High expression of FER tyrosine kinase predicts poor prognosis in clear cell renal cell carcinoma

Oncology Letters

Volumn 5, Issue 2, 2013, Pages 473-478

  Wei, Can ^a,b,c   Wu, Song ^b,c   Li, Xianxin ^a,b,c   Wang, Yadong ^b,c   Ren, Rui ^b,c   Lai, Yongqing ^b   Ye, Jiongxian ^a,b  

^a THE UNIVERSITY OF HONG KONG SHENZHEN HOSPITAL   (China)

^b PEKING UNIVERSITY SHENZHEN HOSPITAL   (China)

^c ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Clear cell renal cell carcinoma; FER; Metastasis; Prognosis; Tumorigenesis

Indexed keywords

MESSENGER RNA; PROTEIN KINASE FER;

ADULT; AGED; ARTICLE; CANCER CLASSIFICATION; CANCER GRADING; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER RISK; CANCER STAGING; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; LYMPH NODE; MAJOR CLINICAL STUDY; MALE; METASTASIS; OVERALL SURVIVAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; STAINING; TUMOR VOLUME;

EID: 84871554520     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2012.1032     Document Type: Article

References (23)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin 61: 69-90, 2011.
2. Zbar B, Klausner R and Linehan WM: Studying cancer families to identify kidney cancer genes. Annu Rev Med 54: 217-233, 2003.
3. Wei X, Zhou L, Hu L and Huang Y: Tanshinone IIA arrests cell cycle and induces apoptosis in 786-O human renal cell carcinoma cells. Oncol Lett 3: 1144-1148, 2012.
4. Chong PK, Lee H, Kong JW, Loh MC, Wong CH and Lim YP: Phosphoproteomics, oncogenic signaling and cancer research. Proteomics 8: 4370-4382, 2008.
5. Greer P: Closing in on the biological functions of Fps/Fes and Fer. Nat Rev Mol Cell Biol 3: 278-289, 2002.
6. Tsujita K, Suetsugu S, Sasaki N, Furutani M, Oikawa T and Takenawa T: Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis. J Cell Biol 172: 269-279, 2006.
7. Pasder P, Salem Y, Yaffe E, Shpungin S and Nir U: FER as a novel target for cancer therapy. Drugs Fut 32: 61-70, 2007.
8. Li H, Ren Z, Kang X, Zhang L, Li X, Wang Y, Xue T, Shen Y and Liu Y: Identification of tyrosine-phosphorylated proteins associated with metastasis and functional analysis of FER in human hepatocellular carcinoma cells. BMC Cancer 9: 366, 2009.
9. Fuhrman SA, Lasky LC and Limas C: Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 6: 655-663, 1982.
10. Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2-[Delta][Delta] CT method. Methods 25: 402-408, 2001.
11. Schrader A, Sevinc S, Olbert P, Hegele A, Varga Z and HofmannR: Gender-specific characteristics and survival of renal cell carcinoma. Urologe A 47: 1184-1186, 2008.
12. Lane BR, Babineau D, Kattan MW, Novick AC, Gill IS, ZhouM, Weight CJ and Campbell SC: A preoperative prognostic nomogram for solid enhancing renal tumors 7 cm or less amenable to partial nephrectomy. J Urology 178: 429-434, 2007.
13. Tamaskar I, Choueiri TK, Sercia L, Rini B, Bukowski R and ZhouM: Differential expression of caveolin-1 in renal neoplasms. Cancer 110: 776-782, 2007.
14. Paulson R, Jackson J, Immergluck K and Bishop JM: The DFer gene of Drosophila melanogaster encodes two membrane-associated proteins that can both transform vertebrate cells. Oncogene 14: 641-652, 1997.
15. Letwin K, Yee SP and Pawson T: Novel protein-tyrosine kinase cDNAs related to fps/fes and eph cloned using anti-phosphotyrosine antibody. Oncogene 3: 621-627, 1988.
16. Piedra J, Miravet S, Castaño J, Pálmer HG, Heisterkamp N, García de Herreros A and Duñach M: p120 Catenin-associated Fer and Fyn tyrosine kinases regulate β-catenin Tyr-142 phosphorylation and β-catenin-α-catenin Interaction. Mol Cell Biol23: 2287-2297, 2003.
17. Xu G, Craig AWB, Greer P, Miller M, Anastasiadis PZ, Lilien J and Balsamo J: Continuous association of cadherin with β-catenin requires the non-receptor tyrosine-kinase Fer. J Cell Sci 117: 3207-3219, 2004.
18. Daly RJ: Cortactin signalling and dynamic actin networks. Biochem J 382: 13-25, 2004.
19. El Sayegh TY, Arora PD, Laschinger CA, Lee W, Morrison C, Overall CM, Kapus A and McCulloch CA: Cortactin associates with N-cadherin adhesions and mediates intercellular adhesion strengthening in fibroblasts. J Cell Sci 117: 5117-5131, 2004.
20. Lu HY, Mao WM, Cheng QY, Chen B, Cai JF, Wang XJ, Wang Z and Xie FJ: Mutation status of epidermal growth factor receptor and clinical features of patients with combined small cell lung cancer who received surgical treatment. Oncol Lett 3: 1288-1292, 2012.
21. Ben-Dor I, Bern O, Tennenbaum T and Nir U: Cell cycle-dependent nuclear accumulation of the p94fer tyrosine kinase is regulated by its NH2 terminus and is affected by kinase domain integrity and ATP binding. Cell Growth Differ 10: 113-129, 1999.
22. Pasder O, Shpungin S, Salem Y, Makovsky A, Vilchick S, Michaeli S, Malovani H and Nir U: Downregulation of Fer induces PP1 activation and cell-cycle arrest in malignant cells. Oncogene 25: 4194-4206, 2006.
23. Levi F, Ferlay J, Galeone C, Lucchini F, Negri E, Boyle P and LaVecchia C: The changing pattern of kidney cancer incidence and mortality in Europe. BJU Int 101: 949-958, 2008.