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Volumn 7, Issue 12, 2012, Pages

Functional Profiling of Live Melanoma Samples Using a Novel Automated Platform

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; MITOGEN ACTIVATED PROTEIN KINASE; N [3 (5 CHLORO 1H PYRROLO[2,3 B]PYRIDINE 3 CARBONYL) 2,4 DIFLUOROPHENYL]PROPANESULFONAMIDE;

EID: 84871709993     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052760     Document Type: Article
Times cited : (6)

References (34)
  • 1
    • 41649102043 scopus 로고    scopus 로고
    • The cancer biomarker problem
    • Sawyers CL, (2008) The cancer biomarker problem. Nature 452: 548-552.
    • (2008) Nature , vol.452 , pp. 548-552
    • Sawyers, C.L.1
  • 2
    • 77955602596 scopus 로고    scopus 로고
    • Visualizing the landscape of selection biomarkers in current phase III oncology clinical trials
    • Sikorski R, Yao B, (2010) Visualizing the landscape of selection biomarkers in current phase III oncology clinical trials. Sci Transl Med 2: 34ps27.
    • (2010) Sci Transl Med , vol.2
    • Sikorski, R.1    Yao, B.2
  • 3
    • 33644833555 scopus 로고    scopus 로고
    • Mapping normal and cancer cell signalling networks: towards single-cell proteomics
    • Irish JM, Kotecha N, Nolan GP, (2006) Mapping normal and cancer cell signalling networks: towards single-cell proteomics. Nat Rev Cancer 6: 146-155.
    • (2006) Nat Rev Cancer , vol.6 , pp. 146-155
    • Irish, J.M.1    Kotecha, N.2    Nolan, G.P.3
  • 4
    • 78951489049 scopus 로고    scopus 로고
    • Feedback regulation of EGFR signalling: decision making by early and delayed loops
    • Avraham R, Yarden Y, (2011) Feedback regulation of EGFR signalling: decision making by early and delayed loops. Nat Rev Mol Cell Biol 12: 104-117.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 104-117
    • Avraham, R.1    Yarden, Y.2
  • 5
    • 67650224645 scopus 로고    scopus 로고
    • Patient-specific classifications of human malignant disease
    • Parkinson DR, Cesano A, (2009) Patient-specific classifications of human malignant disease. Curr Opin Mol Ther 11: 252-259.
    • (2009) Curr Opin Mol Ther , vol.11 , pp. 252-259
    • Parkinson, D.R.1    Cesano, A.2
  • 6
    • 78650382003 scopus 로고    scopus 로고
    • Biologically targeted cancer therapy and marginal benefits: are we making too much of too little or are we achieving too little by giving too much?
    • Fojo T, Parkinson DR, (2010) Biologically targeted cancer therapy and marginal benefits: are we making too much of too little or are we achieving too little by giving too much? Clin Cancer Res 16: 5972-5980.
    • (2010) Clin Cancer Res , vol.16 , pp. 5972-5980
    • Fojo, T.1    Parkinson, D.R.2
  • 7
    • 78651394465 scopus 로고    scopus 로고
    • Bring on the biomarkers
    • Poste G, (2011) Bring on the biomarkers. Nature 469: 156-157.
    • (2011) Nature , vol.469 , pp. 156-157
    • Poste, G.1
  • 8
    • 84860214530 scopus 로고    scopus 로고
    • From genes to drugs: targeted strategies for melanoma
    • Flaherty KT, Hodi FS, Fisher DE, (2012) From genes to drugs: targeted strategies for melanoma. Nat Rev Cancer 12: 349-361.
    • (2012) Nat Rev Cancer , vol.12 , pp. 349-361
    • Flaherty, K.T.1    Hodi, F.S.2    Fisher, D.E.3
  • 9
    • 78650008177 scopus 로고    scopus 로고
    • Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
    • Villanueva J, Vultur A, Lee JT, Somasundaram R, Fukunaga-Kalabis M, et al. (2010) Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. Cancer Cell 18: 683-695.
    • (2010) Cancer Cell , vol.18 , pp. 683-695
    • Villanueva, J.1    Vultur, A.2    Lee, J.T.3    Somasundaram, R.4    Fukunaga-Kalabis, M.5
  • 10
    • 78650309875 scopus 로고    scopus 로고
    • COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
    • Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, et al. (2010) COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature 468: 968-972.
    • (2010) Nature , vol.468 , pp. 968-972
    • Johannessen, C.M.1    Boehm, J.S.2    Kim, S.Y.3    Thomas, S.R.4    Wardwell, L.5
  • 11
    • 78650303507 scopus 로고    scopus 로고
    • Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
    • Nazarian R, Shi H, Wang Q, Kong X, Koya RC, et al. (2010) Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature 468: 973-977.
