Flash responses of mouse rod photoreceptors in the isolated retina and corneal electroretinogram: Comparison of gain and kinetics

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 9, 2012, Pages 5653-5664

  Heikkinen, Hanna ^a   Vinberg, Frans ^a   Pitkänen, Marja ^a   Kommonen, Bertel ^b   Koskelainen, Ari ^a  

^a AALTO UNIVERSITY   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

VISUAL PIGMENT; 2 AMINO 4 PHOSPHONOBUTYRIC ACID; 2-AMINO-4-PHOSPHONOBUTYRIC ACID; AMINOBUTYRIC ACID DERIVATIVE; ANESTHETIC AGENT; BARIUM CHLORIDE; BARIUM DERIVATIVE; CHLORIDE; HYPNOTIC SEDATIVE AGENT; KETAMINE; XYLAZINE;

A WAVE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRORETINOGRAPHY; LIGHT EXPOSURE; MOUSE; NONHUMAN; PHOTOTRANSDUCTION; PRIORITY JOURNAL; RETINA ROD; VISUAL STIMULATION; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; COMPARATIVE STUDY; CORNEA; DARK ADAPTATION; DRUG EFFECT; KINETICS; METHODOLOGY; ORGAN CULTURE TECHNIQUE; PHOTOSTIMULATION; PHYSIOLOGY; PIGMENT EPITHELIUM;

AMINOBUTYRATES; ANESTHETICS, DISSOCIATIVE; ANIMALS; BARIUM COMPOUNDS; CHLORIDES; CORNEA; DARK ADAPTATION; ELECTRORETINOGRAPHY; HYPNOTICS AND SEDATIVES; KETAMINE; KINETICS; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; ORGAN CULTURE TECHNIQUES; PHOTIC STIMULATION; RETINAL PIGMENT EPITHELIUM; RETINAL PIGMENTS; RETINAL ROD PHOTORECEPTOR CELLS; XYLAZINE;

EID: 84871710149     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-9678     Document Type: Article

References (58)

