Synthesis and antimycobacterial evaluation of pyrazinamide derivatives with benzylamino substitution

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 2, 2013, Pages 476-479

  Zitko, Jan ^a   Paterová, Pavla ^b   Kubíček, Vladimír ^a   Mandíková, Jana ^a   Trejtnar, František ^a   Kuneš, Jiří ^a   Doležal, Martin ^a  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

Author keywords

Antimycobacterial activity; Benzylamines; Cytotoxicity; Lipophilicity; Pyrazinamide derivatives

Indexed keywords

ANTIMYCOBACTERIAL AGENT; ISONIAZID; PYRAZINAMIDE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LIVER TOXICITY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM AVIUM; MYCOBACTERIUM KANSASII; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ANTITUBERCULAR AGENTS; BENZYLAMINES; CELLS, CULTURED; HUMANS; INHIBITORY CONCENTRATION 50; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM; PYRAZINAMIDE;

MYCOBACTERIUM AVIUM; MYCOBACTERIUM KANSASII; MYCOBACTERIUM TUBERCULOSIS;

EID: 84871721752     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.11.052     Document Type: Article

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