    • (2010) Nature , vol.468 , pp. 973-977
    • Nazarian, R.1    Shi, H.2    Wang, Q.3    Kong, X.4    Koya, R.C.5
  • 13
    • 83455254767 scopus 로고    scopus 로고
    • RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
    • Poulikakos PI, Persaud Y, Janakiraman M, Kong X, Ng C, et al. (2011) RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature 480: 387-390.
    • (2011) Nature , vol.480 , pp. 387-390
    • Poulikakos, P.I.1    Persaud, Y.2    Janakiraman, M.3    Kong, X.4    Ng, C.5
  • 14
    • 84859183431 scopus 로고    scopus 로고
    • Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance
    • Shi H, Moriceau G, Kong X, Lee MK, Lee H, et al. (2012) Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance. Nat Commun 3: 724.
    • (2012) Nat Commun , vol.3 , pp. 724
    • Shi, H.1    Moriceau, G.2    Kong, X.3    Lee, M.K.4    Lee, H.5
  • 15
    • 84861863158 scopus 로고    scopus 로고
    • EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib
    • Corcoran RB, Ebi H, Turke AB, Coffee EM, Nishino M, et al. (2012) EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib. Cancer Discov 2: 227-235.
    • (2012) Cancer Discov , vol.2 , pp. 227-235
    • Corcoran, R.B.1    Ebi, H.2    Turke, A.B.3    Coffee, E.M.4    Nishino, M.5
  • 16
    • 84863230465 scopus 로고    scopus 로고
    • Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
    • Prahallad A, Sun C, Huang S, Di Nicolantonio F, Salazar R, et al. (2012) Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature 483: 100-103.
    • (2012) Nature , vol.483 , pp. 100-103
    • Prahallad, A.1    Sun, C.2    Huang, S.3    Di Nicolantonio, F.4    Salazar, R.5
  • 17
    • 70449647025 scopus 로고    scopus 로고
    • Ex vivo biomarkers: functional tools to guide targeted drug development and therapy
    • Clark DP, (2009) Ex vivo biomarkers: functional tools to guide targeted drug development and therapy. Expert Rev Mol Diagn 9: 787-794.
    • (2009) Expert Rev Mol Diagn , vol.9 , pp. 787-794
    • Clark, D.P.1
  • 19
    • 77954376912 scopus 로고    scopus 로고
    • RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models
    • Yang H, Higgins B, Kolinsky K, Packman K, Go Z, et al. (2010) RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models. Cancer Res 70: 5518-5527.
    • (2010) Cancer Res , vol.70 , pp. 5518-5527
    • Yang, H.1    Higgins, B.2    Kolinsky, K.3    Packman, K.4    Go, Z.5
  • 20
    • 77949732073 scopus 로고    scopus 로고
    • RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
    • Poulikakos PI, Zhang C, Bollag G, Shokat KM, Rosen N, (2010) RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature 464: 427-430.
    • (2010) Nature , vol.464 , pp. 427-430
    • Poulikakos, P.I.1    Zhang, C.2    Bollag, G.3    Shokat, K.M.4    Rosen, N.5
  • 21
    • 77949685981 scopus 로고    scopus 로고
    • RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
    • Hatzivassiliou G, Song K, Yen I, Brandhuber BJ, Anderson DJ, et al. (2010) RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature 464: 431-435.
    • (2010) Nature , vol.464 , pp. 431-435
    • Hatzivassiliou, G.1    Song, K.2    Yen, I.3    Brandhuber, B.J.4    Anderson, D.J.5
  • 22
    • 74849109743 scopus 로고    scopus 로고
    • Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
    • Heidorn SJ, Milagre C, Whittaker S, Nourry A, Niculescu-Duvas I, et al. (2010) Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. Cell 140: 209-221.
    • (2010) Cell , vol.140 , pp. 209-221
    • Heidorn, S.J.1    Milagre, C.2    Whittaker, S.3    Nourry, A.4    Niculescu-Duvas, I.5
  • 23
    • 78751648455 scopus 로고    scopus 로고
    • Hyperactivation of MEK-ERK1/2 signaling and resistance to apoptosis induced by the oncogenic B-RAF inhibitor, PLX4720, in mutant N-RAS melanoma cells
    • Kaplan FM, Shao Y, Mayberry MM, Aplin AE, (2011) Hyperactivation of MEK-ERK1/2 signaling and resistance to apoptosis induced by the oncogenic B-RAF inhibitor, PLX4720, in mutant N-RAS melanoma cells. Oncogene 30: 366-371.
    • (2011) Oncogene , vol.30 , pp. 366-371
    • Kaplan, F.M.1    Shao, Y.2    Mayberry, M.M.3    Aplin, A.E.4
  • 24
    • 77956513286 scopus 로고    scopus 로고
    • Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
    • Bollag G, Hirth P, Tsai J, Zhang J, Ibrahim PN, et al. (2010) Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature 467: 596-599.
