A logical molecular circuit for programmable and autonomous regulation of protein activity using DNA aptamer-protein interactions

Journal of the American Chemical Society

Volumn 134, Issue 51, 2012, Pages 20797-20804

  Han, Da ^b   Zhu, Zhi ^a,c   Wu, Cuichen ^b   Peng, Lu ^b   Zhou, Leiji ^b   Gulbakan, Basri ^b   Zhu, Guizhi ^a,b   Williams, Kathryn R ^b   Tan, Weihong ^a,b  

^a HUNAN UNIVERSITY   (China)

^b University of Florida   (United States)

^c XIAMEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AUTONOMOUS REGULATION; BIOLOGICAL ENGINEERING; BIOLOGICAL MOLECULE; CELL-FREE; DISPLACEMENT REACTIONS; DNA HYBRIDIZATION; DNA-PROTEIN INTERACTION; ELECTRICAL CIRCUIT; IN-VITRO; IN-VIVO; LOGICAL CIRCUIT; MOLECULAR CIRCUITS; NANO-DEVICES; NEW DESIGN; PERSONALIZED MEDICINES; PROOF OF PRINCIPLES; PROTEIN ACTIVITY; THERAPEUTIC STRATEGY; THRESHOLD CONCENTRATIONS; THRESHOLD CONTROL;

COAGULATION; DNA; ELECTRICAL ENGINEERING; ELECTROMECHANICAL DEVICES; ENZYMES; GENE EXPRESSION; LOGIC CIRCUITS; SUBSTITUTION REACTIONS;

PROTEINS;

APTAMER; BLOOD CLOTTING INHIBITOR; THROMBIN;

ARTICLE; FLUORESCENCE RESONANCE ENERGY TRANSFER; MOLECULAR ELECTRONICS; PROTEIN DNA INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

APTAMERS, NUCLEOTIDE; BLOOD COAGULATION; COMPUTERS, MOLECULAR; HUMANS; THROMBIN;

EID: 84871566239     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja310428s     Document Type: Article

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