Assessment of the association between colchicine therapy and serious adverse events

Pharmacotherapy

Volumn 32, Issue 11, 2012, Pages 974-980

  Todd, Brittany A ^a,b   Billups, Sarah J ^a,b   Delate, Thomas ^a,b   Canty, Kara E ^a   Kauffman, Amy B ^a,b   Rawlings, Julia E ^a,b   Wagner, Theresa M ^a  

^a KAISER PERMANENTE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Aplastic anemia; Blood dyscrasia; Colchicine; Creatine kinase; Leukopenia; Myotoxicity; Neutropenia; RhabdomyolysisThrombocytopenia

Indexed keywords

AMPRENAVIR; APREPITANT; ATAZANAVIR; ATORVASTATIN; CLARITHROMYCIN; COLCHICINE; CREATINE KINASE; CYCLOSPORIN; DARUNAVIR PLUS RITONAVIR; DIGOXIN; DILTIAZEM; ERYTHROMYCIN; FLUCONAZOLE; FLUINDOSTATIN; FOSAMPRENAVIR; INDINAVIR; ITRACONAZOLE; KETOCONAZOLE; LOPINAVIR PLUS RITONAVIR; MEVINOLIN; NEFAZODONE; NELFINAVIR; PRAVASTATIN; RANOLAZINE; RITONAVIR PLUS SAQUINAVIR; ROSUVASTATIN; SIMVASTATIN; TELITHROMYCIN; UNINDEXED DRUG; VERAPAMIL;

ADULT; APLASTIC ANEMIA; ARTICLE; BLOOD DYSCRASIA; BLOOD TOXICITY; CHRONIC DRUG ADMINISTRATION; CLINICAL ASSESSMENT; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DISEASE ASSOCIATION; DRUG POTENTIATION; FEMALE; GOUT; HUMAN; KIDNEY FAILURE; LEUKOPENIA; LIVER DYSFUNCTION; LONG TERM EXPOSURE; MAJOR CLINICAL STUDY; MALE; MUSCLE DISEASE; MYOTOXICITY; NEUTROPENIA; PANCYTOPENIA; RISK ASSESSMENT; RISK FACTOR; SCORING SYSTEM; SIDE EFFECT; THROMBOCYTOPENIA; TREATMENT OUTCOME;

ADULT; AGED; CASE-CONTROL STUDIES; COHORT STUDIES; COLCHICINE; COLORADO; CYTOCHROME P-450 CYP3A; DRUG INTERACTIONS; DRUG-INDUCED LIVER INJURY; ELECTRONIC HEALTH RECORDS; ENZYME INHIBITORS; FEMALE; GOUT; GOUT SUPPRESSANTS; HEMATOLOGIC DISEASES; HUMANS; INSURANCE, HEALTH, REIMBURSEMENT; MALE; MIDDLE AGED; PREVALENCE; RENAL INSUFFICIENCY; YOUNG ADULT;

EID: 84871574167     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1002/phar.1125     Document Type: Article

References (34)

