Anti-infective therapy of peri-implantitis with adjunctive local drug delivery or photodynamic therapy: Six-month outcomes of a prospective randomized clinical trial

Clinical Oral Implants Research

Volumn 24, Issue 1, 2013, Pages 104-110

  Schär, Dorothee ^a   Ramseier, Christoph A ^a   Eick, Sigrun ^a   Arweiler, Nicole B ^b   Sculean, Anton ^a   Salvi, Giovanni E ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Dental implants; Laser; Local antibiotics; Local drug delivery; Peri implantitis; Photodynamic therapy; Surface decontamination

Indexed keywords

ANTIINFECTIVE AGENT; MICROSPHERE; MINOCYCLINE;

ADULT; AGED; ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEBRIDEMENT; FEMALE; HUMAN; MALE; METHODOLOGY; MIDDLE AGED; PERIIMPLANTITIS; PERIODONTICS; PHOTOCHEMOTHERAPY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TOOTH PLAQUE; TREATMENT OUTCOME;

ADULT; AGED; ANTI-BACTERIAL AGENTS; DEBRIDEMENT; DENTAL PLAQUE INDEX; FEMALE; HUMANS; MALE; MICROSPHERES; MIDDLE AGED; MINOCYCLINE; PERI-IMPLANTITIS; PERIODONTAL INDEX; PHOTOCHEMOTHERAPY; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84871707769     PISSN: 09057161     EISSN: 16000501     Source Type: Journal    
DOI: 10.1111/j.1600-0501.2012.02494.x     Document Type: Article

References (51)

