The COMT Val/Met polymorphism is associated with reading-related skills and consistent patterns of functional neural activation

Developmental Science

Volumn 16, Issue 1, 2013, Pages 13-23

  Landi, Nicole ^a   Frost, Stephen J ^a   Mencl, W Einar ^a   Preston, Jonathan L ^a   Jacobsen, Leslie K ^a   Lee, Maria ^a   Yrigollen, Carolyn ^a   Pugh, Kenneth R ^a   Grigorenko, Elena L ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL METHYLTRANSFERASE;

ARTICLE; CHILD; COGNITION; FRONTAL LOBE; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSIOLOGY; POLYMERASE CHAIN REACTION; READING; VERBAL BEHAVIOR;

CATECHOL O-METHYLTRANSFERASE; CHILD; COGNITION; FRONTAL LOBE; GENOTYPE; HUMANS; MAGNETIC RESONANCE IMAGING; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; READING; VERBAL BEHAVIOR;

EID: 84871612702     PISSN: 1363755X     EISSN: 14677687     Source Type: Journal    
DOI: 10.1111/j.1467-7687.2012.01180.x     Document Type: Article

References (45)

1. Barnett, J.H., Scoriels, L., & Munafò, M.R (2008). Meta-analysis of the cognitive effects of the catechol-O-methyltransferase gene Val158/108Met polymorphism. Biological Psychiatry, 64, 137-144.
2. Bertolino, A., Rubino, V., Sambataro, F., Blasi, G., Latorre, V., Fazio, L., Caforio, G., Petruzzella, V., Kolachana, B., Hariri, A., Meyer-Lindenberg, A., Nardini, M., Weinberger, D.R., & Scarabino, T. (2006). Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotype. Biological Psychiatry, 60, 1250-1258.
3. Bishop, S.J., Fossella, J., Croucher, C.J., & Duncan, J. (2008). COMT val158met genotype affects recruitment of neural mechanism supporting fluid intelligence. Cerebral Cortex, 18, 2132-2140.
4. Blasi, G., Mattay, V.S., Bertolino, A., Elvevag, B., Callicott, J.H., Das, S., Kolachana, B.S., Egan, M.F., Goldberg, T.E., & Weinberger, D.R. (2005). Effect of catechol- O-methyltransferase val158metgenotype on attentional control. Journal of Neuroscience, 25, 5038-5045.
5. Caldu, X., Vendrell, P., Bartres-Faz, D., Clemente, I., Bargallo, N., Jurado, M.A., Serra- Grabulosa, J.M., & Junqué, C. (2007). Impact of the COMT Val108/158 Met and DAT genotypes on prefrontal function in healthy subjects. NeuroImage, 37, 1437-1444.
6. Chen, J., Lipska, B., Halim, N., Quang, D.M., Matsumoto, M., Melhem, S., Kolachana, B.S., Hyde, T.M., Herman, M., Apud, J., Egan, M., Kleinman, J.E., & Weinberger, D.R. (2004). Functional analysis of genetic variation in catechol-omethyltransferase (COMT): effects of mRNA, protein, and enzyme activity in postmortem human brain. American Journal of Human Genetics, 75, 807-821.
7. Drabant, E.M., Hariri, A.R., Meyer-Lindenberg, A., Munoz, K.E., Mattay, V.S., Kolachana, B.S., Egan, M.F., & Weinberger, D.R. (2006). Catechol O-methyltransferase ValÂ1-sup-5-sup-8Met genotype and neural mechanisms related to affective arousal and regulation. Archives of General Psychiatry, 63, 1396-1406.
8. Egan, M.F., Goldberg, T.E., Kolachana, B.S., Callicott, J.H., Mazzanti, C.M., Straub, R.E., Goldman, D., & Weinberger, D.R. (2001). Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proceedings of the National Academy of Sciences, USA, 98, 6917-6922.
9. Fletcher, J. (2009). Dyslexia: the evolution of a scientific concept. Journal of the International Neuropsychological Society, 15, 501-508.
10. Friston, K.J., Ashburner, J., Frith, C.D., Poline, J.-B., Heather, J.D., & Frackowiak, R.S.J. (1995). Spatial registration and normalization of images. Human Brain Mapping, 2, 165-189.
11. Frost, S.J., Landi, N., Mencl, W.E., Sandak, R., Fulbright, R.K., Tejada, E.T., Jacobsen, L., Grigorenko, E.L., Constable, R.T., & Pugh, K.R. (2009). Phonological awareness predicts activation patterns for print and speech. Annals of Dyslexia, 59, 78-97.
12. Genovese, C.R., Lazar, N.A., & Nichols, T. (2002). Thresholding of statistical maps in functional neuroimaging using the false discovery rate. NeuroImage, 15, 870-878.
