Heterosexual HIV-1 infectiousness and antiretroviral use: Systematic review of prospective studies of discordant couples

Epidemiology

Volumn 24, Issue 1, 2013, Pages 110-121

  Baggaley, Rebecca F ^a   White, Richard G ^b   Hollingsworth, T Déirdre ^a   Boily, Marie Claude ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ANTIVIRAL THERAPY; CLINICAL EFFECTIVENESS; FOLLOW UP; HETEROSEXUAL FEMALE; HETEROSEXUAL MALE; HETEROSEXUALITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; INCIDENCE; META ANALYSIS; PRIORITY JOURNAL; REVIEW; SEXUAL TRANSMISSION; SOCIOECONOMICS; SYSTEMATIC REVIEW; VIRUS TRANSMISSION;

ANTI-HIV AGENTS; DEVELOPED COUNTRIES; DEVELOPING COUNTRIES; FEMALE; HETEROSEXUALITY; HIV INFECTIONS; HIV-1; HUMANS; MALE; MODELS, STATISTICAL; POISSON DISTRIBUTION; REGRESSION ANALYSIS;

EID: 84871756688     PISSN: 10443983     EISSN: 15315487     Source Type: Journal    
DOI: 10.1097/EDE.0b013e318276cad7     Document Type: Review

References (85)

1. UNAIDS/WHO. Global HIV/AIDS response. Epidemic update and health sector progress towards Universal Access (Progress report 2011). Available at: http://www.who.int/hiv/pub/progress-report2011/summary-en.pdf. Accessed 21 April 2012.
2. Granich RM, Gilks CF, Dye C, De Cock KM, Williams BG. Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. Lancet. 2009;373:48-57.
3. Cohen MS, Chen YQ, McCauley M, et al. HPTN 052 Study Team. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365:493-505.
4. Shiboski SC, Padian NS. Epidemiologic evidence for time variation in HIV infectivity. J Acquir Immune Defic Syndr Hum Retrovirol. 1998;19:527-535.
5. Shiboski SC, Jewell NP. Statistical analysis of the time dependence of HIV infectivity based on partner study data. J Am Stat Assoc 1992;87:360-372.
6. Boily MC, Baggaley RF, Wang L, et al. Heterosexual risk of HIV-1 infection per sexual act: systematic review and meta-analysis of observational studies. Lancet Infect Dis. 2009;9:118-129.
7. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA. 2000;283:2008-2012. (Pubitemid 30214957)
8. Baggaley RF, White RG, Boily MC. HIV transmission risk through anal intercourse: systematic review, meta-analysis and implications for HIV prevention. Int J Epidemiol. 2010;39:1048-1063.
9. Baggaley RF, Boily MC, White RG, Alary M. Risk of HIV-1 transmission for parenteral exposure and blood transfusion: a systematic review and meta-analysis. AIDS. 2006;20:805-812. (Pubitemid 43731561)
10. Baggaley RF, White RG, Boily MC. Systematic review of orogenital HIV-1 transmission probabilities. Int J Epidemiol. 2008;37:1255-1265.
11. Palella FJ, Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med. 1998;338:853-860. (Pubitemid 28135961)
12. UNAIDS/WHO. Progress on global access to HIV antiretroviral therapy. Available at: http://www.who.int/hiv/progressreport2006-en.pdf. Accessed 24 May 2011. 2006.
13. Thompson SG, Higgins JP. How should meta-regression analyses be undertaken and interpreted? Stat Med. 2002;21:1559-1573. (Pubitemid 34746063)
14. Cochran WG. The combination of estimates from different experiments. Biometrics 1954;10:101-29.
15. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557-560. (Pubitemid 37088507)
16. Waskett JH. Global circumcision rates (review). Circumcision Independent Reference and Commentary Service. Available at:http://www.circs.org/index.php/ Reviews/Rates/Global. Accessed 9 March 2012.
17. Musicco M, Lazzarin A, Nicolosi A, et al. Antiretroviral treatment of men infected with human immunodeficiency virus type 1 reduces the incidence of heterosexual transmission. Italian Study Group on HIV Heterosexual Transmission. Arch Intern Med. 1994;154:1971-1976. (Pubitemid 24276382)
18. Melo MG, Santos BR, De Cassia Lira R, et al. Sexual transmission of HIV-1 among serodiscordant couples in Porto Alegre, southern Brazil. Sex Transm Dis. 2008;35:912-915.
