Efficacy and safety of collagenase clostridium histolyticum injection for dupuytren contracture: Short-term results from 2 open-label studies

Journal of Hand Surgery

Volumn 38, Issue 1, 2013, Pages 2-11

  Witthaut, Jörg ^a,b,c,d,e,f   Jones, Graeme ^a,b,c,d,e,f   Skrepnik, Nebojsa ^a,b,c,d,e,f   Kushner, Harvey ^a,b,c,d,e,f   Houston, Anthony ^a,b,c,d,e,f   Lindau, Tommy R ^a,b,c,d,e,f  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF TASMANIA   (Australia)

^c Tucson Orthopaedic Research Center   (United States)

^d Auxilium Pharmaceuticals Inc   (United States)

^e Caboolture Clinical Research Centre   (Australia)

^f ROYAL DERBY HOSPITAL   (United Kingdom)

Author keywords

Collagenase clostridium histolyticum; Dupuytren contracture; fixed flexion; nonsurgical; open label

Indexed keywords

CLOSTRIDIOPEPTIDASE A;

ADULT; AGED; ARTICLE; DRUG EFFICACY; DRUG SAFETY; DUPUYTREN CONTRACTURE; FEMALE; HUMAN; INJECTION SITE REACTION; LEG THROMBOSIS; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; PROXIMAL INTERPHALANGEAL JOINT; RANGE OF MOTION; RECURRENT DISEASE; TENDINITIS; TENDON RUPTURE;

ADULT; AGED; AGED, 80 AND OVER; CLOSTRIDIUM HISTOLYTICUM; DUPUYTREN CONTRACTURE; FEMALE; HUMANS; INJECTIONS, INTRALESIONAL; MALE; MICROBIAL COLLAGENASE; MIDDLE AGED; PATIENT SATISFACTION; RANGE OF MOTION, ARTICULAR; RETREATMENT; TREATMENT OUTCOME;

EID: 84871570391     PISSN: 03635023     EISSN: 15316564     Source Type: Journal    
DOI: 10.1016/j.jhsa.2012.10.008     Document Type: Article

References (30)