1. Küchler G, Pilz A, Sickel W, Bauereisen E. Sauerstoffdruck und b-Welle des Elektroretinogramms vom isolierten Froschauge. Pflugers Archiv-Eur J Physiol. 1956;263:566-576.
2. Ames A III, Gurian BS. Measurement of function in an in vitro preparation of mammalian central nervous tissue. J Neurophysiol. 1960;23:676-691.
3. Ames A III, Gurian BS. Recording of single unit activity in isolated central nervous tissue. Science. 1961;133:1767-1768.
4. Detwiler PB, Conner JD, Bodoia RD. Gigaseal patch clamp recordings from outer segments of intact retinal rods. Nature. 1982;300:59-61.
5. Sather WA, Detwiler PB. Intracellular biochemical manipulation of phototransduction in detached rod outer segments. Proc Natl Acad Sci U S A. 1987;84:9290-9294.
6. Baylor DA, Lamb TD, Yau KW. The membrane current of single rod outer segments. J Physiol. 1979;288:589-611.
7. Heikkinen H, Nymark S, Koskelainen A. Mouse cone photoresponses obtained with electroretinogram from the isolated retina. Vision Res. 2008;48:264-272.
8. Green DG. Visual resolution when light enters the eye through different parts of the pupil. J Physiol. 1967;190:583-593.
9. Green DG, Kapousta-Bruneau NV. Electrophysiological properties of a new isolated rat retina preparation. Vision Res. 1999;39:2165-2177.
10. Wang JS, Estevez ME, Cornwall MC, Kefalov VJ. Intra-retinal visual cycle required for rapid and complete cone dark adaptation. Nat Neurosci. 2009;12:295-302.
11. Azevedo AW, Rieke F. Experimental protocols alter phototransduction: the implications for retinal processing at visual threshold. J Neurosci. 2011;31:3670-3682.
12. Naarendorp F, Esdaille TM, Banden SM, Andrews-Labenski J, Gross OP, Pugh EN Jr. Dark light, rod saturation, and the absolute and incremental sensitivity of mouse cone vision. J Neurosci. 2010;12495-12507.
13. Fu Y, Yau KW. Phototransduction in mouse rods and cones. Pflugers Arch. 2007;454:805-819.
14. Burns ME, Pugh EN Jr. Lessons from photoreceptors: turning off g-protein signaling in living cells. Physiology (Bethesda). 2010;25:72-84.
15. Fain GL. Adaptation of mammalian photoreceptors to background light: putative role for direct modulation of phosphodiesterase. Mol Neurobiol. 2011;44:374-382.
16. Kefalov VJ. Rod and cone visual pigments and phototransduction through pharmacological, genetic, and physiological approaches. J Biol Chem. 2012;287:1635-1641.
17. Doan T, Azevedo AW, Hurley JB, Rieke F. Arrestin competition influences the kinetics and variability of the single-photon responses of mammalian rod photoreceptors. J Neurosci. 2009;29:11867-11879.
18. Gross OP, Burns ME. Control of rhodopsin's active lifetime by arrestin-1 expression in mammalian rods. J Neurosci. 2010;30: 3450-3457.
19. Heikkinen H, Vinberg F, Nymark S, Koskelainen A. Mesopic background lights enhance dark-adapted cone ERG flash responses in the intact mouse retina: a possible role for gap junctional decoupling. J Neurophysiol. 2011;105:2309-2318.
20. Nymark S, Haldin C, Tenhu H, Koskelainen A. A new method for measuring free drug concentration: retinal tissue as a biosensor. Invest Ophthalmol Vis Sci. 2006;47:2583-2588.
21. Lyubarsky AL, Daniele LL, Pugh EN Jr. From candelas to photoisomerizations in the mouse eye by rhodopsin bleaching in situ and the light-rearing dependence of the major components of the mouse ERG. Vision Res. 2004;44:3235-3251.
22. Nymark S, Heikkinen H, Haldin C, Donner K, Koskelainen A. Light responses and light adaptation in rat retinal rods at different temperatures. J Physiol. 2005;567:923-938.
23. Govardovskii VI, Fyhrquist N, Reuter T, Kuzmin DG, Donner K. In search of the visual pigment template. Vis Neurosci. 2000;17:509-528.
24. Pepperberg DR, Birch DG, Hood DC. Photoresponses of human rods in vivo derived from paired-flash electroretinograms. Vis Neurosci. 1997;14:73-82.
25. Friedburg C, Thomas MM, Lamb TD. Time course of the flash response of dark-and light-adapted human rod photoreceptors derived from the electroretinogram. J Physiol. 2001;534:217-242.
26. Hetling JR, Pepperberg DR. Sensitivity and kinetics of mouse rod flash responses determined in vivo from paired-flash electroretinograms. J Physiol. 1999;516:593-609.
27. Green DG, Kapousta-Bruneau NV. A dissection of the electroretinogram from the isolated rat retina with microelectrodes and drugs. Vis Neurosci. 1999;16:727-741.
28. Lamb TD, Pugh EN Jr. A quantitative account of the activation steps involved in phototransduction in amphibian photoreceptors. J Physiol. 1992;449:719-758.
29. Lyubarsky AL, Pugh EN Jr. Recovery phase of the murine rod photoresponse reconstructed from electroretinographic recordings. J Neurosci. 1996;16:563-571.
