A neurobehavioral analysis of the prevention of visual impairment in the DBA/2J mouse model of glaucoma

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 9, 2012, Pages 5956-5966

  Wong, Aimée A ^a   Brown, Richard E ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

TIMOLOL MALEATE; WHEAT GERM AGGLUTININ HORSERADISH PEROXIDASE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIAGNOSTIC AGENT; EYE DROPS; TIMOLOL;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CONTROLLED STUDY; DBA 2 MOUSE; FEMALE; FORCED SWIMMING TEST; GLAUCOMA; HISTOLOGY; INTRAOCULAR PRESSURE; LIMIT OF QUANTITATION; LONGITUDINAL STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUPERIOR COLLICULUS; TASK PERFORMANCE; VISUAL ACUITY; VISUAL IMPAIRMENT; AGING; ANIMAL; DBA MOUSE; DISEASE MODEL; DRUG EFFECT; OPEN ANGLE GLAUCOMA; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RETINA GANGLION CELL; TOPICAL DRUG ADMINISTRATION; TREATMENT OUTCOME; VISION; VISUAL DISORDER;

ADMINISTRATION, TOPICAL; ADRENERGIC BETA-ANTAGONISTS; AGING; ANIMALS; BEHAVIOR, ANIMAL; CELL COUNT; DISEASE MODELS, ANIMAL; FEMALE; GLAUCOMA, OPEN-ANGLE; INTRAOCULAR PRESSURE; MALE; MICE; MICE, INBRED DBA; OPHTHALMIC SOLUTIONS; RETINAL GANGLION CELLS; SUPERIOR COLLICULI; TIMOLOL; TREATMENT OUTCOME; VISION DISORDERS; VISUAL PERCEPTION; WHEAT GERM AGGLUTININ-HORSERADISH PEROXIDASE CONJUGATE;

EID: 84871677404     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-10020     Document Type: Article

References (56)

1. Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006;90:262-267.
2. Quigley HA. Open-angle glaucoma. N Engl J Med. 1993;328: 1097-1106.
3. Quigley HA. Neuronal death in glaucoma. Prog Retin Eye Res. 2004;18:39-57.
4. Ritch R. Pigment dispersion syndrome. Am J Ophthalmol. 1998;126:442-445.
5. Sowka J. Pigmentary dispersion syndrome and pigmentary glaucoma. Optometry. 2004;75:115-122.
6. Leske MC, Podgor MJ. Intraocular pressure, cardiovascular risk variables, and visual field defects. Am J Epidemiol. 1983;118: 280-287.
7. Obstbaum SA, Cioffi GA, Krieglstein GK, et al. Gold standard medical therapy for glaucoma: defining the criteria identifying measures for an evidence-based analysis. Clin Ther. 2004;12: 2102-2120.
8. van der Valk R, Webers CAB, Lumley T, Hendrikse F, Prins MH, Schouten JSAG. A network meta-analysis combined direct and indirect comparisons between glaucoma drugs to rank effectiveness in lowering intraocular pressure. J Clin Epidemiol. 2009;62:1279-1283.
9. Wallace LM, Alward MD. Medical management of glaucoma. N Engl J Med. 1998;18:1298-1307.
10. Anderson MG, Smith RS, Hawes NL, et al. Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice. Nat Genet. 2002;30:81-85.
11. Chang B, Smith RS, Hawes NL, et al. Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice. Nat Genet. 1999;21:405-409.
12. John SWM, Smith RS, Savinova OV, et al. Essential iris atrophy, pigment dispersion, and glaucoma in DBA/2J mice. Invest Ophthalmol Vis Sci. 1998;39:951-962.
13. Libby RT, Anderson MG, Pang I, et al. Inherited glaucoma in DBA/2J mice: pertinent disease features for studying neurodegeneration. Vis Neurosci. 2005;22:637-648.
14. Wong AA, Brown RE. Age-related changes in visual acuity, learning and memory in C57BL/6J and DBA/2J mice. Neurobiol Aging. 2007;28:1577-1593.
15. Bayer AU, Neuhardt T, May AC, et al. Retinal morphology and ERG response in the DBA/2Nnia mouse model of angle-closure glaucoma. Invest Ophthalmol Vis Sci. 2001;42:1258-1265.
16. Raymond ID, Pool AL, Vila A, Brecha NC. The Thy1-CFP DBA/ 2J mouse line with cyan fluorescent protein expression in retinal ganglion cells. Vis Neurosci. 2009;26:453-465.
17. Scholz M, Buder T, Seeber S, Adamek E, Becker C, Lutjen-Drecoll E. Dependency of intraocular pressure elevation and glaucomatous changes in DBA/2J and DBA/2J-Rj mice. Invest Ophthalmol Vis Sci. 2008;49:613-621.
18. Zhou X, Li F, Kong L, Tomita H, Li C, Cao W. Involvement of inflammation, degradation and apoptosis in a mouse model of glaucoma. J Biol Chem. 2005;280:1240-1248.
19. Moon J, Kim I, Bwon J, et al. Changes in retinal neuronal populations in the DBA/2J mouse. Cell Tissue Res. 2005;320: 51-59.
20. Schlamp CL, Li Y, Dietz JA, Janssen KT, Nickells RW. Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric. BMC Neurosci. 2006;7:66.
21. Ju W, Kim K, Angert M, et al. Memantine blocks mitochondrial OPA1 and cytochrome c release and subsequent apoptotic cell death in glaucomatous retina. Invest Ophthalmol Vis Sci. 2009;50:707-716.
22. Nagaraju M, Saleh M, Porciatti V. IOP-dependent retinal ganglion cell dysfunction in glaucomatous DBA/2J mice. Invest Ophthalmol Vis Sci. 2007;48:4573-4579.
23. Schuettauf F, Quinto K, Naskar R, Zurakowski D. Effects of anti-glaucoma medications on ganglion cell survival: the DBA/ 2J mouse model. Vision Res. 2002;42:2333-2337.
24. Zhong L, Bradley J, Schubert W, et al. Erythropoietin promotes survival of retinal ganglion cells in DBA/2J glaucoma mice. Invest Ophthalmol Vis Sci. 2007;48:1212-1218.
25. Prusky GT, West PWR, Douglas RM. Behavioral assessment of visual acuity in mice and rats. Vision Res. 2000;40:2201-2209.
26. Wong AA, Brown RE. Visual detection, pattern discrimination and visual acuity in 14 strains of mice. Gene Brain Behav. 2006;5:389-403.
27. Kontiola A. A new electromechanical method for measuring intraocular pressure. Doc Ophthamol. 1996;93:265-276.
28. Coulter JD, Sullivan MC, Ruda MA. Lectins as markers for studies of neuronal connectivity. Soc Neurosci Abstr. 1980;6: 339.
29. Fabian RH, Coulter JD. Transneuronal transport of lectins. Brain Res. 1985;344:41-48.
30. Itaya SK, Van Hoesen GW. WGA-HRP as a transneuronal marker in the visual pathways of monkey and rat. Brain Res. 1982;236:199-204.
31. Glaser JR, Glaser EM. Stereology, morphology, and mapping: the whole is greater than the sum of it parts. J Chem Neuroanat. 2000;20:115-126.
