The Toxoplasma MAG1 peptides induce sex-based humoral immune response in mice and distinguish active from chronic human infection

Microbes and Infection

Volumn 15, Issue 1, 2013, Pages 74-83

  Xiao, Jianchun ^a   Viscidi, Raphael P ^a   Kannan, Geetha ^a   Pletnikov, Mikhail V ^a   Li, Ye ^a,b   Severance, Emily G ^a   Yolken, Robert H ^a   Delhaes, Laurence ^c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^c UNIV LILLE   (France)

Author keywords

Diagnostic marker; Early immune response; MAG1_4; MAG1_5; Sex difference

Indexed keywords

ANTIGEN; MAG1 ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMORAL IMMUNITY; IMMUNOREACTIVITY; MALE; MOUSE; NONHUMAN; PILOT STUDY; PRIORITY JOURNAL; SEROCONVERSION; SEX DIFFERENCE; TOXOPLASMA GONDII; TOXOPLASMOSIS; VALIDATION STUDY;

AMINO ACID SEQUENCE; ANALYSIS OF VARIANCE; ANIMALS; ANTIBODIES, PROTOZOAN; ASYMPTOMATIC INFECTIONS; BIOLOGICAL MARKERS; CHRONIC DISEASE; FEMALE; HUMANS; MALE; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTOZOAN PROTEINS; SEX FACTORS; TOXOPLASMA; TOXOPLASMOSIS;

MUS; TOXOPLASMA; TOXOPLASMA GONDII;

EID: 84871738330     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2012.10.016     Document Type: Article

References (24)