30. Green DG, Guo H, Pillers DA. Normal photoresponses and altered b-wave responses to APB in the mdx(Cv3) mouse isolated retina ERG supports role for dystrophin in synaptic transmission. Vis Neurosci. 2004;21:739-747.
31. Sharif SI, Abouazra HA. Effects of intravenous ketamine administration on blood glucose levels in conscious rabbits. Am J Pharmacol Toxicol. 2009;4:38-45.
32. Brown ET, Umino Y, Solessio E, Loi T, Quinn R, Barlow R. Anesthesia affects mouse ERG and blood glucose. Vis Neurosci. 22:615-618.
33. Kang Derwent JJ, Saszik SM, Maeda H, et al. Test of the pairedflash electroretinographic method in mice lacking b-waves. Vis Neurosci. 2007;24:141-149.
34. Schnapf JL. Dependence of the single photon response on longitudinal position of absorption in toad rod outer segments. J Physiol. 1983;343:147-159.
35. Mueller P, Pugh EN Jr, Pugh EN. Protons block the dark current of isolated retinal rods. Proc Natl Acad Sci U S A. 1983;80: 1892-1896.
36. Lamb TD. Effects of temperature changes on toad rod photocurrents. J Physiol. 1984;346:557-578.
37. Lamb TD. Keynote lecture: the cellular origin of different components of the electroretinogram. Doc Ophthalmol. 2010; 121(suppl 1):14.
38. Robson JG, Frishman LJ. The a-wave: contribution of capacitive currents. Doc Ophthalmol. 2010;121(suppl 1):14.
39. Strauss O. The retinal pigment epithelium in visual function. Physiol Rev. 2005;85:845-881.
40. Steinberg RH, Schmidt R, Brown KT. Intracellular responses to light from cat pigment epithelium: origin of the electroretinogram c-wave. Nature. 1970;227:728-730.
41. Oakley B. Potassium and the photoreceptor-dependent pigment epithelial hyperpolarization. J Gen Physiol. 1977; 70:405-425.
42. Wu J, Peachey NS, Marmorstein AD. Light-evoked responses of the mouse retinal pigment epithelium. J Neurophysiol. 2004; 91:1134-1142.
43. Donner KO, Hemilä S. Kinetics of long-lived rhodopsin photoproducts in the frog retina as a function of the amount bleached. Vision Res. 1975;15:985-995.
44. Chen X, Shu S, Bayliss DA. HCN1 channel subunits are a molecular substrate for hypnotic actions of ketamine. J Neurosci. 2009;29:600-609.
45. Cohen ML, Chan SL, Way WL, Trevor AJ. Distribution in the brain and metabolism of ketamine in the rat after intravenous administration. Anesthesiology. 1973;39:370-376.
46. Barrow AJ, Wu SM. Low-conductance HCN1 ion channels augment the frequency response of rod and cone photoreceptors. J Neurosci. 2009;29:5841-5853.
47. Hestrin S. The properties and function of inward rectification in rod photoreceptors of the tiger salamander. J Physiol. 1987; 390:319-333.
48. Demontis GC, Moroni A, Gravante B, et al. Functional characterisation and subcellular localisation of HCN1 channels in rabbit retinal rod photoreceptors. J Physiol. 2002;542:89-97.
49. Demontis GC, Longoni B, Barcaro U, Cervetto L. Properties and functional roles of hyperpolarization-gated currents in guinea-pig retinal rods. J Physiol. 1999;515:813-828.
50. Vinberg FJ, Strandman S, Koskelainen A. Origin of the fast negative ERG component from isolated aspartate-treated mouse retina. J Vis. 2009;9:9-17.
51. Malatinsky J, Vigas M, Jezova D, Jurcovicova J, Samel M, Vrsansky D. The effects of open heart surgery on growth hormone, cortisol and insulin levels in man. Hormone levels during open heart surgery. Resuscitation. 1984;11:57-68.
52. du Plooy WJ, Schutte PJ, Still J, Hay L, Kahler CP. Stability of cardiodynamic and some blood parameters in the baboon following intravenous anaesthesia with ketamine and diazepam. J S Afr Vet Assoc. 1998;69:18-21.
53. Reyes Toso CF, Linares LM, Rodriguez RR. Blood sugar concentrations during ketamine or pentobarbitone anesthesia in rats with or without alpha and beta adrenergic blockade. Medicina (B Aires). 1995;55:311-316.
54. Brown ET, Umino Y, Loi T, Solessio E, Barlow R. Anesthesia can cause sustained hyperglycemia in C57/BL6J mice. Vis Neurosci. 2005;22:615-618.
55. Holfort SK, Klemp K, Kofoed PK, Sander B, Larsen M. Scotopic electrophysiology of the retina during transient hyperglycemia in type 2 diabetes. Invest Ophthalmol Vis Sci. 2010;51:2790-2794.
56. Macaluso C, Onoe S, Niemeyer G. Changes in glucose level affect rod function more than cone function in the isolated, perfused cat eye. Invest Ophthalmol Vis Sci. 1992;33:2798-2808.
57. Kim SY, Nao-i N, Honda Y. Effects of glucose and fructose added to the intraocular irrigating solutions on the rabbit ERG in vitro. Metab Pediatr Syst Ophthalmol. 1987;10:14-17.
58. Mojumder DK, Wensel TG. Topical mydriatics affect lightevoked retinal responses in anesthetized mice. Invest Ophthalmol Vis Sci. 2010;51:567-576.