19. Watera C, Mutonyi G, Levin J, Birabwa E, Bawulira F, Vudriko T, et al. Changes in reported sexual behaviour and incidence of HIV infection in a cohort of HIV discordant couples in Kampala, Uganda. 5th Conference on HIV Pathogenesis and Treatment and Prevention, Cape Town. Abstract MOPEC005. 2009.
20. Sullivan P, Kayitenkore K, Chomba E, et al. Is the reduction of HIV transmission risk while prescribed antiretroviral therapy (ARVT) different for men and women? Results from discordant couples in Rwanda and Zambia. 5th IAS Conference on HIV Pathogenesis and Treatment. Abstract WEAC101. 2009.
21. Sullivan P, Kayitenkore K, Chomba E, et al. Reduction of HIV transmission risk and high risk sex while prescribed ART: results from discordant couples in Rwanda and Zambia. 16th Conference on Retroviruses and Opportunistic Infections. Abstract 52bLB. Montreal, 8-11 February 2009. Montreal, Canada. 2009.
22. Del Romero J, Castilla J, Hernando V, Rodríguez C, García S. Combined antiretroviral treatment and heterosexual transmission of HIV-1: cross sectional and prospective cohort study. BMJ. 2010;340:c2205.
23. Wang L, Ge Z, Luo J, Shan D, Gao X, Ding G-W, et al. HIV transmission risk among serodiscordant couples: a retrospective study of former plasma donors in Henan, China. JAIDS 2010;55:232-238.
24. Donnell D, Baeten JM, Kiarie J, et al. Partners in Prevention HSV/HIV Transmission Study Team. Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis. Lancet. 2010;375:2092-2098.
25. Reynolds SJ, Makumbi F, Nakigozi G, et al. HIV-1 transmission among HIV-1 discordant couples before and after the introduction of antiretroviral therapy. AIDS. 2011;25:473-477.
26. Allen S, Tice J, Van de Perre P, et al. Effect of serotesting with counselling on condom use and seroconversion among HIV discordant couples in Africa. BMJ. 1992;304:1605-1609.
27. Carpenter LM, Kamali A, Ruberantwari A, Malamba SS, Whitworth JA. Rates of HIV-1 transmission within marriage in rural Uganda in relation to the HIV sero-status of the partners. AIDS. 1999;13:1083-1089. (Pubitemid 29361399)
28. Celum C, Wald A, Lingappa JR, et al. Partners in Prevention HSV/HIV Transmission Study Team. Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2. N Engl J Med. 2010;362:427-439.
29. de Vincenzi I. A longitudinal study of human immunodeficiency virus transmission by heterosexual partners. European Study Group on Heterosexual Transmission of HIV. N Engl J Med. 1994;331:341-346. (Pubitemid 24233852)
30. Deschamps MM, Pape JW, Hafner A, Johnson WD Jr. Heterosexual transmission of HIV in Haiti. Ann Intern Med. 1996;125:324-330. (Pubitemid 126449279)
31. Fideli US, Allen SA, Musonda R, et al. Virologic and immunologic determinants of heterosexual transmission of human immunodeficiency virus type 1 in Africa. AIDS Res Hum Retroviruses. 2001;17:901-910. (Pubitemid 32881333)
32. Fischl MA, Dickinson GM, Scott GB, Klimas N, Fletcher MA, Parks W. Evaluation of heterosexual partners, children, and household contacts of adults with AIDS. JAMA. 1987;257:640-644. (Pubitemid 17015189)
33. Hira SK, Kamanga J, Macuacua R, Mwansa N, Cruess DF, Perine PL. Genital ulcers and male circumcision as risk factors for acquiring HIV-1 in Zambia. J Infect Dis. 1990;161:584-585. (Pubitemid 20107969)
34. Hugonnet S, Mosha F, Todd J, et al. Incidence of HIV infection in stable sexual partnerships: a retrospective cohort study of 1802 couples in Mwanza Region, Tanzania. J Acquir Immune Defic Syndr. 2002;30:73-80. (Pubitemid 34506690)
35. Laurian Y, Peynet J, Verroust F. HIV infection in sexual partners of HIV-seropositive patients with hemophilia. N Engl J Med. 1989;320:183. (Pubitemid 19033100)
36. Lawrence DN, Jason JM, Holman RC, Heine P, Evatt BL. Sex practice correlates of human immunodeficiency virus transmission and acquired immunodeficiency syndrome incidence in heterosexual partners and offspring of U.S. hemophilic men. Am J Hematol. 1989;30:68-76. (Pubitemid 19043007)
37. Lusher JM, Operskalski EA, Aledort LM, et al. Risk of human immunodeficiency virus type 1 infection among sexual and nonsexual household contacts of persons with congenital clotting disorders. Pediatrics. 1991;88:242-249.