    • (2010) Nature , vol.467 , pp. 596-599
    • Bollag, G.1    Hirth, P.2    Tsai, J.3    Zhang, J.4    Ibrahim, P.N.5
  • 26
    • 73349120959 scopus 로고    scopus 로고
    • Seize the opportunity: underutilization of fine-needle aspiration biopsy to inform targeted cancer therapy decisions
    • Clark DP, (2009) Seize the opportunity: underutilization of fine-needle aspiration biopsy to inform targeted cancer therapy decisions. Cancer Cytopathol 117: 289-297.
    • (2009) Cancer Cytopathol , vol.117 , pp. 289-297
    • Clark, D.P.1
  • 27
    • 79959795786 scopus 로고    scopus 로고
    • Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
    • Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, et al. (2011) Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation. N Engl J Med 364: 2507-2516.
    • (2011) N Engl J Med , vol.364 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3    Haanen, J.B.4    Ascierto, P.5
  • 28
    • 84863116743 scopus 로고    scopus 로고
    • Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib
    • Sosman JA, Kim KB, Schuchter L, Gonzalez R, Pavlick AC, et al. (2012) Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib. N Engl J Med 366: 707-714.
    • (2012) N Engl J Med , vol.366 , pp. 707-714
    • Sosman, J.A.1    Kim, K.B.2    Schuchter, L.3    Gonzalez, R.4    Pavlick, A.C.5
  • 29
    • 84863673204 scopus 로고    scopus 로고
    • Improved survival with MEK inhibition in BRAF-mutated melanoma
    • Flaherty KT, Robert C, Hersey P, Nathan P, Garbe C, et al. (2012) Improved survival with MEK inhibition in BRAF-mutated melanoma. N Engl J Med 367: 107-114.
    • (2012) N Engl J Med , vol.367 , pp. 107-114
    • Flaherty, K.T.1    Robert, C.2    Hersey, P.3    Nathan, P.4    Garbe, C.5
  • 30
    • 84856009717 scopus 로고    scopus 로고
    • Phase II, open-label, randomized trial of the MEK1/2 inhibitor selumetinib as monotherapy versus temozolomide in patients with advanced melanoma
    • Kirkwood JM, Bastholt L, Robert C, Sosman J, Larkin J, et al. (2012) Phase II, open-label, randomized trial of the MEK1/2 inhibitor selumetinib as monotherapy versus temozolomide in patients with advanced melanoma. Clin Cancer Res 18: 555-567.
    • (2012) Clin Cancer Res , vol.18 , pp. 555-567
    • Kirkwood, J.M.1    Bastholt, L.2    Robert, C.3    Sosman, J.4    Larkin, J.5
  • 31
    • 84864285704 scopus 로고    scopus 로고
    • Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial
    • Hauschild A, Grob JJ, Demidov LV, Jouary T, Gutzmer R, et al. (2012) Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet 380: 358-365.
    • (2012) Lancet , vol.380 , pp. 358-365
    • Hauschild, A.1    Grob, J.J.2    Demidov, L.V.3    Jouary, T.4    Gutzmer, R.5
  • 32
    • 79953325104 scopus 로고    scopus 로고
    • PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression
    • Paraiso KH, Xiang Y, Rebecca VW, Abel EV, Chen YA, et al. (2011) PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression. Cancer Res 71: 2750-2760.
    • (2011) Cancer Res , vol.71 , pp. 2750-2760
    • Paraiso, K.H.1    Xiang, Y.2    Rebecca, V.W.3    Abel, E.V.4    Chen, Y.A.5
  • 33
    • 79960946383 scopus 로고    scopus 로고
    • Combinatorial treatments that overcome PDGFRbeta-driven resistance of melanoma cells to V600EB-RAF inhibition
    • Shi H, Kong X, Ribas A, Lo RS, (2011) Combinatorial treatments that overcome PDGFRbeta-driven resistance of melanoma cells to V600EB-RAF inhibition. Cancer Res 71: 5067-5074.
    • (2011) Cancer Res , vol.71 , pp. 5067-5074
    • Shi, H.1    Kong, X.2    Ribas, A.3    Lo, R.S.4
  • 34
    • 84862732834 scopus 로고    scopus 로고
    • Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations
    • Greger JG, Eastman SD, Zhang V, Bleam MR, Hughes AM, et al. (2012) Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations. Mol Cancer Ther 11: 909-920.
    • (2012) Mol Cancer Ther , vol.11 , pp. 909-920
    • Greger, J.G.1    Eastman, S.D.2    Zhang, V.3    Bleam, M.R.4    Hughes, A.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.