13. 158Met allele with ADHD and OCD in subjects with velocardiofacial syndrome. International Journal of Neuropsychopharmacology, 10, 301-308.
14. Grigorenko, E.L., Deyoung, C.G., Getchell, M., Haeffel, G.J., Klinteberg, B.A.F., Koposov, R.A., Oreland, L., Pakstis, A.J., Ruchkin, V.V., & Yrigollen, C.M. (2007). Exploring interactive effects of genes and environments in etiology of individual differences in reading comprehension. Developmental Psychopathology, 19, 1089-1103.
15. Jorm, A.F, Share, D.L., Maclean, R., & Matthews, R. (1986). Cognitive factors at school entry predictive of specific reading retardation and general reading backwardness: a research note. Journal of Child Psychology and Psychiatry, 27, 45-54.
16. Kempton, M.J., Haldane, M., Jogia, J., Christodoulou, T., Powell, J., Collier, D., Williams, S.C., & Frangou, S. (2008). The effects of gender and COMT Val158Met polymorphism on fearful facial affect recognition: a fMRI study. International Journal Neuropsychopharmacology, 12, 371-381.
17. Landi, N. (2010). An examination of the relationship between reading comprehension, higher-level and lower-level reading sub-skills in adults. Reading and Writing, 23, 701-717.
18. Landi, N., Mencl, W.E., Frost, S.J., Sandak, R., Chen, H., & Pugh, K.R. (2010). An fMRI comparison of semantic and phonological processing in non-impaired and reading disabled adolescents. Annals of Dyslexia, 60, 102-121.
19. Lebedeva, L.S., Korovaitseva, G.I., Lezheiko, T.V., Kaleda, V.G., Abramova, L.I., Barkhatova, A.N., & Golimbet, V.E. (2009). Influence of genetic variants modulating dopamine activity on brain processing of auditory information (the P300 paradigm). Human Physiology, 35, 21-24.
20. Locascio, G., Mahone, E.M., Eason, S.H., & Cutting, L.E. (2010). Executive dysfunction among children with reading comprehension deficits. Journal of Learning Disabilities, 43, 441-454.
21. Lyon, G., Shaywitz, S., & Shaywitz, B. (2003). A definition of dyslexia. Annals of Dyslexia, 53, 1-14.
22. Mattay, V.S., Goldberg, T.E., Fera, F., Hariri, A.R., Tessitore, A., Egan, M.F., Kolachana, B., Callicott, J.H., & Weinberger, D.R. (2003). Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine. Proceedings of the National Academy of Sciences, USA, 100, 6186-6191.
23. Mechelli, A., Tognin, S., McGuire, P.K., Prata, D., Sartori, G., Fusar-Poli, P., De Brito, S., Hariri, A.R., & Viding, E. (2009). Genetic vulnerability to affective psychopathology in childhood: a combined voxel-based morphometry and functional magnetic resonance imaging study. Biological Psychiatry, 66, 231-237.
24. Mier, D., Kirsh, P., & Mayer-Lindenberg, A. (2010). Neural substrates of pleiotropic action of genetic variation in COMT: a meta-analysis. Molecular Psychiatry, 15, 918-927.
25. Miezin, F.M., Maccotta, L., Ollinger, J.M., Petersen, S.E., & Buckner, R.L. (2000). Characterizing the haemodynamic response: effects of presentation rate, sampling procedure, and the possibility of ordering brain activity based on relative timing. NeuroImage, 11, 735-759.
26. Papademetris, X., Jackowski, A., Schultz, R.T., Staib, L.H., & Duncan, J.S. (2003). Computing 3D non-rigid brain registration using extended robust point matching for composite multisubject fMRI analysis. Medical Image Computing and Computer Aided Intervention (MICCAI) Part II LLNCS 2879 (pp. 788-795). New York: Springer-Verlag.
27. Preston, J.L., Felsenfeld, S.F., Frost, S.J., Mencl, W.E., Fulbright, R.K., Grigorenko, E., Landi, N., & Pugh, K.R. (in press). Functional brain activation differences in school-age children with speech sound errors: speech and print processing. Journal of Speech, Language and Hearing Research. doi:10.1044/1092-4388(2011/11-0056).
28. Preston, J.L., Frost, S., Mencl, W.E., Fulbright, R.K., Landi, N., Grigorenko, E., Jacobsen, L., & Pugh, K.R. (2010). Early and late talkers: school-age language, literacy and neurolinguistic differences. Brain, 133, 2185-2195.
29. Psychological Corporation (1999). Wechzrsler Abbreviated Scale of Intelligence. San Antonio, TX: Harcourt Brace & Co.
