The origin of stroma surrounding epithelial ovarian cancer cells

International Journal of Gynecological Pathology

Volumn 32, Issue 1, 2013, Pages 26-30

  Akahane, Tomoko ^a   Hirasawa, Akira ^a   Tsuda, Hiroshi ^a   Kataoka, Fumio ^a   Nishimura, Sadako ^a   Tanaka, Hideo ^a   Tominaga, Eiichiro ^a   Nomura, Hiroyuki ^a   Chiyoda, Tatsuyuki ^a   Iguchi, Yoko ^a   Yamagami, Wataru ^a   Susumu, Nobuyuki ^b   Aoki, Daisuke ^a  

^a KEIO UNIVERSITY   (Japan)

^b OSAKA CITY GENERAL HOSPITAL   (Japan)

Author keywords

Ovarian cancer; p53; Stroma

Indexed keywords

PROTEIN P53;

ADULT; AGED; ARTICLE; CANCER CELL; CANCER TISSUE; CLINICAL ARTICLE; CONTROLLED STUDY; EXON; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MUTATIONAL ANALYSIS; OVARY CARCINOMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; STROMA;

ADULT; AGED; CONNECTIVE TISSUE; FEMALE; GENES, P53; HUMANS; IMMUNOHISTOCHEMISTRY; LASER CAPTURE MICRODISSECTION; MIDDLE AGED; MUTATION; NEOPLASM GRADING; NEOPLASM STAGING; NEOPLASMS, GLANDULAR AND EPITHELIAL; OVARIAN NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR MICROENVIRONMENT; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84871658593     PISSN: 02771691     EISSN: 15387151     Source Type: Journal    
DOI: 10.1097/PGP.0b013e3182518533     Document Type: Article

References (19)

1. Bhowmick NA, Moses HL. Tumor-stroma interactions. Curr Opin Genet Dev 2005;15:97-101. (Pubitemid 40127637)
2. Kim JB, Stein R, O'Hare MJ. Tumour-stromal interactions in breast cancer: the role of stroma in tumourigenesis. Tumour Biol 2005;26:173-85. (Pubitemid 41379743)
3. Tlsty TD, Coussens LM. Tumor stroma and regulation of cancer development. Annu Rev Pathol 2006;1:119-50.
4. Finak G, Bertos N, Pepin F, et al. Stromal gene expression predicts clinical outcome in breast cancer. Nat Med 2008;14: 518-27. (Pubitemid 351655218)
5. Kataoka F, Tsuda H, Arao T, et al. EGR1 and FOSB gene expression in cancer stroma are independent prognostic indicators for epithelial ovarian cancer receiving standard therapy. Genes Chromosomes Cancer 2012;51:300-12.
6. Ishii G, Ito TK, Aoyagi K, et al. Presence of human circulating progenitor cells for cancer stromal fibroblasts in the blood of lung cancer patients. Stem Cells 2007;25:1469-77. (Pubitemid 47106015)
7. Chiba H, Ishii G, Ito TK, et al. CD105-positive cells in pulmonary arterial blood of adult human lung cancer patients include mesenchymal progenitors. Stem Cells 2008;26: 2523-30.
8. Kurose K, Gilley K, Matsumoto S, et al. Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas. Nat Genet 2002;32:355-57. (Pubitemid 35266108)
9. Patocs A, Zhang L, Xu Y, et al. Breast-cancer stromal cells with TP53 mutations and nodal metastases. N Engl J Med 2007;357:2543-51. (Pubitemid 350294221)
10. Tsuda H, Birrer MJ, Ito YM, et al. Identification of DNA copy number changes in microdissected serous ovarian cancer tissue using a cDNA microarray platform. Cancer Genet Cytogenet 2004;155:97-107. (Pubitemid 39574919)
11. Tsuda H, Ito YM, Ohashi Y, et al. Identification of overexpression and amplification of ABCF2 in clear cell ovarian adenocarcinomas by cDNA microarray analyses. Clin Cancer Res 2005;11:6880-8. (Pubitemid 41428744)
12. Heinmoller E, Liu Q, Sun Y, et al. Toward efficient analysis of mutations in single cells from ethanol-fixed, paraffin-embedded, and immunohistochemically stained tissues. Lab Invest 2002;82:443-53. (Pubitemid 34311116)
13. Akahane T, Sekizawa A, Purwosunu Y, et al. The role of p53 mutation in the carcinomas arising from endometriosis. Int J Gynecol Pathol 2007;26:345-51. (Pubitemid 46986074)
14. Qiu W, Hu M, Sridhar A, et al. No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas. Nat Genet 2008;40: 650-55. (Pubitemid 351601206)
15. Kato K, Takao T, Kuboyama A, et al. Endometrial cancer side-population cells show prominent migration and have a potential to differentiate into the mesenchymal cell lineage. Am J Pathol 2010;176:381-92.
16. Hashiguchi Y, Tsuda H, Yamamoto K, et al. Combined analysis of p53 and RB pathways in epithelial ovarian cancer. Hum Pathol 2001;32:988-96. (Pubitemid 32911323)
17. Hall PA, McKee PH, Menage HD, et al. High levels of p53 protein in UV-irradiated normal human skin. Oncogene 1993;8:203-7. (Pubitemid 23047248)
18. Graeber TG, Osmanian C, Jacks T, et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 1996;379:88-91. (Pubitemid 26008141)
19. Momand J, Zambetti GP, Olson DC, et al. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992;69: 1237-45.