1. Albrektsson, T. & Isidor, F. (1994) Consesus report: implant therapy. In: Lang, N.P. & Karring, T., eds. Proceedings of the First European Workshop on Periodontology, 365-369. Berlin: Quintessenz.
2. Alcoforado, G.A., Rams, T.E., Feik, D. & Slots, J. (1991) Microbial aspects of failing osseointegrated dental implants in humans. Journal de Parodontologie 10: 11-18.
3. Andersen, R., Loebel, N., Hammond, D. & Wilson, M. (2007) Treatment of periodontal disease by photodisinfection compared to scaling and root planing. Journal of Clinical Dentistry 18: 34-38.
4. Augthun, M. & Conrads, G. (1997) Microbial findings of deep peri-implant bone defects. International Journal of Oral & Maxillofacial Implants 12: 106-112.
5. Azarpazhooh, A., Shah, P.S., Tenenbaum, H.C. & Goldberg, M.B. (2011) The effect of photodynamic therapy for periodontitis: a systematic review and meta-analysis. Journal of Periodontology 81: 4-14.
6. Becker, W., Becker, B.E., Newman, M.G. & Nyman, S. (1990) Clinical and microbiologic findings that may contribute to dental implant failure. International Journal of Oral & Maxillofacial Implants 5: 31-38.
7. Braun, A., Dehn, C., Krause, F. & Jepsen, S. (2008) Short-term clinical effects of adjunctive antimicrobial photodynamic therapy in periodontal treatment: a randomized clinical trial. Journal of Clinical Periodontology 35: 877-884.
8. Büchter, A., Meyer, U., Kruse-Losler, B., Joos, U. & Kleinheinz, J. (2004) Sustained release of doxycycline for the treatment of peri-implantitis: randomised controlled trial. British Journal of Oral and Maxillofacial Surgery 42: 439-444.
9. Chondros, P., Nikolidakis, D., Christodoulides, N., Rossler, R., Gutknecht, N. & Sculean, A. (2009) Photodynamic therapy as adjunct to non-surgical periodontal treatment in patients on periodontal maintenance: a randomized controlled clinical trial. Lasers in Medical Science 24: 681-688.
10. Christodoulides, N., Nikolidakis, D., Chondros, P., Becker, J., Schwarz, F., Rossler, R. & Sculean, A. (2008) Photodynamic therapy as an adjunct to non-surgical periodontal treatment: a randomized, controlled clinical trial. Journal of Periodontology 79: 1638-1644.
11. De Boever, A.L. & De Boever, J.A. (2006) Early colonization of non-submerged dental implants in patients with a history of advanced aggressive periodontitis. Clinical Oral Implants Research 17: 8-17.
12. Dobson, J. & Wilson, M. (1992) Sensitization of oral bacteria in biofilms to killing by light from a low-power laser. Archives of Oral Biology 37: 883-887.
13. Fürst, M.M., Salvi, G.E., Lang, N.P. & Persson, G.R. (2007) Bacterial colonization immediately after installation on oral titanium implants. Clinical Oral Implants Research 18: 501-508.
14. Ge, L., Shu, R., Li, Y., Li, C., Luo, L., Song, Z., Xie, Y. & Liu, D. (2011) Adjunctive effect of photodynamic therapy to scaling and root planing in the treatment of chronic periodontitis. Photomedicine and Laser Surgery 29: 33-37.
15. Haas, R., Dörtbudak, O., Mensdorff-Pouilly, N. & Mailath, G. (1997) Elimination of bacteria on different implant surfaces through photosensitization and soft laser. An in vitro study. Clinical Oral Implants Research 8: 249-254.
16. Hardt, C.R., Gröndahl, K., Lekholm, U. & Wennström, J.L. (2002) Outcome of implant therapy in relation to experienced loss of periodontal bone support: a retrospective 5-year study. Clinical Oral Implants Research 13: 488-494.
17. Hayek, R.R., Araujo, N.S., Gioso, M.A., Ferreira, J., Baptista-Sobrinho, C.A., Yamada, A.M. & Ribeiro, M.S. (2005) Comparative study between the effects of photodynamic therapy and conventional therapy on microbial reduction in ligature-induced peri-implantitis in dogs. Journal of Periodontology 76: 1275-1281.
18. Herrera, D. (2011) Insufficient evidence for photodynamic therapy use in periodontitis. Evidence Based Dentistry 12: 46.
19. ® dental implant system. Clinical Oral Implants Research 14: 329-339.
20. Karring, E.S., Stavropoulos, A., Ellegaard, B. & Karring, T. (2005) Treatment of peri-implantitis by the Vector system. Clinical Oral Implants Research 16: 288-293.
21. Konopka, K. & Goslinski, T. (2007) Photodynamic therapy in dentistry. Journal of Dental Research 86: 694-707.
22. Lang, N.P., Joss, A., Orsanic, T., Gusberti, F.A. & Siegrist, B.E. (1986) Bleeding on probing. A predictor for the progression of periodontal disease? Journal of Clinical Periodontology 13: 590-596.
23. Leonhardt, A., Renvert, S. & Dahlen, G. (1999) Microbial findings at failing implants. Clinical Oral Implants Research 10: 339-345.
24. Mombelli, A., Buser, D. & Lang, N.P. (1988) Colonization of osseointegrated titanium implants in edentulous patients. Early results. Oral Microbiology and Immunology 3: 113-120.
25. Mombelli, A., Feloutzis, A., Brägger, U. & Lang, N.P. (2001) Treatment of peri-implantitis by local delivery of tetracycline. Clinical, microbiological and radiological results. Clinical Oral Implants Research 12: 287-294.
26. Mombelli, A. & Lang, N.P. (1992) Antimicrobial treatment of peri-implant infections. Clinical Oral Implants Research 3: 162-168.
27. Mombelli, A. & Lang, N.P. (1998) The diagnosis and treatment of peri-implantitis. Periodontology 2000 17: 63-76.
28. Mombelli, A., Marxer, M., Gaberthüel, T., Grunder, U. & Lang, N.P. (1995) The microbiota of osseointegrated implants in patients with a history of periodontal disease. Journal of Clinical Periodontology 22: 124-130.
