Multiplexed volumetric bar-chart chip for point-of-care diagnostics

Nature Communications

Volumn 3, Issue , 2012, Pages

  Song, Yujun ^a   Zhang, Yuanqing ^a   Bernard, Paul E ^a   Reuben, James M ^b   Ueno, Naoto T ^b   Arlinghaus, Ralph B ^b   Zu, Youli ^c   Qin, Lidong ^a  

^a HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c HOUSTON METHODIST HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CARCINOEMBRYONIC ANTIGEN; CATALASE; CHORIONIC GONADOTROPIN; OXYGEN; PROTEIN;

BIOMARKER; ENZYME ACTIVITY; PERFORMANCE ASSESSMENT; QUANTITATIVE ANALYSIS; SAMPLING; VOLUME;

ARTICLE; BLOOD SAMPLING; DATA PROCESSING; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HOSPITAL INFORMATION SYSTEM; HUMAN; MEDICAL DEVICE; MICROFLUIDICS; TEMPERATURE; THERMODYNAMICS; V-CHIP;

BIOLOGICAL MARKERS; CATALASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; HYDROGEN PEROXIDE; MICROFLUIDIC ANALYTICAL TECHNIQUES; MICROFLUIDICS; POINT-OF-CARE SYSTEMS; REPRODUCIBILITY OF RESULTS;

EID: 84871765172     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms2292     Document Type: Article

References (36)

