Molecular characterization of a respiratory syncytial virus outbreak in a hematology unit in Heidelberg, Germany

Journal of Clinical Microbiology

Volumn 51, Issue 1, 2013, Pages 155-162

  Geis, Steffen ^a   Prifert, Christiane ^b   Weissbrich, Benedikt ^b   Lehners, Nicola ^a   Egerer, Gerlinde ^a   Eisenbach, Christoph ^a   Buchholz, Udo ^c   Aichinger, Elisabeth ^c,d   Dreger, Peter ^a   Neben, Kai ^a   Burkhardt, Ulrich ^a   Ho, Anthony D ^a   Kräusslich, Hans Georg ^a   Heeg, Klaus ^a   Schnitzler, Paul ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c ROBERT KOCH INSTITUTE   (Germany)

^d Wiederholdstr 15   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHILD; EPIDEMIC; GENE CLUSTER; GENOTYPE; GERMANY; HOSPITAL INFECTION; HUMAN; IMMUNOCOMPROMISED PATIENT; INFECTION CONTROL; LUNG LAVAGE; MAJOR CLINICAL STUDY; NONHUMAN; NOSE SMEAR; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RESPIRATORY SYNCYTIAL PNEUMOVIRUS TYPE A; RESPIRATORY SYNCYTIAL PNEUMOVIRUS TYPE B; RESPIRATORY SYNCYTIAL VIRUS INFECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; STRAIN DIFFERENCE; STRAIN IDENTIFICATION; THROAT CULTURE; VIRUS GENE; VIRUS SHEDDING; VIRUS STRAIN; VIRUS TRANSMISSION; WARD;

CHILD; CHILD, PRESCHOOL; CLUSTER ANALYSIS; CROSS INFECTION; DISEASE OUTBREAKS; DNA, VIRAL; FEMALE; GENOTYPE; GERMANY; HUMANS; MALE; MIDDLE AGED; MOLECULAR EPIDEMIOLOGY; MOLECULAR SEQUENCE DATA; PHYLOGENY; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; SEQUENCE ANALYSIS, DNA; VIRUS SHEDDING;

RESPIRATORY SYNCYTIAL VIRUS; RICE STRIPE VIRUS;

EID: 84871691817     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.02151-12     Document Type: Article

References (36)