1. Liesenfeld O., Montoya J.G., Tathineni N.J., Davis M., Brown B.W., Cobb K.L., Parsonnet J., Remington J.S. Confirmatory serologic testing for acute toxoplasmosis and rate of induced abortions among women reported to have positive Toxoplasma immunoglobulin M antibody titers. Am. J. Obstet. Gynecol. 2001, 184:140-145.
2. Roberts A., Hedman K., Luyasu V., Zufferey J., Bessières M.H., Blatz R.M., Candolfi E., Decoster A., Enders G., Gross U., Guy E., Hayde M., Ho-Yen D., Johnson J., Lécolier B., Naessens A., Pelloux H., Thulliez P., Petersen E. Multicenter evaluation of strategies for serodiagnosis of primary infection with Toxoplasma gondii. Eur. J. Clin. Microbiol. Infect. Dis. 2001, 20:467-474.
3. Petersen E., Borobio M.V., Guy E., Liesenfeld O., Meroni V., Naessens A., Spranzi E., Thulliez P. European multicenter study of the LIAISON automated diagnostic system for determination of Toxoplasma gondii-specific immunoglobulin G (IgG) and IgM and the IgG avidity index. J. Clin. Microbiol. 2005, 43:1570-1574.
4. Di Cristina M., Del Porto P., Buffolano W., Beghetto E., Spadoni A., Guglietta S., Piccolella E., Felici F., Gargano N. The Toxoplasma gondii bradyzoite antigens BAG1 and MAG1 induce early humoral and cell-mediated immune responses upon human infection. Microbes Infect. 2004, 6:164-171.
5. Holec L., Hiszczyńska-Sawicka E., Gasior A., Brillowska-Dabrowska A., Kur J. Use of MAG1 recombinant antigen for diagnosis of Toxoplasma gondii infection in humans. Clin. Vaccine Immunol. 2007, 14:220-225.
6. Pfrepper K.I., Enders G., Gohl M., Krczal D., Hlobil H., Wassenberg D., Soutschek E. Seroreactivity to and avidity for recombinant antigens in toxoplasmosis. Clin. Diagn. Lab. Immunol. 2005, 12:977-982.
7. Ajzenberg D., Yera H., Marty P., Paris L., Dalle F., Menotti J., Aubert D., Franck J., Bessières M.H., Quinio D., Pelloux H., Delhaes L., Desbois N., Thulliez P., Robert-Gangneux F., Kauffmann-Lacroix C., Pujol S., Rabodonirina M., Bougnoux M.E., Cuisenier B., Duhamel C., Duong T.H., Filisetti D., Flori P., Gay-Andrieu F., Pratlong F., Nevez G., Totet A., Carme B., Bonnabau H., Dardé M.L., Villena I. Genotype of 88 Toxoplasma gondii isolates associated with toxoplasmosis in immunocompromised patients and correlation with clinical findings. J. Infect. Dis. 2009, 199:1155-1167.
8. Delhaes L., Mraz J.C., Fréalle E., Durand-Joly I., Magro L., Ajzenberg D., Dardé M.L., Dei-Cas E., Yakoub-Agha I. Severe pulmonary toxoplasmosis after allo-SCT in two patients: from Toxoplasma genotyping to clinical management. Bone Marrow Transplant. 2010, 45:580-583.
9. Dubey J.P., Lindsay D.S., Speer C.A. Structures of Toxoplasma gondii tachyzoites, bradyzoites, and sporozoites and biology and development of tissue cysts. Clin. Microbiol. Rev. 1998, 11:267-299.
10. Kim S.K., Boothroyd J.C. Stage-specific expression of surface antigens by Toxoplasma gondii as a mechanism to facilitate parasite persistence. J. Immunol. 2005, 174:8038-8048.
11. Huynh M.H., Carruthers V.B. Toxoplasma MIC2 is a major determinant of invasion and virulence. PLoS Pathog. 2006, 2:e84.
12. Xiao J., Buka S.L., Cannon T.D., Suzuki Y., Viscidi R.P., Torrey E.F., Yolken R.H. Serological pattern consistent with infection with type I Toxoplasma gondii in mothers and risk of psychosis among adult offspring. Microbes Infect. 2009, 11:1011-1018.
13. Homan W.L., Vercammen M., De Braekeleer J., Verschueren H. Identification of a 200- to 300-fold repetitive 529 bp DNA fragment in Toxoplasma gondii, and its use for diagnostic and quantitative PCR. Int. J. Parasitol. 2000, 30:69-75.
14. Reischl U., Bretagne S., Krüger D., Ernault P., Costa J.M. Comparison of two DNA targets for the diagnosis of Toxoplasmosis by real-time PCR using fluorescence resonance energy transfer hybridization probes. BMC Infect. Dis. 2003, 3:7.
15. Simon A., Labalette P., Ordinaire I., Frealle E., Dei-Cas E., Camus D., Delhaes L. Use of fluorescence resonance energy transfer hybridization probes to evaluate quantitative real-time PCR for diagnosis of ocular toxoplasmosis. J. Clin. Microbiol. 2004, 42:3681-3685.
16. Sterkers Y., Varlet-Marie E., Cassaing S., Brenier-Pinchart M.P., Brun S., Dalle F., Delhaes L., Filisetti D., Pelloux H., Yera H., Bastien P. Multicentric comparative analytical performance study for molecular detection of low amounts of Toxoplasma gondii from simulated specimens. J. Clin. Microbiol. 2010, 48:3216-3222.
17. Yera H., Filisetti D., Bastien P., Ancelle T., Thulliez P., Delhaes L. Multicenter comparative evaluation of five commercial methods for toxoplasma DNA extraction from amniotic fluid. J. Clin. Microbiol. 2009, 47:3881-3886.
18. Parmley S.F., Yang S., Harth G., Sibley L.D., Sucharczuk A., Remington J.S. Molecular characterization of a 65-kilodalton Toxoplasma gondii antigen expressed abundantly in the matrix of tissue cysts. Mol. Biochem. Parasitol. 1994, 66:283-296.
19. Ferguson D.J., Parmley S.F. Toxoplasma gondii MAG1 protein expression. Trends Parasitol. 2002, 18:482.
20. Liesenfeld O., Nguyen T.A., Pharke C., Suzuki Y. Importance of gender and sex hormones in regulation of susceptibility of the small intestine to peroral infection with Toxoplasma gondii tissue cysts. J. Parasitol. 2001, 87:1491-1493.
21. Roberts C.W., Cruickshank S.M., Alexander J. Sex-determined resistance to Toxoplasma gondii is associated with temporal differences in cytokine production. Infect. Immun. 1995, 63:2549-2555.
22. Meroni V., Genco F., Tinelli C., Lanzarini P., Bollani L., Stronati M., Petersen E. Spiramycin treatment of Toxoplasma gondii infection in pregnant women impairs the production and the avidity maturation of T. gondii-specific immunoglobulin G antibodies. Clin. Vaccine Immunol. 2009, 16:1517-1520.
23. Grigg M.E., Ganatra J., Boothroyd J.C., Margolis T.P. Unusual abundance of atypical strains associated with human ocular toxoplasmosis. J. Infect. Dis. 2001, 184:633-639.
24. Delhaes L., Ajzenberg D., Sicot B., Bourgeot P., Darde M.L., Dei-Cas E., Houfflin-Debarge V. Severe congenital toxoplasmosis due to a Toxoplasma gondii strain with an atypical genotype: case report and review. Prenatal Diagn. 2010, 30:902-905.