1. Lascaratos J. 'Arthritis' in Byzantium (AD 324-1453): unknown information from non-medical literary sources. Ann Rheum Dis 1995;54:951-7
2. Schlesinger N, Schumacher R, Catton M, Maxwell L. Colchicine for acute gout. Cochrane Database Syst Rev 2006;4: CD006190
3. Wilbur K, Makowsky M. Colchicine myotoxicity: case reports and literature review. Pharmacotherapy 2004;24:1784-92 (Pubitemid 39582826)
4. Ducloux D, Schuller V, Bresson-Vautrin C, Chalopin JM. Colchicine myopathy in renal transplant recipients on colchicine Nephrol Dial Transplant 1997;12:2389-92 (Pubitemid 27474624)
5. Alayli G, Cengiz K, Canturk F, et al. Acute myopathy in a patient with concomitant use of pravastatin and colchicine Ann Pharmacother 2005;39:1358-61 (Pubitemid 40943195)
6. Caglar K, Odabasi Z, Safali M, et al. Colchicine-induced myopathy with myotonia in a patient with chronic renal failure Clin Neurol Neurosurg 2003;105:274-6 (Pubitemid 37040789)
7. Hsu WC, Chen WH, Chang MT, Chiu HC. Colchicineinduced acute myopathy in a patient with concomitant use of simvastatin. Clin Neuropharmacol 2002;25:266-8
8. Francis L, Bonilla E, Soforo E, et al. Fatal toxic myopathy attributed to propofol, methylprednisolone, and cyclosporine after prior exposure to colchicine and simvastatin. Clin Rheumatol 2008;27:129-31 (Pubitemid 350182692)
9. Chattopadhyay I, Shetty HGM, Routledge PA, Jeffery J. Colchicine induced rhabdomyolysis. Postgrad Med J 2001;77:191-2 (Pubitemid 32205064)
10. Baker SK, Goodwin S, Sur M, Tarnopolsky MA. Cytoskeletal myotoxicity from simvastatin and colchicine. Muscle Nerve 2004;30:799-802 (Pubitemid 39601297)
11. Atmaca H, Sayarlioglu H, Kulah E, et al. Rhabdomyolysis associated with gemfibrozil-colchicine therapy. Ann Pharmacother 2002;36:1719-21 (Pubitemid 35265608)
12. Atasoyu EM, Evrenkaya TR, Solmazgul E. Possible colchicine rhabdomyolysis in a fluvastatin-treated patient. Ann Pharmacother 2005;39:1368-9 (Pubitemid 40943201)
13. Justiniano M, Dod S, Espinoza LR. Rapid onset of muscle weakness (rhabdomyolysis) associated with the combined use of simvastatin and colchicine. J Clin Rheumatol 2007;13:266-8 (Pubitemid 47549164)
14. Tufan A, Dede DS, Cavus S, et al. Rhabdomyolysis in a patient treated with colchicine and atorvastatin. Ann Pharmacother 2006;40:1466-9 (Pubitemid 44204982)
15. Hung IFN, Wi AKL, Cheng VCC, et al. Fatal interaction between clarithromycin and colchicine in patients with renal insufficiency: a retrospective study. Clin Infect Dis 2005;41:291-300
16. Dixon AJ, Wall GC. Probable colchicine-induced neutropenia not related to intentional overdose. Ann Pharmacother 2001;35:192-5 (Pubitemid 32127129)
17. Lee KY, Kim DY, Chang JY, Bang D. Two cases of acute leucopenia induced by colchicine with concurrent immunosuppressants use in Behcet's disease. Yonsei Med J 2008;49:171-3 (Pubitemid 351513663)
18. Yoon KH. Colchicine induced toxicity and pancytopenia at usual doses and treatment with granulocyte colony-stimulating factor [letter]. J Rheumatol 2001;28:1199-200 (Pubitemid 32422618)
19. Altman A, Szyper-Kravitz M, Shoenfeld Y. Colchicine-induced rhabdomyolysis. Clin Rheumatol 2007;26:2197-9 (Pubitemid 350120371)
20. Boomershine KH. Colchicine-induced rhabdomyolysis. Ann Pharmacother 2002;36:824-6 (Pubitemid 34517412)
21. British Society for Haematology. Guidelines for the diagnosis and management of acquired aplastic anaemia. Br J Haematol 2003;123:782-801
22. Terkeltaub RA. Colchicine update 2008. Semin Arthritis Rheum 2009;38:411-9
23. Montseny JJ, Meyrier A, Gherardi RK. Colchicine toxicity in patients with chronic renal failure. Nephrol Dial Transplant 1996;11:2055-8 (Pubitemid 26345473)
24. Eleftheriou G, Bacis G, Fiocchi R, Seastiano R. Colchicineinduced toxicity in heart transplant patient with chronic renal failure. Clin Toxicol 2008;46:827-30
25. Guven AG, Bahat E, Akman S, et al. Late diagnosis of severe colchicine intoxication. Pediatrics 2002;109:971-3 (Pubitemid 34493371)
26. Ar Scientific Inc. Colcrys (colchicine) package insert. Philadelphia, PA; 2009
27. Miller MA, Hung YM, Haler C, et al. Colchicine-related death presenting as an unknown case of multiple organ failure. J Emerg Med 2005;28:445-8 (Pubitemid 40523694)
28. FDA Alert. Information for healthcare professionals: new safety information for colchicine. July 30, 2009. Available from http://www.fda.gov/ Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ DrugSafetyInformationfor-HeathcareProfessionals/ucm174315.htm. Accessed September 18, 2012
29. Indiana University School of Medicine. Division of Clinical Pharmacology. P450 Drug Interaction Table. Available from http://medicine.iupui.edu/ clinpharm/DDIs/table.aspx. Accessed October 28, 2009
30. Niel E, Scherrmann JM. Colchicine today. Joint Bone Spine 2006;73:672-8 (Pubitemid 44932240)
31. Schulz KF, Grimes DA. Case-control studies: research in reverse. Lancet 2002;359:431-4 (Pubitemid 34158958)
32. Bergstralh EJ, Kosanke JL. Computerized matching of controls Section of Biostatistics Technical Report 56. Rochester, MN: Mayo Foundation; 1995
33. Clark DO, Von Korff M, Saunders K, et al. A chronic disease score with empirically derived weights. Med Care 1995;33: 783-95
34. Bonnel RA, Villalba ML, Karwoski CB, Beitz J. Deaths associated with inappropriate intravenous colchicine administration J Emerg Med 2002;22:385-7 (Pubitemid 34756312)