1. Hall CB. 2001. Respiratory syncytial virus and parainfluenza virus. N. Engl. J. Med. 344:1917-1928. (Pubitemid 32553362)
2. Hall CB, Douglas RG, Jr. 1981. Modes of transmission of respiratory syncytial virus. J. Pediatr. 99:100-103. (Pubitemid 11046430)
3. Garcia O, Martin M, Dopazo J, Arbiza J, Frabasile S, Russi J, Hortal M, Perez-Brena P, Martinez I, Garcia-Barreno B. 1994. Evolutionary pattern of human respiratory syncytial virus (subgroup A): cocirculating lineages and correlation of genetic and antigenic changes in the G glycoprotein. J. Virol. 68:5448-5459. (Pubitemid 24258557)
4. Sullender WM, Mufson MA, Prince GA, Anderson LJ, Wertz GW. 1998. Antigenic and genetic diversity among the attachment proteins of group A respiratory syncytial viruses that have caused repeat infections in children. J. Infect. Dis. 178:925-932. (Pubitemid 28452181)
5. Hall CB, Walsh EE, Long CE, Schnabel KC. 1991. Immunity to and frequency of reinfection with respiratory syncytial virus. J. Infect. Dis. 163:693-698.
6. Terletskaia-Ladwig E, Enders G, Schalasta G, Enders M. 2005. Defining the timing of respiratory syncytial virus (RSV) outbreaks: an epidemiological study. BMC Infect. Dis. 5:20.
7. Avetisyan G, Mattsson J, Sparrelid E, Ljungman P. 2009. Respiratory syncytial virus infection in recipients of allogeneic stem-cell transplantation: a retrospective study of the incidence, clinical features, and outcome. Transplantation 88:1222-1226.
8. Chemaly RF, Ghosh S, Bodey GP, Rohatgi N, Safdar A, Keating MJ, Champlin RE, Aguilera EA, Tarrand JJ, Raad II. 2006. Respiratory viral infections in adults with hematologic malignancies and human stem cell transplantation recipients: a retrospective study at a major cancer center. Medicine (Baltimore) 85:278-287. (Pubitemid 44401460)
9. McCarthy AJ, Kingman HM, Kelly C, Taylor GS, Caul EO, Grier D, Moppett J, Foot AB, Cornish JM, Oakhill A, Steward CG, Pamphilon DH, Marks DI. 1999. The outcome of 26 patients with respiratory syncytial virus infection following allogeneic stem cell transplantation. Bone Marrow Transplant. 24:1315-1322. (Pubitemid 30052788)
10. Shah JN, Chemaly RF. 2011. Management of RSV infections in adult recipients of hematopoietic stem cell transplantation. Blood 117:2755-2763.
11. Torres HA, Aguilera EA, Mattiuzzi GN, Cabanillas ME, Rohatgi N, Sepulveda CA, Kantarjian HM, Jiang Y, Safdar A, Raad II, Chemaly RF. 2007. Characteristics and outcome of respiratory syncytial virus infection in patients with leukemia. Haematologicaae 92:1216-1223. (Pubitemid 350144180)
12. Abdallah A, Rowland KE, Schepetiuk SK, To LB, Bardy P. 2003. An outbreak of respiratory syncytial virus infection in a bone marrow transplant unit: effect on engraftment and outcome of pneumonia without specific antiviral treatment. Bone Marrow Transplant. 32:195-203. (Pubitemid 36903444)
13. Harrington RD, Hooton TM, Hackman RC, Storch GA, Osborne B, Gleaves CA, Benson A, Meyers JD. 1992. An outbreak of respiratory syncytial virus in a bone marrow transplant center. J. Infect. Dis. 165:987-993.
14. Jalal H, Bibby DF, Bennett J, Sampson RE, Brink NS, MacKinnon S, Tedder RS, Ward KN. 2007. Molecular investigations of an outbreak of parainfluenza virus type 3 and respiratory syncytial virus infections in a hematology unit. J. Clin. Microbiol. 45:1690-1696. (Pubitemid 46933893)
15. Mendes ET, Ramos J, Peixoto D, Dulley F, Alves T, Vilas Boas LS, Batista MV, da Silva DP, Levin AS, Shikanai-Yasuda MA, Costa SF. 2012. An outbreak of respiratory syncytial virus infection in hematopoietic stem cell transplantation outpatients: good outcome without specific antiviral treatment. Transplant Infect. Dis. [Epub ahead of print.] doi:10.1111/j.1399-3062.2012.00764.x.
16. Whimbey E, Champlin RE, Couch RB, Englund JA, Goodrich JM, Raad I, Przepiorka D, Lewis VA, Mirza N, Yousuf H, Tarrand JJ, Bodey GP. 1996. Community respiratory virus infections among hospitalized adult bone marrow transplant recipients. Clin. Infect. Dis. 22:778-782. (Pubitemid 26255593)
17. Storch GA, Anderson LJ, Park CS, Tsou C, Dohner DE. 1991. Antigenic and genomic diversity within group A respiratory syncytial virus. J. Infect. Dis. 163:858-861.
18. Peret TC, Hall CB, Schnabel KC, Golub JA, Anderson LJ. 1998. Circulation patterns of genetically distinct group A and B strains of human respiratory syncytial virus in a community. J. Gen. Virol. 79(Pt 9):2221-2229. (Pubitemid 28423418)