38. Mao YR, Zheng XW, Re ZY, et al. [An epidemiological study on sexual transmission of human immunodeficiency virus among pre-marital group in Yining city, Xinjiang]. Zhonghua Liu Xing Bing Xue Za Zhi. 2004;25:322-324.
39. Mehendale SM, Ghate MV, Kishore Kumar B, et al. Low HIV-1 incidence among married serodiscordant couples in Pune, India. J Acquir Immune Defic Syndr. 2006;41:371-373.
40. O'Brien TR, Busch MP, Donegan E, et al. Heterosexual transmission of human immunodeficiency virus type 1 from transfusion recipients to their sex partners. J Acquir Immune Defic Syndr. 1994;7:705-710.
41. Operskalski EA, Stram DO, Busch MP, et al. Role of viral load in heterosexual transmission of human immunodeficiency virus type 1 by blood transfusion recipients. Transfusion Safety Study Group. Am J Epidemiol. 1997;146:655-661. (Pubitemid 27454553)
42. Padian NS, Shiboski SC, Glass SO, Vittinghoff E. Heterosexual transmission of human immunodeficiency virus (HIV) in northern California: results from a ten-year study. Am J Epidemiol. 1997;146:350-357.
43. Quinn TC, Wawer MJ, Sewankambo N, et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group. N Engl J Med. 2000;342:921-929. (Pubitemid 30177052)
44. Ragni MV, Faruki H, Kingsley LA. Heterosexual HIV-1 transmission and viral load in hemophilic patients. J Acquir Immune Defic Syndr Hum Retrovirol. 1998;17:42-45.
45. Rockstroh JK, Ewig S, Bauer T, et al. Male-to-female transmission of HIV in a cohort of hemophiliacs-frequency, risk factors and effect of sexual counseling. Infection. 1995;23:29-32.
46. Roth DL, Stewart KE, Clay OJ, et al. Sexual practices of HIV discordant and concordant couples in Rwanda: effects of a testing and counselling programme for men. Int J STD AIDS. 2001;12:181-188. (Pubitemid 32226176)
47. Ryder RW, Kamenga C, Jingu M, Mbuyi N, Mbu L, Behets F. Pregnancy and HIV-1 incidence in 178 married couples with discordant HIV-1 serostatus: additional experience at an HIV-1 counselling centre in the Democratic Republic of the Congo. Trop Med Int Health. 2000;5:482-487. (Pubitemid 30622526)
48. Senkoro KP, Boerma JT, Klokke AH, et al. HIV incidence and HIV-associated mortality in a cohort of factory workers and their spouses in Tanzania, 1991 through 1996. J Acquir Immune Defic Syndr. 2000;23:194-202. (Pubitemid 30316845)
49. Serwadda D, Gray RH, Wawer MJ, et al. The social dynamics of HIV transmission as reflected through discordant couples in rural Uganda. AIDS. 1995;9:745-750.
50. Siddiqui NS, Brown LS Jr, Phillips RY, Vargas O, Makuch RW. No seroconversions among steady sex partners of methadone-maintained HIV-1-seropositive injecting drug users in New York City. AIDS. 1992;6:1529-1533. (Pubitemid 23011865)
51. Tovanabutra S, Robison V, Wongtrakul J, et al. Male viral load and heterosexual transmission of HIV-1 subtype E in northern Thailand. J Acquir Immune Defic Syndr. 2002;29:275-283. (Pubitemid 34208536)
52. van der Ende ME, Rothbarth P, Stibbe J. Heterosexual transmission of HIV by haemophiliacs. BMJ. 1988;297:1102-1103.
