Effects of in vivo applications of peripheral blood-derived mesenchymal stromal cells (PB-MSCs) and platlet-rich plasma (PRP) on experimentally injured deep digital flexor tendons of sheep

Journal of Orthopaedic Research

Volumn 31, Issue 2, 2013, Pages 306-314

  Martinello, Tiziana ^a   Bronzini, Ilaria ^a   Perazzi, Anna ^a   Testoni, Stefania ^a   De Benedictis, Gulia Maria ^a   Negro, Alessandro ^a   Caporale, Giovanni ^a   Mascarello, Francesco ^a   Iacopetti, Ilaria ^a   Patruno, Marco ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

adult stem cells; peripheral blood derived mesenchymal stromal cells (PB MSCs); platelet rich plasma (PRP); tendon injuries

Indexed keywords

CARTILAGE OLIGOMERIC MATRIX PROTEIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DEEP DIGITAL FLEXOR TENDON INJURY; EXTRACELLULAR MATRIX; FEMALE; FLEXOR TENDON INJURY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MESENCHYMAL STROMA CELL; NONHUMAN; PERIPHERAL BLOOD DERIVED MESENCHYMAL STROMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHEEP; THROMBOCYTE RICH PLASMA; WOUND HEALING;

ANIMALS; COLLAGEN TYPE I; COLLAGEN TYPE III; COLLAGENASES; DRUG SYNERGISM; EXTRACELLULAR MATRIX PROTEINS; FEMALE; GLYCOPROTEINS; HINDLIMB; MESENCHYMAL STEM CELL TRANSPLANTATION; PLATELET-RICH PLASMA; SHEEP, DOMESTIC; TENDON INJURIES; WOUND HEALING;

EID: 84871616337     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.22205     Document Type: Article

References (25)

1. Dahlgren LA, Mohammed HO, Nixon AJ,. 2005. Temporal expression of growth factors and matrix molecules in healing tendon lesions. J Orthop Res 23: 84-92.
2. Williams RB, Harkins LS, Hammond CJ, et al. 2001. Racehorse injuries, clinical problems and fatalities recorded on British racecourses from flat racing and National Hunt racing during 1996, 1997 and 1998. Equine Vet J 33: 478-486.
3. Reardon RJM, Boden LA, Mellor DJ, et al. 2012. Risk factors for superficial digital flexor tendinopathy in Thoroughbred racehorses in hurdle starts in the UK (2001-2009). Equine Vet J 28: 1-6.
4. Hoffmann A, Gross G,. 2007. Tendon and ligament engineering in the adult organism: mesenchymal stem cells and gene-therapeutic approaches. Int Orthop 31: 791-797.
5. Godwin EE, Young NJ, Dudhia J, et al. 2012. Implantation of bone marrow-derived mesenchymal stem cells demonstrates improved outcome in horses with overstrain injury of the superficial digital flexor tendon. Equine Vet J 44: 25-32.
6. Guest DJ, Smith MRW, Allen WR,. 2008. Monitoring the fate of autologous and allogeneic mesenchymal progenitor cells injected into the superficial digital flexor tendon of horses: preliminary study. Equine Vet J 40: 178-181.
7. Nixon AJ, Watts AE, Schnabel LV,. 2012. Cell- and gene-based approaches to tendon regeneration. J Shoulder Elb Surg 21: 278-294.
8. Crovace A, Lacitignola L, De Siena R, et al. 2007. Cell therapy for tendon repair in horses: an experimental study. Vet Res Commun 31: 281-283.
9. Koch TG, Berg LC, Betts DH,. 2009. Review Article Compte rendu medicine. Can Vet J 50: 155-165.
10. Cornali M, Carlin S, Ferrari M, et al. 2011. Application of autologous mesenchymal stem cells (MSCs) and platelet rich plasma (PRP) for the treatment of tendon-ligament injuries in thoroughbred racehorses. Ippologia 4: 1-7.
11. Murphy JM, Fink DJ, Hunziker EB, et al. 2003. Stem cell therapy in a caprine model of osteoarthritis. Arthritis Rheuma 48: 3464-3474.
12. Caplan AI,. 2007. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J Cell Physiol 21: 341-347.
13. Schnabel LV, Mohammed HO, Miller BJ, et al. 2007. Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons. J Orthop Res 25: 230-240.
14. Anitua E, Sánchez M, Orive G, et al. 2008. Delivering growth factors for therapeutics. Trends Pharmacol Sci 29: 37-41.
15. Maia L, de Souza MV, Ribeiro Júnior JI, et al. 2009. Platelet-rich plasma in the treatment of induced tendinopathy in horses: histologic evaluation. J Equine Vet Sci 29: 618-626.
16. Bosch G, van Schie HTM, de Groot MW, et al. 2010. Effects of platelet-rich plasma on the quality of repair of mechanically induced core lesions in equine superficial digital flexor tendons: a placebo-controlled experimental study. J Orthop Res 28: 211-217.
17. Zhang J, Wang JH-C,. 2010. Platelet-rich plasma releasate promotes differentiation of tendon stem cells into active tenocytes. Am J Sport Med 38: 2477-2486.
18. Martinello T, Bronzini I, Maccatrozzo L, et al. 2010. Cryopreservation does not affect the stem characteristics of multipotent cells isolated from equine peripheral blood. Tissue Eng 16: 771-781.
19. Crovace A, Lacitignola L, Rossi G, et al. 2010. Histological and immunohistochemical evaluation of autologous cultured bone marrow mesenchymal stem cells and bone marrow mononucleated cells in collagenase-induced tendinitis of equine superficial digital flexor tendon. Vet Med Int 2010: 10. DOI: 10.4061/2010/250978
20. Dehghan MM, Mehrjerdi HK, Masoudifard M, et al. 2007. Clinical and ultrasonographic findings of collagenase induced tendinitis in the horse. Iran J Vet Surg 2: 47-58.
21. Nixon AJ, Dahlgren LA, Haupt JL, et al. 2008. Effect of adipose-derived nucleated cell fraction on tendon repair in horses with collagenase-induced tendinitis. Am J Vet Res 69: 928-937.
22. Arguelles D, Carmona JU, Climent F, et al. 2008. Autologous platelet concentrates as a treatment for musculoskeletal lesions in five horses. Vet Rec 162: 208-211.
23. Schnabel LV, Lynch ME, van der Meulen MCH, et al. 2009. Mesenchymal stem cells and insulin-like growth factor-I gene-enhanced mesenchymal stem cells improve structural aspects of healing in equine flexor digitorum superficialis tendons. J Orthop Res 27: 1392-1398.
24. Guest DJ, Smith MRW, Allen WR,. 2010. Equine embryonic stem-like cells and mesenchymal stromal cells have different survival rates and migration patterns following their injection into damaged superficial digital flexor tendon. Equine Vet J 42: 636-642.
25. Beck S, Blunden T, Dyson S, et al. 2011. Are matrix and vascular changes involved in the pathogenesis of deep digital flexor tendon injury in the horse? Vet J (London, England: 1997) 189: 289-295.