19. Trento A, Galiano M, Videla C, Carballal G, Garcia-Barreno B, Melero JA, Palomo C. 2003. Major changes in the G protein of human respiratory syncytial virus isolates introduced by a duplication of 60 nucleotides. J. Gen. Virol. 84:3115-3120. (Pubitemid 37336796)
20. Cane PA, Pringle CR. 1995. Evolution of subgroup A respiratory syncytial virus: evidence for progressive accumulation of amino acid changes in the attachment protein. J. Virol. 69:2918-2925.
21. Reiche J, Schweiger B. 2009. Genetic variability of group A human respiratory syncytial virus strains circulating in Germany from 1998 to 2007. J. Clin. Microbiol. 47:1800-1810.
22. Tamura K, Nei M. 1993. Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. Mol. Biol. Evol. 10:512-526. (Pubitemid 23157236)
23. Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S. 2011. MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol. Biol. Evol. 28:2731-2739.
24. Taylor GS, Vipond IB, Caul EO. 2001. Molecular epidemiology of outbreak of respiratory syncytial virus within bone marrow transplantation unit. J. Clin. Microbiol. 39:801-803. (Pubitemid 32150868)
25. Mazzulli T, Peret TC, McGeer A, Cann D, MacDonald KS, Chua R, Erdman DD, Anderson LJ. 1999. Molecular characterization of a nosocomial outbreak of human respiratory syncytial virus on an adult leukemia/lymphoma ward. J. Infect. Dis. 180:1686-1689. (Pubitemid 29506475)
26. Visser A, Delport S, Venter M. 2008. Molecular epidemiological analysis of a nosocomial outbreak of respiratory syncytial virus associated pneumonia in a kangaroo mother care unit in South Africa. J. Med. Virol. 80:724-732. (Pubitemid 351358573)
27. McCann S, Byrne JL, Rovira M, Shaw P, Ribaud P, Sica S, Volin L, Olavarria E, Mackinnon S, Trabasso P, VanLint MT, Ljungman P, Ward K, Browne P, Gratwohl A, Widmer AF, Cordonnier C. 2004. Outbreaks of infectious diseases in stem cell transplant units: a silent cause of death for patients and transplant programmes. Bone Marrow Transplant. 33:519-529. (Pubitemid 38425783)
28. Hirsch H, Boeckh M, Einsele H, Martino R, Ward KN. 2012. Community-acquired respiratory virus (CARV) infections other than influenza and adenovirus: respiratory syncytial-, human metapneumo-, parainfluenza-, rhino-, and coronavirus. 4th European Conference on Infections in Leukemia. LeukemiaNet, Juan-les-Pins, France. http://www.leukemia-net.org/content/treat-research/ supportive-care/standards-sop-and-recommendations/index-eng.html.
29. Tomblyn M, Chiller T, Einsele H, Gress R, Sepkowitz K, Storek J, Wingard JR, Young JA, Boeckh MJ. 2009. Guidelines for preventing infectious complications among hematopoietic cell transplantation recipients: a global perspective. Biol. Blood Marrow Transplant. 15:1143-1238.
30. Taylor CE, Morrow S, Scott M, Young B, Toms GL. 1989. Comparative virulence of respiratory syncytial virus subgroups A and B. Lancet i:777-778. (Pubitemid 19093499)
31. Hall CB, Walsh EE, Schnabel KC, Long CE, McConnochie KM, Hildreth SW, Anderson LJ. 1990. Occurrence of groups A and B of respiratory syncytial virus over 15 years: associated epidemiologic and clinical characteristics in hospitalized and ambulatory children. J. Infect. Dis. 162:1283-1290.
32. Brandenburg AH, van Beek R, Moll HA, Osterhaus AD, Claas EC. 2000. G protein variation in respiratory syncytial virus group A does not correlate with clinical severity. J. Clin. Microbiol. 38:3849-3852.
33. Martinello RA, Chen MD, Weibel C, Kahn JS. 2002. Correlation between respiratory syncytial virus genotype and severity of illness. J. Infect. Dis. 186:839-842. (Pubitemid 35013438)
34. Falsey AR, Walsh EE. 2000. Respiratory syncytial virus infection in adults. Clin. Microbiol. Rev. 13:371-384. (Pubitemid 30452612)
35. Khanna N, Widmer AF, Decker M, Steffen I, Halter J, Heim D, Weisser M, Gratwohl A, Fluckiger U, Hirsch HH. 2008. Respiratory syncytial virus infection in patients with hematological diseases: single-center study and review of the literature. Clin. Infect. Dis. 46:402-412. (Pubitemid 351263523)
36. Gooskens J, Jonges M, Claas EC, Meijer A, Kroes AC. 2009. Prolonged influenza virus infection during lymphocytopenia and frequent detection of drug-resistant viruses. J. Infect. Dis. 199:1435-1441.