29. Mombelli, A., van Oosten, M.A., Schürch, E. Jr & Lang, N.P. (1987) The microbiota associated with successful or failing osseointegrated titanium implants. Oral Microbiology and Immunology 2: 145-151.
30. ®) in the treatment of peri-implantitis. I: microbiological outcomes. Clinical Oral Implants Research 17: 386-393.
31. Pontoriero, R., Tonelli, M.P., Carnevale, G., Mombelli, A., Nyman, S.R. & Lang, N.P. (1994) Experimentally induced peri-implant mucositis. A clinical study in humans. Clinical Oral Implants Research 5: 254-259.
32. Quirynen, M., De Soete, M. & van Steenberghe, D. (2002) Infectious risks for oral implants: a review of the literature. Clinical Oral Implants Research 13: 1-19.
33. Quirynen, M., Papaioannou, W. & van Steenberghe, D. (1996) Intraoral transmission and the colonization of oral hard surfaces. Journal of Periodontology 67: 986-993.
34. Quirynen, M., Vogels, R., Peeters, W., van Steenberghe, D., Naert, I. & Haffajee, A. (2006) Dynamics of initial subgingival colonization of 'pristine' peri-implant pockets. Clinical Oral Implants Research 17: 25-37.
35. Rams, T.E., Roberts, T.W., Feik, D., Molzan, A.K. & Slots, J. (1991) Clinical and microbiological findings on newly inserted hydroxyapatite-coated and pure titanium human dental implants. Clinical Oral Implants Research 2: 121-127.
36. Renvert, S., Lessem, J., Dahlen, G., Lindahl, C. & Svensson, M. (2006) Topical minocycline microspheres versus topical chlorhexidine gel as an adjunct to mechanical debridement of incipient peri-implant infections: a randomized clinical trial. Journal of Clinical Periodontology 33: 362-369.
37. Renvert, S., Lessem, J., Dahlen, G., Renvert, H. & Lindahl, C. (2008) Mechanical and repeated antimicrobial therapy using a local drug delivery system in the treatment of peri-implantitis: a randomized clinical trial. Journal of Periodontology 79: 836-844.
38. Renvert, S., Lessem, J., Lindahl, C. & Svensson, M. (2004) Treatment of incipient peri-implant infections using topical minocycline microspheres versus topical chlorhexidine gel as an adjunct to mechanical debridement. Journal of the International Academy of Periodontology 6: 154-159.
39. Renvert, S., Samuelsson, E., Lindahl, C. & Persson, G.R. (2009) Mechanical non-surgical treatment of peri-implantitis: a double-blind randomized longitudinal clinical study. I: clinical results. Journal of Clinical Periodontology 36: 604-609.
40. Roccuzzo, M., Bonino, F., Aglietta, M. & Dalmasso, P. (2012) Ten-year results of a three arms prospective cohort study on implants in periodontally compromised patients. Part 2: clinical results. Clinical Oral Implants Research 23: 389-395.
41. Roccuzzo, M., De Angelis, N., Bonino, L. & Aglietta, M. (2010) Ten-year results of a three arms prospective cohort study on implants in periodontally compromised patients. Part 1: implant loss and radiographic bone loss. Clinical Oral Implants Research 21: 490-496.
42. Sahm, N., Becker, J., Santel, T. & Schwarz, F. (2011) Non-surgical treatment of peri-implantitis using an air-abrasive device or mechanical debridement and local application of chlorhexidine: a prospective, randomized, controlled clinical study. Journal of Clinical Periodontology 38: 872-878.
43. Salcetti, J.M., Moriarty, J.D., Cooper, L.F., Smith, F.W., Collins, J.G., Socransky, S.S. & Offenbacher, S. (1997) The clinical, microbial, and host response characteristics of the failing implant. International Journal of Oral & Maxillofacial Implants 12: 32-42.
44. Salvi, G.E., Aglietta, M., Eick, S., Sculean, A., Lang, N.P. & Ramseier, C.A. (2012) Reversibility of experimental peri-implant mucositis compared with experimental gingivitis in humans. Clinical Oral Implants Research 23: 182-190.
45. Salvi, G.E., Fürst, M.M., Lang, N.P. & Persson, G.R. (2008) One-year bacterial colonization patterns of Staphylococcus aureus and other bacteria at implants and adjacent teeth. Clinical Oral Implants Research 19: 242-248.
46. Salvi, G.E., Persson, G.R., Heitz-Mayfield, L.J., Frei, M. & Lang, N.P. (2007) Adjunctive local antibiotic therapy in the treatment of peri-implantitis. II: clinical and radiographic outcomes. Clinical Oral Implants Research 18: 281-285.
47. Schwarz, F., Sculean, A., Rothamel, D., Schwenzer, K., Georg, T. & Becker, J. (2005) Clinical evaluation of an Er:Yag laser for nonsurgical treatment of peri-implantitis: a pilot study. Clinical Oral Implants Research 16: 44-52.
48. Shibli, J.A., Martins, M.C., Theodoro, L.H., Lotufo, R.F., Garcia, V.G. & Marcantonio, E.J. (2003) Lethal photosensitization in microbiological treatment of ligature-induced peri-implantitis: a preliminary study in dogs. Journal of Oral Sciences 45: 17-23.
49. Sumida, S., Ishihara, K., Kishi, M. & Okuda, K. (2002) Transmission of periodontal disease-associated bacteria from teeth to osseointegrated implant regions. International Journal of Oral & Maxillofacial Implants 17: 696-702.
50. van Winkelhoff, A.J., Goene, R.J., Benschop, C. & Folmer, T. (2000) Early colonization of dental implants by putative periodontal pathogens in partially edentulous patients. Clinical Oral Implants Research 11: 511-520.
51. Zablotsky, M.H., Diedrich, D.L. & Meffert, R.M. (1992) Detoxification of endotoxin-contaminated titanium and hydroxyapatite-coated surfaces utilizing various chemotherapeutic and mechanical modalities. Implant Dentistry 1: 154-158.