1. G.M. Rayan Dupuytren's disease: anatomy, pathology, presentation, and treatment J Bone Joint Surg Am 89 1 2007 189 198
2. R.B. Shaw Jr, A.K. Chong, A. Zhang, V.R. Hentz, J. Chang Dupuytren's disease: history, diagnosis, and treatment Plast Reconstr Surg 120 3 2007 44e 54e
3. M. Melling, D. Karimian-Teherani, S. Mostler, M. Behnam, G. Sobal, E.J. Menzel Changes of biochemical and biomechanical properties in Dupuytren disease Arch Pathol Lab Med 124 9 2000 1275 1281
4. A. Thomas, A. Bayat The emerging role of Clostridium histolyticum collagenase in the treatment of Dupuytren disease Ther Clin Risk Manag 6 2010 557 572
5. D.B. DiBenedetti, D. Nguyen, L. Zografos, R. Ziemiecki, X. Zhou Prevalence, incidence, and treatments of Dupuytren's disease in the United States: results from a population-based study Hand (N Y) 6 2 2011 149 158
6. D. Brickley-Parsons, M.J. Glimcher, R.J. Smith, R. Albin, J.P. Adams Biochemical changes in the collagen of the palmar fascia in patients with Dupuytren's disease J Bone Joint Surg Am 63 5 1981 787 797
7. K. Denkler Surgical complications associated with fasciectomy for Dupuytren's disease: a 20-year review of the English literature Eplasty 10 2010 116 133
8. S.M. Crean, R.A. Gerber, M.P. Hellio Le Graverand, D.M. Boyd, J.C. Cappelleri The efficacy and safety of fasciectomy and fasciotomy for Dupuytren's contracture in European patients: a structured review of published studies J Hand Surg Eur 36 5 2011 396 407
9. N. Betz, O.J. Ott, B. Adamietz, R. Sauer, R. Fietkau, L. Keilholz Radiotherapy in early-stage Dupuytren's contracture: long-term results after 13 years Strahlenther Onkol 186 2 2010 82 90
10. Xiaflex (collagenase clostridium histolyticum) [prescribing information] October 2010 Auxilium Pharmaceuticals, Inc. Malvern (PA)
11. Summary of product characteristics: Xiapex 0.9 mg powder and solvent for solution for injection [prescribing information] March 14, 2011 Pfizer Limited Kent, UK
12. K.A. Mookhtiar, H.E. Van Wart Clostridium histolyticum collagenases: a new look at some old enzymes Matrix Suppl 1 1992 116 126
13. O. Matsushita, A. Okabe Clostridial hydrolytic enzymes degrading extracellular components Toxicon 39 11 2001 1769 1780
14. S.K. Mallya, K.A. Mookhtiar, H.E. Van Wart Kinetics of hydrolysis of type I, II, and III collagens by the class I and II Clostridium histolyticum collagenases J Protein Chem 11 1 1992 99 107
15. M.F. French, A. Bhown, H.E. Van Wart Identification of Clostridium histolyticum collagenase hyperreactive sites in type I, II, and III collagens: lack of correlation with local triple helical stability J Protein Chem 11 1 1992 83 97
16. H.E. Van Wart, D.R. Steinbrink Complementary substrate specificities of class I and class II collagenases from Clostridium histolyticum Biochemistry 24 23 1985 6520 6526
17. M.A. Badalamente, L.C. Hurst Efficacy and safety of injectable mixed collagenase subtypes in the treatment of Dupuytren's contracture J Hand Surg Am 32 6 2007 767 774
18. O. Matsushita, T. Koide, R. Kobayashi, K. Nagata, A. Okabe Substrate recognition by the collagen-binding domain of Clostridium histolyticum class I collagenase J Biol Chem 276 12 2001 8761 8770
19. M.F. French, K.A. Mookhtiar, H.E. Van Wart Limited proteolysis of type I collagen at hyperreactive sites by class I and II Clostridium histolyticum collagenases: complementary digestion patterns Biochemistry 26 3 1987 681 687
20. S. Miyoshi, H. Nakazawa, K. Kawata, K. Tomochika, K. Tobe, S. Shinoda Characterization of the hemorrhagic reaction caused by Vibrio vulnificus metalloprotease, a member of the thermolysin family Infect Immun 66 10 1998 4851 4855
21. B. Trueb, P. Bornstein Characterization of the precursor form of type VI collagen J Biol Chem 259 13 1984 8597 8604
22. L.C. Hurst, M.A. Badalamente, V.R. Hentz, R.N. Hotchkiss, F.T. Kaplan, R.A. Meals Injectable collagenase clostridium histolyticum for Dupuytren's contracture N Engl J Med 361 10 2009 968 979
23. D. Gilpin, S. Coleman, S. Hall, A. Houston, J. Karrasch, N. Jones Injectable collagenase Clostridium histolyticum: a new nonsurgical treatment for Dupuytren's disease J Hand Surg Am 35 12 2010 2027 2038
24. M.A. Badalamente, L.C. Hurst Enzyme injection as nonsurgical treatment of Dupuytren's disease J Hand Surg Am 25 4 2000 629 636
25. M.A. Badalamente, L.C. Hurst, V.R. Hentz Collagen as a clinical target: nonoperative treatment of Dupuytren's disease J Hand Surg Am 27 5 2002 788 798
26. A.J. Watt, C.M. Curtain, V.R. Hentz Collagenase injection as nonsurgical treatment of Dupuytren's disease: 8-year follow-up J Hand Surg Am 35 4 2010 534 539
27. A.L. van Rijssen, F.S. Gerbrandy, H. ter Linden, H. Klip, P.M. Werker A comparison of the direct outcomes of percutaneous needle fasciotomy and limited fasciectomy for Dupuytren's disease: a 6-week follow-up study J Hand Surg Am 31 5 2006 717 725
28. A. Misra, A. Jain, R. Ghazanfar, T. Johnston, J. Nanchahal Predicting the outcome of surgery for the proximal interphalangeal joint in Dupuytren's disease J Hand Surg Am 32 2 2007 240 245
29. J.J. Dias, J. Braybrooke Dupuytren's contracture: an audit of the outcomes of surgery J Hand Surg Br 31 5 2006 514 521
30. N.W. Bulstrode, B. Jemec, P.J. Smith The complications of Dupuytren's contracture surgery J Hand Surg Am 30 5 2005 1021 1025