B RAF KINASE INHIBITOR;
DABRAFENIB;
TRAMETINIB;
VEMURAFENIB;
ANTINEOPLASTIC AGENT;
B RAF KINASE;
BRAF PROTEIN, HUMAN;
MAP2K1 PROTEIN, HUMAN;
MITOGEN ACTIVATED PROTEIN KINASE KINASE 1;
CANCER COMBINATION CHEMOTHERAPY;
DRUG CHOICE;
DRUG COST;
DRUG EFFICACY;
DRUG RESPONSE;
DRUG SAFETY;
HUMAN;
MELANOMA;
MOLECULARLY TARGETED THERAPY;
MONOTHERAPY;
NOTE;
PRIORITY JOURNAL;
PROGRESSION FREE SURVIVAL;
RISK ASSESSMENT;
SKIN CARCINOMA;
TREATMENT OUTCOME;
ARTICLE;
DRUG ANTAGONISM;
DRUG EFFECT;
PHASE 2 CLINICAL TRIAL (TOPIC);
PROGNOSIS;
SECOND CANCER;
SIGNAL TRANSDUCTION;
ANTINEOPLASTIC AGENTS;
CLINICAL TRIALS, PHASE II AS TOPIC;
HUMANS;
MAP KINASE KINASE 1;
MELANOMA;
MOLECULAR TARGETED THERAPY;
NEOPLASMS, SECOND PRIMARY;
PROGNOSIS;
PROTO-ONCOGENE PROTEINS B-RAF;
SIGNAL TRANSDUCTION;
Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy
Paraiso, K. H. et al. Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy. Br. J. Cancer 102, 1724-1730 (2010).
Development of colonic adenomas and gastric polyps in BRAF mutant melanoma patients treated with vemurafenib [abstract]
Chapman, P. B. et al. Development of colonic adenomas and gastric polyps in BRAF mutant melanoma patients treated with vemurafenib [abstract]. Pigment Cell Melanoma Res. 25, 847 (2012).
Colorectal cancer promoted in a melanoma patient receiving dabrafenib (GSK2118436) in combination with MEK1/2 inhibitor trametinib (GSK1120212) [abstract]
Andrews, M. et al. Colorectal cancer promoted in a melanoma patient receiving dabrafenib (GSK2118436) in combination with MEK1/2 inhibitor trametinib (GSK1120212) [abstract]. Pigment Cell Melanoma Res. 25, 842 (2012).
Randomized phase II trial of sorafenib with temsirolimus or tipifarnib in untreated metastatic melanoma (S0438)
Margolin, K. A. et al. Randomized phase II trial of sorafenib with temsirolimus or tipifarnib in untreated metastatic melanoma (S0438). Clin. Cancer Res. 18, 1129-1137 (2012).