Gender differences of bleeding and stroke risk in very Old atrial fibrillation patients on VKA treatment: Results of the EPICA study on the behalf of FCSA (Italian Federation of Anticoagulation Clinics)

Thrombosis Research

Volumn 131, Issue 1, 2013, Pages 12-16

  Poli, Daniela ^a   Antonucci, Emilia ^b   Testa, Sophie ^c   Ageno, Walter ^d   Palareti, Gualtiero ^e  

^a CAREGGI UNIVERSITY HOSPITAL   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c Haemostasis and Thrombosis Centre   (Italy)

^d UNIVERSITY OF INSUBRIA   (Italy)

^e UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Atrial Fibrillation; Bleeding; Elderly; Vitamin K antagonist

Indexed keywords

ANTIVITAMIN K;

AGED; ARTERY DISEASE; ARTICLE; BLEEDING; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; FEMALE; FOLLOW UP; HEART ATRIUM FIBRILLATION; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OBSERVATIONAL STUDY; PRIORITY JOURNAL; SEX DIFFERENCE; TRANSIENT ISCHEMIC ATTACK; VASCULAR DISEASE;

AGE FACTORS; AGED, 80 AND OVER; ANTICOAGULANTS; ATRIAL FIBRILLATION; BRAIN ISCHEMIA; FEMALE; HEMORRHAGE; HUMANS; ITALY; MALE; MULTIVARIATE ANALYSIS; ODDS RATIO; PROPORTIONAL HAZARDS MODELS; RISK ASSESSMENT; RISK FACTORS; SEX FACTORS; STROKE; TIME FACTORS; TREATMENT OUTCOME; VITAMIN K;

EID: 84871663117     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2012.10.009     Document Type: Article

References (23)