53. Wawer MJ, Makumbi F, Kigozi G, et al. Circumcision in HIV-infected men and its effect on HIV transmission to female partners in Rakai, Uganda: a randomised controlled trial. Lancet. 2009;374:229-237.
54. Zhang H, Wu H, Xu L. Behavior interventions and health education for HIV-infected people and their spouses. Chin J AIDS STD (Chin). 2001;7:286-288.
55. El-Bassel N, Jemmott JB, Landis JR, et al. NIMH Multisite HIV/STD Prevention Trial for African American Couples Group. National Institute of Mental Health Multisite Eban HIV/STD Prevention Intervention for African American HIV Serodiscordant Couples: a cluster randomized trial. Arch Intern Med. 2010;170:1594-1601.
56. Kumarasamy N, Venkatesh KK, Srikrishnan AK, et al. Risk factors for HIV transmission among heterosexual discordant couples in South India. HIV Med. 2010;11:178-186.
57. Robertson JR, Wyld R, Elton R, Brettle RP. Heterosexual transmission of HIV in men and women in a Scottish cohort. AIDS. 1998;12:823-824. (Pubitemid 28190710)
58. Rojanawiwat A, Ariyoshi K, Pathipvanich P, Tsuchiya N, Auwanit W, Sawanpanylaert P. Substantially exposed but HIV-negative individuals are accumulated in HIV-serology-discordant couples diagnosed in a referral hospital in Thailand. Jpn J Infect Dis. 2009;62:32-36.
59. Saracco A, Veglia F, Lazzarin A. Risk of HIV-1 transmission in heterosexual stable and random couples. The Italian Partner Study. J Biol Regul Homeost Agents. 1997;11:3-6. (Pubitemid 27503816)
60. Glynn J, Price A, Floyd S, et al. Antiretroviral therapy reduces HIV transmission in discordant couples in Northern Malawi. 19th International Society of Sexually Transmitted Research Conference, Quebec, Canada, July 2011. Abstract P1-S6.53. STI 2011;87(suppl 1):A218.
61. Muwonge T, Namimbi F, Bakabulindi P, Wakabi L, Weguli S, Kambugu A. Low HIV sero-conversion rates among HIV discordant couples attending a large urban HIV clinic in Uganda. 6th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention, Rome, Italy, July 2011. Abstract CDC335. 2011.
62. Guthrie B, Choi R, Bosire R, et al. Low rates of HIV-1 transmission in a cohort of discordant couples in Nairobi, Kenya. 6th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention, Rome, Italy, July 2011. Abstract MOPE330. 2011.
63. Apondi R, Bunnell R, Ekwaru JP, et al. Sexual behavior and HIV transmission risk of Ugandan adults taking antiretroviral therapy: 3 year follow-up. AIDS. 2011;25:1317-1327.
64. Li JY, Li L, Li H, et al. [Cohort study on human immunodeficiency virus discordant couples in the countryside of central China]. Zhonghua Liu Xing Bing Xue Za Zhi. 2006;27:192-195.
65. Duan S, Yang YC, Xiang LF, et al. [Incidence and risk factors of HIV infection among sero-negative spouses of HIV patients in Dehong prefecture of Yunnan province]. Zhonghua Liu Xing Bing Xue Za Zhi. 2010;31:997-1000.
66. Pan XH, Yang JZ, Chen L, Xu Y. [Analysis of epidemiological characteristics of HIV infections among immigrant marriage women in rural areas in Zhejiang province]. Zhonghua Yu Fang Yi Xue Za Zhi. 2010;44:1023-1026.
67. Baeten J, Celum C, Team obotPPS. Antiretroviral pre-exposure prophylaxis for HIV-1 prevention among heterosexual African men and women: the Partners PrEP study. 6th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention, Rome, Italy, July 2011. Abstract MOAX0106. Available at: http://pag.ias2011.org/flash.aspx?pid=886.2011. Accessed 1 August 2011.
