-44
    • Blandino-Rosano, M.1    Perez-Arana, G.2    Mellado-Gil, J.M.3    Segundo, C.4    Aguilar-Diosdado, M.5
  • 11
    • 78649489519 scopus 로고    scopus 로고
    • Exendin-4 protects murine pancreatic beta-cells from dexamethasone- induced apoptosis through PKA and PI-3K signaling
    • Wang LX, Wang YP, Chen Z, et al. Exendin-4 protects murine pancreatic beta-cells from dexamethasone-induced apoptosis through PKA and PI-3K signaling. Diabetes Res Clin Pract 2010;90 (3):297-304.
    • (2010) Diabetes Res Clin Pract , vol.90 , Issue.3 , pp. 297-304
    • Wang, L.X.1    Wang, Y.P.2    Chen, Z.3
  • 12
    • 48449104756 scopus 로고    scopus 로고
    • Exendin-4 protects beta-cells from interleukin-1 beta-induced apoptosis by interfering with the c-Jun NH2-terminal kinase pathway
    • Ferdaoussi M, Abdelli S, Yang JY, et al. Exendin-4 protects beta-cells from interleukin-1 beta-induced apoptosis by interfering with the c-Jun NH2-terminal kinase pathway. Diabetes 2008;57(5):1205-1215.
    • (2008) Diabetes , vol.57 , Issue.5 , pp. 1205-1215
    • Ferdaoussi, M.1    Abdelli, S.2    Yang, J.Y.3
  • 13
    • 77951984318 scopus 로고    scopus 로고
    • Exendin-4 protects pancreatic beta cells from the cytotoxic effect of rapamycin by inhibiting JNK and p38 phosphorylation
    • Kawasaki Y, Harashima S, Sasaki M, et al. Exendin-4 protects pancreatic beta cells from the cytotoxic effect of rapamycin by inhibiting JNK and p38 phosphorylation. Horm Metab Res 2010;42(5):311-317.
    • (2010) Horm Metab Res , vol.42 , Issue.5 , pp. 311-317
    • Kawasaki, Y.1    Harashima, S.2    Sasaki, M.3
  • 14
    • 23944479411 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 protects beta cells from cytokineinduced apoptosis and necrosis: Role of protein kinase B
    • Li L, El-Kholy W, Rhodes CJ, Brubaker PL. Glucagon-like peptide-1 protects beta cells from cytokineinduced apoptosis and necrosis: role of protein kinase B. Diabetologia 2005;48(7):1339-1349.
    • (2005) Diabetologia , vol.48 , Issue.7 , pp. 1339-1349
    • Li, L.1    El-Kholy, W.2    Rhodes, C.J.3    Brubaker, P.L.4
  • 15
    • 0037386156 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 50-adenosine monophosphate-dependent protein kinase A-and a phosphatidylinositol 3-kinase-dependent pathway
    • Hui H, Nourparvar A, Zhao X, Perfetti R. Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 50-adenosine monophosphate-dependent protein kinase A-and a phosphatidylinositol 3-kinase-dependent pathway. Endocrinology 2003;144(4):1444-1455.
    • (2003) Endocrinology , vol.144 , Issue.4 , pp. 1444-1455
    • Hui, H.1    Nourparvar, A.2    Zhao, X.3    Perfetti, R.4
  • 16
    • 19744378169 scopus 로고    scopus 로고
    • Relationship between peripheral insulin resistance and betacell function in obese subjects
    • Li HL, Yu YR, Yu HL, Wang C, Zhang XX. Relationship between peripheral insulin resistance and betacell function in obese subjects. Sichuan Da Xue Xue Bao Yi Xue Ban 2005;36(3):378-381.
    • (2005) Sichuan da Xue Xue Bao Yi Xue Ban , vol.36 , Issue.3 , pp. 378-381
    • Li, H.L.1    Yu, Y.R.2    Yu, H.L.3    Wang, C.4    Zhang, X.X.5
  • 17
    • 33646856191 scopus 로고    scopus 로고
    • Chronic effects of different non-esterified fatty acids on pancreatic islets of rats
    • Wang Y, Wang PY, Takashi K. Chronic effects of different non-esterified fatty acids on pancreatic islets of rats. Endocrine 2006;29(1):169-173.
    • (2006) Endocrine , vol.29 , Issue.1 , pp. 169-173
    • Wang, Y.1    Wang, P.Y.2    Takashi, K.3
  • 18
    • 0036828227 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats
    • Farilla L, Hui H, Bertolotto C, et al. Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats. Endocrinology 2002;143(11):4397-4408.
    • (2002) Endocrinology , vol.143 , Issue.11 , pp. 4397-4408
    • Farilla, L.1    Hui, H.2    Bertolotto, C.3
  • 20
    • 1842855402 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells
    • Wang Q, Li L, Xu E, Wong V, Rhodes C, Brubaker PL. Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells. Diabetologia 2004;47 (3):478-487.
    • (2004) Diabetologia , vol.47 , Issue.3 , pp. 478-487
    • Wang, Q.1    Li, L.2    Xu, E.3    Wong, V.4    Rhodes, C.5    Brubaker, P.L.6
  • 21
    • 43249085016 scopus 로고    scopus 로고
    • Enhanced protection against cytokine-and fatty acid-induced apoptosis in pancreatic beta cells by combined treatment with glucagon-like peptide-1 receptor agonists and insulin analogues
    • Tews D, Werner U, Eckel J. Enhanced protection against cytokine-and fatty acid-induced apoptosis in pancreatic beta cells by combined treatment with glucagon-like peptide-1 receptor agonists and insulin analogues. Horm Metab Res 2008;40(3):172-180.
    • (2008) Horm Metab Res , vol.40 , Issue.3 , pp. 172-180
    • Tews, D.1    Werner, U.2    Eckel, J.3
  • 22
    • 33745319608 scopus 로고    scopus 로고
    • Dexamethasone induces cell death in insulin-secreting cells, an effect reversed by exendin-4
    • Ranta F, Avram D, Berchtold S, et al. Dexamethasone induces cell death in insulin-secreting cells, an effect reversed by exendin-4. Diabetes 2006;55(5):1380-1390.
    • (2006) Diabetes , vol.55 , Issue.5 , pp. 1380-1390
    • Ranta, F.1    Avram, D.2    Berchtold, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.