Synthesis, antimicrobial and anticancer activities of some new N-methylsulphonyl and N-benzenesulphonyl-3-indolyl heterocycles. 1st Cancer Update.

Arabian Journal of Chemistry

Volumn 6, Issue 1, 2013, Pages 67-78

  El Sawy, Eslam Reda ^a   Mandour, Adel Hamed ^a   El Hallouty, Salwa M ^a   Shaker, Kamel Hussein ^b   Abo Salem, Heba Mohamed ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b KING KHALID UNIVERSITY   (Saudi Arabia)

Author keywords

Anticancer activity; Antimicrobial activity; Heterocycles; Indole

Indexed keywords

ACTIVE COMPOUNDS; ANTI-MICROBIAL ACTIVITY; ANTICANCER ACTIVITIES; BASE-CATALYZED REACTION; CELL LINES; CYCLOHEXANONE DERIVATIVES; DOXORUBICIN; ETHYLACETOACETATE; HETEROCYCLES; HUMAN BREAST CANCER; HUMAN COLON CANCER; HUMAN LIVER; HYDRAZINE HYDRATE; HYDROXYL AMINES; IN-VITRO; INDAZOLE; INDOLE; ISOXAZOLES; PYRAZOLE DERIVATIVES; PYRIMIDINE DERIVATIVES; SALMONELLA TYPHIMURIUM; THIONES;

CELL CULTURE; DISEASES; HYDRATES; HYDRATION; SALMONELLA; SYNTHESIS (CHEMICAL); THIOUREAS; UREA;

HYDRAZINE;

EID: 84871684846     PISSN: 18785352     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arabjc.2012.04.003     Document Type: Article

References (15)

1. Abdel-Rahman1 A.A.H., Abdel-Megied A.E.S., Hawata M.A.M., Kasem E.R., Shabaan M.T. Synthesis and antimicrobial evaluation of some chalcones and their derived pyrazoles, pyrazolines, isoxazolines, and 5,6-dihydropyrimidine-2-(1H)-thiones. Monatsh. Chemie. 2007, 138:889-897.
2. Aitmambetov A., Menlimuratova Z. Interaction of synthetic analogues of natural chalcones and flavones with guanidine. Russ. J. Bioorg. Chem. 2003, 29:175-176.
3. Bauer A.W., Kirby W.W.M., Sherris J.C., Turck M. Antibiotic susceptibility testing by a standardized single disc method. Am. J. Clin. Pathol. 1966, 36:493-496.
4. El Shehry M.F., Swellem R.H., Abu-Bakr Sh.M.b., El-Telbani E.M. Synthesis and molluscicidal evaluation of some new pyrazole, isoxazole, pyridine, pyrimidine, 1,4-thiazine and 1,3,4-thiadiazine derivatives incorporating benzofuran moiety. Eur. J. Med. Chem. 2010, 45:4783-4787.
5. El-Sawy E.R., Mandour A.H., Mahmoud N.A., Mustafa M. Synthesis, antimicrobial and anti-inflammatory activities of some new N-substituted sulphonyl indole-3-heterocyclic derivatives. Egypt. J. Chem. 2009, 52:541-553.
6. El-Sawy E.R., Bassyouni F.A., Abu-Bakr S.H., Rady H.M., Abdlla M.M. Synthesis and biological activity of some new 1-benzyl and 1-benzoyl 3- heterocyclic indole derivatives. Acta Pharm. 2010, 60:55-71.
7. Flefel E.E., Salama M.A., E-Shahat M., El-Hashash M.A., El-Farargy A.F. A novel synthesis of some pyrimidine and thiazolopyrimidine derivatives for anticancer evaluation. Phosphorus Sulfur Silicon 2007, 182:1739-1756.
8. George S., Waran M.P., Chakraborty A., Ravi T.K. Synthesis and evaluation of the biological activities of some 3-[5-(6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl]-imino-1,3-di-hydro-2H-indol-2-one derivatives. Acta Pharm. 2008, 58:119-129.
9. Mandour A.H., El-Sawy E.R., Ebid M.S., El-Sayed Z.G. Synthesis of 1-benzyl and 1-benzoyl-3-indole derivatives with expected antimicrobial activity. Egypt. J. Chem. 2007, 50:555-568.
10. Mandour A.H., El-Sawy E.R., Shaker K.H., Mustafa M.A. Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indole. Acta Pharm. 2010, 60:73-88.
11. Mndzhoyan A.L., Papayan G.L., Zhuruli L.D., Karagezyan S.G.L., Galstyan S., Sarafyan V.G. Synthesis and biological study of hydrazinohydrazones of indole aldehydes and ketons series. Arm. Khim. Zh. (USSR) 1969, 22:707-713.
12. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Meth. 1983, 65:55-63.
13. Ngameni B., Watchueng J., Boyom F.F., Keumedjio F., Ngadjui B.T., Gut J., Abegaz B.M., Rosenthal P.J. Antimalarial prenylated chalcones from the twigs of Dorstenia barteri var. subtriangularis. ARKIVOC 2007, xiii:116-123.
14. Okwu D.E., Ukanwa N. Isolation and characterization of flavonoids chalcones and anthocynidines from bridelia ferruginea benth. Der Chem. Sinica 2010, 1:21-28.
15. Sreevidya V.T., Narayana B., Yathirajan H.S. Synthesis and characterization of some chalcones and their cyclohexenone derivatives. Cent. Eur. J. Chem. 2010, 8:174-181.