68. Reynolds S, Makumbi F, Kagaayi J, et al. ART reduced the rate of sexual transmission of HIV among HIV-discordant couples in rural Rakai, Uganda. 16th Conference on Retroviruses and Opportunistic Infections. Abstract 52a. Montreal, 8-11 February 2009. Montreal, Canada. 2009.
69. Hira SK, Feldblum PJ, Kamanga J, Mukelabai G, Weir SS, Thomas JC. Condom and nonoxynol-9 use and the incidence of HIV infection in serodiscordant couples in Zambia. Int J STD AIDS. 1997;8:243-250. (Pubitemid 27192079)
70. Attia S, Egger M, Müller M, Zwahlen M, Low N. Sexual transmission of HIV according to viral load and antiretroviral therapy: systematic review and meta-analysis. AIDS. 2009;23:1397-1404.
71. Hughes J, Baeten J, Lingappa J, et al. Determinants of per-act infectivity of HIV-1 in the Partners in Prevention Study. Eighteenth Conference on Retroviruses and Opportunistic Infections (CROI), Boston. Abstract 135. Available at: http://www.retroconference.org/2011/Abstracts/41932.htm. Accessed 26 May 2011.
72. Baeten J, Kahle E, Lingappa J, et al. Genital HIV-1 RNA levels predict risk of heterosexual HIV-1 transmission. Eighteenth Conference on Retroviruses and Opportunistic Infections (CROI), Boston. Abstract 154. Available at: http://www.retroconference.org/2011/Abstracts/40117.htm. Accessed 26 May 2011.
73. Wawer MJ, Gray RH, Sewankambo NK, et al. Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda. J Infect Dis. 2005;191:1403-1409. (Pubitemid 40563350)
74. Cohen J. Differences in HIV strains may underlie disease patterns. Science. 1995;270:30-31.
75. Cameron DW, Simonsen JN, D'Costa LJ, et al. Female to male transmission of human immunodeficiency virus type 1: risk factors for seroconversion in men. Lancet. 1989;2:403-407. (Pubitemid 19195957)
76. Nicolosi A, Corrêa Leite ML, Musicco M, et al. The efficiency of male-to-female and female-to-male sexual transmission of the human immunodeficiency virus: a study of 730 stable couples. Italian Study Group on HIV Heterosexual Transmission. Epidemiology. 1994;5:570-575. (Pubitemid 24336507)
77. Cameron DW, Simonsen JN, D'Costa LJ, et al. Genital ulcer disease and lack of male circumcision facilitate female to male sexual HIV transmission. The Lancet 1989;2:403-407.
78. Catania JA, Gibson DR, Chitwood DD, Coates TJ. Methodological problems in AIDS behavioral research: influences on measurement error and participation bias in studies of sexual behavior. Psychol Bull. 1990;108:339-362.
79. Angell M. Investigators' responsibilities for human subjects in developing countries. N Engl J Med. 2000;342:967-969. (Pubitemid 30177058)
80. Cohen MS, Gay C, Kashuba AD, Blower S, Paxton L. Narrative review: antiretroviral therapy to prevent the sexual transmission of HIV-1. Ann Intern Med. 2007;146:591-601. (Pubitemid 351650540)
81. Cohen MS, Gay CL. Treatment to prevent transmission of HIV-1. Clin Infect Dis. 2010;50(suppl 3):S85-S95.
82. Bezemer D, de Wolf F, Boerlijst MC, et al. A resurgent HIV-1 epidemic among men who have sex with men in the era of potent antiretroviral therapy. AIDS. 2008;22:1071-1077. (Pubitemid 351769746)
83. Garnett GP, Anderson RM. Antiviral therapy and the transmission dynamics of HIV-1. J Antimicrob Chemother. 1996;37(suppl B):135-150. (Pubitemid 26283315)
84. Abdool Karim Q, Abdool Karim SS, Frohlich JA, et al. CAPRISA 004 Trial Group. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science. 2010;329:1168-1174.
85. Anglemyer A, Rutherford GW, Baggaley RC, Egger M, Siegfried N. Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples. Cochrane Database of Systematic Reviews. 2011: CD009153. doi: 10.1002/14651858.CD009153.pub2.