1. Hood, L., Heath, J. R., Phelps,M. E. & Lin, B. Y. Systems biology and new technologies enable predictive and preventative medicine. Science 306, 640-643 (2004). (Pubitemid 39440903)
2. Weston, A. D. & Hood, L. Systems biology, proteomics, and the future of health care: toward predictive, preventative, and personalized medicine. J. Proteom. Res. 3, 179-196 (2004). (Pubitemid 38500984)
3. Hood, L. & Friend, S. H. Predictive, personalized, preventive, participatory (P4) cancer medicine. Nat. Rev. Clin. Oncol. 8, 184-187 (2011).
4. Whitesides, G. M. The origins and the future of microfluidics. Nature 442, 368-373 (2006). (Pubitemid 44264779)
5. Hong, J. W. & Quake, S. R. Integrated nanoliter systems. Nat. Biotechnol. 21, 1179-1183 (2003). (Pubitemid 37186174)
6. Ismagilov, R. F. Integrated microfluidic systems. Angew. Chem. Int. Ed. 42, 4130-4132 (2003). (Pubitemid 37168927)
7. Gervais, L., de Rooij, N. & Delamarche, E. Microfluidic chips for point-of-care immunodiagnostics. Adv. Mater. 23, H151-H176 (2011).
8. Chin, C. D. et al. Microfluidics-based diagnostics of infectious diseases in the developing world. Nat. Med. 17, 1015-U1138 (2011).
9. Fan, R. et al. Integrated barcode chips for rapid, multiplexed analysis of proteins in microliter quantities of blood. Nat. Biotechnol. 26, 1373-1378 (2008).
10. Stern, E. et al. Label-free biomarker detection from whole blood. Nat. Nanotechnol. 5, 138-142 (2009).
11. Xiang, Y. & Lu, Y. Using personal glucose meters and functional DNA sensors to quantify a variety of analytical targets. Nat. Chem. 3, 697-703 (2011).
12. Addae-Mensah, K. A., Cheung, Y. K., Fekete, V., Rendely, M. S. & Sia, S. K. Actuation of elastomeric microvalves in point-of-care settings using handheld, battery-powered instrumentation. Lab Chip 10, 1618-1622 (2010).
13. Qin, L. D., Vermesh, O., Shi, Q. H. & Heath, J. R. Self-powered microfluidic chips for multiplexed protein assays from whole blood. Lab Chip 9, 2016-2020 (2009).
14. Dimov, I. K. et al. Stand-alone self-powered integrated microfluidic blood analysis system (SIMBAS). Lab Chip 11, 845-850 (2011).
15. Du, W. B., Li, L., Nichols, K. P. & Ismagilov, R. F. SlipChip. Lab Chip 9, 2286-2292 (2009).
16. Liu, W. S., Chen, D. L., Du, W. B., Nichols, K. P. & Ismagilov, R. F. Slip chip for immunoassays in nanoliter volumes. Anal. Chem. 82, 3276-3282 (2010).
17. Martinez, A. W., Phillips, S. T.,Whitesides, G. M. & Carrilho, E. Diagnostics for the developing world: microfluidic paper-based analytical devices. Anal. Chem. 82, 3-10 (2010).
18. Wang, J. et al. A self-powered, one-step chip for rapid, quantitative and multiplexed detection of proteins from pinpricks of whole blood. Lab Chip 10, 3157-3162 (2010).
19. George, P. Reaction between catalase and hydrogen peroxide. Nature 159, 41-43 (1947).
20. Nam, Y., Branch, D. W. & Wheeler, B. C. Epoxy-silane linking of biomolecules is simple and effective for patterning neuronal cultures. Biosens. Bioelectron 22, 589-597 (2006). (Pubitemid 44635194)
21. Shin, Y. et al. Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels. Nat. Protocols 7, 1247-1259 (2012).
22. Cole, L. A. New discoveries on the biology and detection of human chorionic gonadotropin. Reprod. Biol. Endocrinol. 7, 8 (2009).
23. Carpenter, A. B. Enzyme-linked immunoassays. in Manual of Clinical Laboratory Immunology. (eds Rose, N. R., de Macario, E. C., Folds, J. D., Lane, H. C. & Nakamura, R. M.) 20-29 (ASM Press, 1997).
24. Yeh, I. T. Measuring HER-2 in breast cancer. Immunohistochemistry, FISH, or ELISA? Am. J. Clin. Pathol. 117, S26-35 (2002).
25. Konecny, G. et al. Quantitative association between HER-2/neu and steroid hormone receptors in hormone receptor-positive primary breast cancer. J. Natl Cancer Inst. 95, 142-153 (2003). (Pubitemid 36193263)
26. Heppner, G. H. Tumor heterogeneity. Cancer Res. 44, 2259-2265 (1984). (Pubitemid 14110633)
27. Yurkovetsky, Z. et al. Development of a multimarker assay for early detection of ovarian cancer. J. Clin. Oncol. 28, 2159-2166 (2010).
28. Patz, Jr E. F. et al. Panel of serum biomarkers for the diagnosis of lung cancer. J. Clin. Oncol. 25, 5578-5583 (2007).
29. de Lemos, J. A. & Lloyd-Jones, D. M. Multiple biomarker panels for cardiovascular risk assessment. N. Engl. J. Med. 358, 2172-2174 (2008). (Pubitemid 351679606)
30. Neve, R. M. et al. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell 10, 515-527 (2006). (Pubitemid 44854747)
31. Duffy, M. J. Serum tumor markers in breast cancer: are they of clinical value? Clin. Chem. 52, 345-351 (2006).
32. Ebeling, F. G. et al. Serum CEA and CA 15-3 as prognostic factors in primary breast cancer. Br. J. Cancer 86, 1217-1222 (2002).
33. Meigs, J. B. Multiple biomarker prediction of type 2 diabetes. Diabetes Care 32, 1346-1348 (2009).
34. Ray, S. et al. Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins. Nat. Med. 13, 1359-1362 (2007). (Pubitemid 350073592)
35. Perco, P. et al. Protein biomarkers associated with acute renal failure and chronic kidney disease. Eur. J. Clin. Invest. 36, 753-763 (2006). (Pubitemid 44569963)
36. Gaster, R. S. et al. Matrix-insensitive protein assays push the limits of biosensors in medicine. Nat. Med. 15, 1327-1332 (2009).