1. S. Schulman, R.J. Beyth, C. Kearon, and M.N. Levine American College of Chest Physicians. Hemorrhagic complications of anticoagulant and thrombolytic treatment: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) Chest 133 2008 257S 298S (Pubitemid 351892969)
2. European Heart Rhythm Association; European Association for Cardio-Thoracic Surgery, A.J. Camm, P. Kirchhof, G.Y. Lip, U. Schotten, and I. Savelieva Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). European Heart Rhythm Association Eur Heart J 31 2010 2369 2429
3. D.L. Wolbrette Risk of proarrhythmia with class III antiarrhythmic agents: Sex-based differences and other issues Am J Cardiol 91 2003 39D 44D (Pubitemid 36372061)
4. M.C. Fang, D.E. Singer, Y. Chang, E.M. Hylek, L.E. Henault, and N.G. Jensvold Gender differences in the risk of ischemic stroke and peripheral embolism in atrial fibrillation: the AnTicoagulation and Risk factors In Atrial fibrillation (ATRIA) study Circulation 112 2005 1687 1691 (Pubitemid 41368143)
5. D. Poli, E. Antonucci, E. Grifoni, R. Abbate, G.F. Gensini, and D. Prisco Bleeding risk during oral anticoagulation in atrial fibrillation patients older than 80 years J Am Coll Cardiol 54 2009 999 1002
6. D. Poli, E. Antonucci, E. Grifoni, R. Abbate, G.F. Gensini, and D. Prisco Gender differences in stroke risk of atrial fibrillation patients on oral anticoagulant treatment Thromb Haemost 101 2009 938 942
7. J. Friberg, H. Scharling, N. Gadsbøll, T. Truelsen, and G.B. Jensen Copenhagen City Heart Study. Comparison of the impact of atrial fibrillation on the risk of stroke and cardiovascular death in women versus men (The Copenhagen City Heart Study) Am J Cardiol 94 2004 889 894 (Pubitemid 39359174)
8. G.Y. Lip, F. Andreotti, L. Fauchier, K. Huber, E. Hylek, and E. Knight Document reviewers: Collet JP, Rubboli A, Poli D, Camm J. Bleeding risk assessment and management in atrial fibrillation patients: a position document from the European Heart Rhythm Association, endorsed by the European Society of Cardiology Working Group on Thrombosis Europace 13 2011 723 746
9. D. Poli, E. Antonucci, S. Testa, A. Tosetto, W. Ageno, and G. Palareti Italian Federation of Anticoagulation Clinics. Bleeding risk in very old patients on vitamin K antagonist treatment: results of a prospective collaborative study on elderly patients followed by Italian Centres for Anticoagulation Circulation 124 2011 824 829
10. Report of the expert committee on the diagnosis and classification of diabetes mellitus Diabetes Care 26 2002 S5 S20
11. B.F. Gage, A.D. Waterman, W. Shannon, M. Boechler, M.W. Rich, and M.J. Radford Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation JAMA 285 2001 2864 2870 (Pubitemid 32537350)
12. B.F. Gage, C. van Walraven, L. Pearce, R.G. Hart, P.J. Koudstaal, and B.S. Boode Selecting patients with atrial fibrillation for anticoagulation: Stroke risk stratification in patients taking aspirin Circulation 110 2004 2287 2292 (Pubitemid 39407328)
13. G.Y. Lip, R. Nieuwlaat, R. Pisters, D.A. Lane, and H.J. Crijns Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: The euro heart survey on atrial fibrillation Chest 137 2010 263 272
14. R. Pisters, D.A. Lane, R. Nieuwlaat, C.B. de Vos, H.J. Crijns, and G.Y. Lip A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey Chest 138 2010 1093 1100
15. F.R. Rosendaal, S.C. Cannegieter, F.J.M. van der Meer, and E. Briet A method to determine the optimal intensity of oral anticoagulant therapy Thromb Haemost 69 1993 236 239 (Pubitemid 23069000)
16. P. Thorvaldsen, K. Asplund, K. Kuulasmaa, A.M. Rajakangas, and M. Schroll Stroke incidence, case fatality, and mortality in the WHO MONICA project.World Health Organization Monitoring Trends and Determinants in Cardiovascular Disease Stroke 26 1995 361 367
17. G. Palareti, N. Leali, S. Coccheri, M. Poggi, C. Manotti, and A. D'Angelo Bleeding complications of oral anticoagulant treatment: an inception-cohort, prospective collaborative study (ISCOAT). Italian Study on Complications of Oral Anticoagulant Therapy Lancet 348 1996 423 428 (Pubitemid 26267872)
18. J. Mant, F.D. Hobbs, K. Fletcher, A. Roalfe, D. Fitzmaurice, and G.Y. Lip BAFTA investigators; Midland Research Practices Network (MidReC). Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial Lancet 370 2007 493 503 (Pubitemid 47212371)
19. A.S. Go, E.M. Hylek, L.H. Borowsky, K.A. Phillips, J.V. Selby, and D.E. Singer Warfarin use among ambulatory patients with nonvalvular atrial fibrillation: the anticoagulation and risk factors in atrial fibrillation (ATRIA) study Ann Intern Med 131 1999 927 934 (Pubitemid 30005032)
20. H.I. Michelena, B.D. Powell, P.A. Brady, P.A. Friedman, and M.D. Ezekowitz Gender in atrial fibrillation: Ten years later Gend Med 7 2010 206 217
21. Adjusted-dose warfarin versus low-intensity, fixed dose warfarin plus aspirin for high-risk patients with atrial fibrillation: Stroke Prevention in AtrialFibrillation III randomised clinical trial Lancet 348 1996 633 638
22. N. Dagres, R. Nieuwlaat, P.E. Vardas, D. Andresen, S. Lévy, and S. Cobbe Gender related differences in presentation, treatment, and outcome of patients with atrial fibrillation in Europe: A report from the Euro Heart Survey on Atrial Fibrillation J Am Coll Cardiol 49 2007 572 577 (Pubitemid 46177436)
23. M. Hughes, and G.Y. Lip for the Guideline Development Group for the NICE national clinical guideline for management of atrial fibrillation in primary and secondary care. Risk factors for anticoagulation related bleeding complications in patients with atrial fibrillation: A systematic review QJM 100 2007 599 607