Peptido sulfonyl fluorides as new powerful proteasome inhibitors

Journal of Medicinal Chemistry

Volumn 55, Issue 24, 2012, Pages 10995-11003

  Brouwer, Arwin J ^a   Jonker, Anika ^a   Werkhoven, Paul ^a   Kuo, Ethan ^b   Li, Nan ^b   Gallastegui, Nerea ^c   Kemmink, Johan ^a   Florea, Bogdan I ^b   Groll, Michael ^c   Overkleeft, Herman S ^b   Liskamp, Rob M J ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BORTEZOMIB; EPOXOMICIN; PEPTIDO SULFONYL FLUORIDE DERIVATIVE; PROTEASOME; PROTEASOME INHIBITOR; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROPHILICITY; HUMAN; HUMAN CELL; IC 50;

HEK293 CELLS; HUMANS; PEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; PROTEIN SUBUNITS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES;

EID: 84871643550     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301443r     Document Type: Article

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