30. Pugh, K.R., Frost, S.J., Sandak, R., Landi, N., Rueckl, J.G., Constable, R.T., Seidenberg, M.S., Fulbright, R.K., Katz, L., & Mencl, W.E. (2008). Effects of stimulus difficulty and repetition on printed word identification: an fMRI comparison of nonimpaired and reading-disabled adolescent cohorts. Journal of Cognitive Neuroscience, 20, 1146-1160.
31. Pugh, K.R., Landi, N., Preston, J.L., Mencl, W.E., Austin, A., Sibley, D., Fulbright, R.K., Seidenberg, M.S., Grigorenko, E., Constable, R.T., Molfese, P., & Frost, S.J. (in press). The relationship between phonological and sensorimotor processing skills and the neurocircuitry for reading in emergent readers. Brain and Language.
32. Pugh, K.R., Mencl, W.E., Jenner, A.R., Katz, L., Frost, S.J., Lee, J.R., Shaywitz, S.E., & Shaywitz, B.A. (2000). Functional neuroimaging studies of reading and reading disability (developmental dyslexia). Mental Retardation & Developmental Disabilities Research Reviews, 6, 207-213.
33. Schott, B.H., Seidenbecher, C.I., Fenker, D.B., Lauer, C.J., Bunzeck, N., Bernstein, H.G., Tischmeyer, W., Gundelfinger, E.D., Heinze, H.J., & Düzel, E. (2006). The dopaminergic midbrain participates in human episodic memory formation: evidence from genetic imaging. Journal of Neuroscience, 26, 1407-1417.
34. Shaywitz, S.E., Escobar, M.D., Shaywitz, B.A., Fletcher, J.M., & Makuch, R.W. (1992). Evidence that dyslexia may represent the lower tail of a normal distribution of reading ability. New England Journal of Medicine, 326, 145-150.
35. Shaywitz, B.A., Shaywitz, S.E., Pugh, K.R., Mencl, W.E., Fulbright, R.K., Skudlarski, P., Constable, R.T., Marchione, K.E., Fletcher, J.M., Lyon, G.R., & Gore, J.C. (2002). Disruption of posterior brain systems for reading in children with developmental dyslexia. Biological Psychiatry, 52, 101-110.
36. Smolka, M.N., Bühler, M., Schumann, G., Klein, S., Hu, X.Z., Moayer, M., Zimmer, A., Wrase, J., Flor, H., Mann, K., Braus, D.F., Goldman, D., & Heinz, A. (2007). Gene-gene effects on central processing of adverse stimuli. Molecular Psychiatry, 12, 307-317.
37. Smolka, M.N., Schumann, G., Wrase, J., Grusser, S.M., Flor, H., Mann, K., Braus, D.F., Goldman, D., Büchel, C., & Heinz, A. (2005). Catechol-O- methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex. Journal of Neuroscience, 25, 836-842.
38. Stevenson, J. (1988). Which aspects of reading disability show a 'hump' in their distribution? Applied Cognitive Psychology, 2, 77-85.
39. Stokes, P.R., Rhodes, R.A., Grasby, P.M., & Mehta, M.A. (2011). The effects of the COMT val (108/158)met polymorphism on BOLD activation during working memory, planning, and response inhibition: a role for the posterior cingulate cortex? Neuropsychopharmacology, 36, 763-771.
40. Tan, H.Y., Chen, Q., Goldberg, T.E., Mattay, V.S., Meyer-Lindenberg, A., Weinberger, D.R., & Callicot, J.H. (2007). Catechol-O-methyltransferase Val158Met modulation of prefrontal-parietal-striatal brain systems during arithmetic and temporal transformations in working memory. Journal of Neuroscience, 27, 13393-13401.
41. Ullman, M.T., & Pierpont, E.I. (2005). Specific language impairment is not specific to language: the procedural deficit hypothesis. Cortex, 41, 399-433.
42. Wagner, R.K., Torgesen, J.K., & Rashotte, C.A. (1999). Comprehensive Test of Phonological Processing. Austin, TX: Pro-Ed.
43. Wahlstrom, D., White, T., Hooper, C.J., Vrshek-Schallhorn, S., Oetting, W.S., Brott, M.J., & Luciana, M. (2007). Association of the Catechol-O-methyltransferase (COMT) gene to prefrontally-mediated cognitions in adolescents. Biological Psychiatry, 61, 626-632.
44. Wahlstrom, D., White, T., & Luciana, M. (2010). Neurobehavioral evidence for changes in dopamine system activity during adolescence. Neuroscience and Biobehavioral Reviews, 34, 631-648.
45. Woodcock, R.W., McGrew, K.S., & Mather, N. (2001). Woodcock-Johnson III NU tests of achievement. Rolling Meadows, IL: Riverside Publishing.