A fluorogenic phospholipid for the detection of lysosomal phospholipase A2 activity

Analytical Biochemistry

Volumn 434, Issue 1, 2013, Pages 78-83

  Abe, Akira ^a   Rzepecki, Piotr W ^b   Shayman, James A ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b Echelon Biosciences   (United States)

Author keywords

Amiodarone; Cationic amphiphilic drug; Fluorophore; Fluoxetine; Lysosome; Phosphatidylgycerol; Phospholipase A2; Phospholipidosis

Indexed keywords

AMIDES; DYES; FLUORESCENCE; FLUOROPHORES; KETONES; LIPOSOMES; MAMMALS; PHOSPHOLIPIDS;

AMIODARONE; AMPHIPHILIC DRUGS; FLUOXETINE; LYSOSOME; PHOSPHATIDYLGYCEROL; PHOSPHOLIPASE A2; PHOSPHOLIPIDOSIS;

DRUG DELIVERY;

1,2 DIOLEOYL PHOSPHATIDYLCHOLINE; 4 (4 DIMETHYLAMINOPHENYLAZO)BENZOYL; AMIODARONE; BENZENE DERIVATIVE; FLUOROGENIC PHOSPHATIDYLGLYCEROL; FLUOXETINE; LYSOSOMAL PHOSPHOLIPASE A2; LYSOSOME ENZYME; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLGLYCEROL; PHOSPHOLIPASE A2; PHOSPHOLIPID; PHOSPHORAMIDOUS ACID; UNCLASSIFIED DRUG;

ARTICLE; DRUG EFFECT; ENZYME ACTIVITY; FLUORESCENCE; IC 50; MICROPLATE READER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS;

MUS;

EID: 84871575995     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2012.11.004     Document Type: Article

References (13)

1. J.A. Shayman, R. Kelly, J. Kollmeyer, Y. He, and A. Abe Group XV phospholipase A, a lysosomal phospholipase A Prog. Lipid Res. 50 2011 1 13
2. A. Abe, M. Hiraoka, S. Wild, S.E. Wilcoxen, R. Paine 3rd, and J.A. Shayman Lysosomal phospholipase A2 is selectively expressed in alveolar macrophages J. Biol. Chem. 279 2004 42605 42611
3. M. Hiraoka, A. Abe, Y. Lu, K. Yang, X. Han, R.W. Gross, and J.A. Shayman Lysosomal phospholipase A2 and phospholipidosis Mol. Cell. Biol. 26 2006 6139 6148
4. A. Abe, M. Hiraoka, and J.A. Shayman A role for lysosomal phospholipase A2 in drug induced phospholipidosis Drug Metab. Lett. 1 2007 49 53
5. J.A. Shayman, A. Abe, Drug induced phospholipidosis: an acquired lysosomal storage disorder, Biochim. Biophys. Acta, in press, http://dx.doi.org/10.1016/j.bbalip.2012.08.013.
6. A. Abe, R. Kelly, J. Kollmeyer, M. Hiraoka, Y. Lu, and J.A. Shayman The secretion and uptake of lysosomal phospholipase A2 by alveolar macrophages J. Immunol. 181 2008 7873 7881
7. A. Abe, R. Kelly, and J.A. Shayman The measurement of lysosomal phospholipase A2 activity in plasma J. Lipid Res. 51 2010 2464 2470
8. A. Abe, M. Hiraoka, S. Inatomi, I. Ohguro, and H. Ohguro Lysosomal phospholipase A2 activity in pig aqueous humor Invest. Ophthalmol. Vis. Sci. 53 2012 152 156
9. T.M. Rose, and G.D. Prestwich Fluorogenic phospholipids as head group-selective reporters of phospholipase A activity ACS Chem. Biol. 1 2006 83 91
10. A. Abe, and J.A. Shayman The role of negatively charged lipids in lysosomal phospholipase A2 function J. Lipid Res. 50 2009 2027 2035
11. A.M. Sautereau, C. Tournaire, M. Suares, J.F. Tocanne, and N. Paillous Interactions of amiodarone with model membranes and amiodarone-photoinduced peroxidation of lipids Biochem. Pharmacol. 43 1992 2559 2566
12. P. Nioi, B.K. Perry, E.J. Wang, Y.Z. Gu, and R.D. Snyder In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies Toxicol. Sci. 99 2007 162 173
13. M. Natalie, S. Margino, H. Erik, P. Annelieke, V. Geert, and V. Philippe A 96-well flow cytometric screening assay for detecting in vitro phospholipidosis-induction in the drug discovery phase Toxicol. In Vitro 23 2009 217 226