32. Gundersen HJ, Jensen EB, Kieu K, Nielsen J. The efficiency of systematic sampling in stereology-reconsidered. J Microsc. 1999;193:199-211.
33. Schmitz C, Hof PR. Design-based stereology in neuroscience. Neuroscience. 2005;130:813-831.
34. Jakobs TC, Libby RT, Ben Y, John SWM, Masland RH. Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice. J Cell Biol. 2005;171:313-325.
35. Anderson MG, Libby RT, Gould DB, Smith RS, John SWM. Highdose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucoma. Proc Natl Acad Sci U S A. 2005;102:4566-4571.
36. Crish SD, Sappington RM, Inman DM, Horner PJ, Calkins DJ. Distal axonpathy with structural persistence in glaucomatous neurodegeneration. Proc Natl Acad Sci U S A. 2010;107: 5196-5201.
37. Buckingham BP, Inman DM, Lambert W, et al. Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma. Neurobiol Dis. 2008;28:2735-2744.
38. Kanamoto T, Ue T, Yokoyama T, Souchelnytskyi N, Kiuchi Y. Proteomic study of DBA/2J mice retina: Down regulation of integrin beta7 correlated with retinal ganglion cell death. Proteomics. 2009;9:4962-4969.
39. Soto I, Oglesby E, Buckingham BP, et al. Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model. J Neurosci. 2008;28:548-561.
40. Saleh M, Nagaraju M, Porciatti V. Longitudinal evaluation of retinal ganglion cell function and IOP in the DBA/2J mouse model of glaucoma. Invest Ophthalmol Vis Sci. 2007;48:4564-4572.
41. Harwerth RS, Carter-Dawson L, Smith EL III, et al. Neural losses correlated with visual losses in clinical perimetry. Invest Ophthalmol Vis Sci. 2004;45:3152-3160.
42. Harwerth RS, Quigley HA. Visual field deficits and retinal ganglion cell losses in human glaucoma patients. Arch Ophthalmol. 2006;124:853-859.
43. Drager UC, Hubel DH. Topography of visual and somatosensory projections to mouse superior colliculus. J Neurophysiol. 1976;39:91-101.
44. Hofbauer A, Drager UC. Depth segregation of retinal ganglion cells projecting to mouse superior colliculus. J Comp Neurol. 1985;234:1465-1474.
45. Schlichtenbrede FC, Smith AJ, Bainbridge JW, Thrasher AJ, Salt TE, Ali RR. Improvement of neuronal visual responses in the superior colliculus in Prph2(Rd2/Rd2) mice following gene therapy. Mol Cell Neurosci. 2004;25:103-110.
46. Cowan WM. Anterograde and retrograde transneuronal degeneration in the central and peripheral nervous system. In: Nauta WJH, Ebbesson SOE, eds. Contemporary Research Methods in Neuroanatomy. New York: Springer; 1970;217-251.
47. Tanaka H, Ito Y, Nakamura S, Masamitsu S, Hara H. Involvement of brain-derived neurotrophic factor in timedependent neurodegeneration in the murine superior colliculus after intravitreal injection of N-methyl-D-aspartate. Mol Vis. 2009;15:662-669.
48. Perez-Rico C, de la Villa P, Reinoso-Suarez F, Gomaz-Ramos P. Kainic acid intraocular injections during the postnatal critical period induce plastic changes in the visual system. Neurosci Res. 2009;63:244-250.
49. Kreutz MR, Weise J, Dieterich DC, et al. Rearrangement of the retino-collicular projection after partial optic nerve crush in the adult rat. Eur J Neurosci. 2004;19:247-257.
50. Gupta N, Yücel YH. What changes can we expect in the brain of glaucoma patients? Surv Ophthalmol. 2007;52:S122-S126.
51. Yücel YH, Zhang Q, Weinreb RN, Kaufman PL, Gupta N. Effects of retinal ganglion cell loss on magno-, parvo-, koniocellular pathways in the lateral geniculate nucleus and visual cortex in glaucoma. Prog Retin Eye Res. 2003;22:465-481.
52. Chaturvedi N, Hedley-Whyte ET, Dreyer EB. Lateral geniculate nucleus in glaucoma. Am J Ophthal. 1993;116:182-188.
53. Gupta N, Ang LC, Noël de Tilly L, Bidaisee L, Yücel YH. Human glaucoma and neural degeneration in intracranial optic nerve, lateral geniculate nucleus, and visual cortex. Br J Ophthalmol. 2006;90:674-678.
54. Gupta N, Greenberg G, Noël de Tilly L, Gray B, Polemidiotis M, Yücel YH. Atrophy of the lateral geniculate nucleus in human glaucoma by magnetic resonance imaging. Br J Ophthalmol. 2009;93:56-60.
55. Duncan RO, Sample PA, Weinreb RN, Bowd C, Zangwill LM. Retinotopic organization of primary visual cortex in glaucoma: comparing fMRI measurements of cortical function with visual field loss. Prog Retin Eye Res. 2007;26:38-56.
56. Gupta N, Yücel YH. Should we treat the brain in glaucoma? Can J Ophthalmol. 2007;42:409-413.