Physiological roles of N-acetylglucosaminyltransferase (GnT-V) in mice

BMB Reports

Volumn 45, Issue 10, 2012, Pages 554-559

  Miyoshi, Eiji ^a   Terao, Mika ^a   Kamada, Yoshihiro ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

EGF R; EMT; GnT V; NASH; Oligosaccharide

Indexed keywords

ACTIN; ALPHA 1,6 MANNOSYLGLYCOPROTEIN BETA 1,6 N ACETYLGLUCOSAMINYLTRANSFERASE; ALPHA-1,6-MANNOSYLGLYCOPROTEIN BETA 1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE; EPIDERMAL GROWTH FACTOR RECEPTOR; N ACETYLGLUCOSAMINYLTRANSFERASE;

ANIMAL; ENZYMOLOGY; EPITHELIAL MESENCHYMAL TRANSITION; GENETICS; LIVER; LIVER CIRRHOSIS; METABOLISM; PATHOLOGY; SHORT SURVEY; SIGNAL TRANSDUCTION; SKIN;

ACTINS; ANIMALS; EPITHELIAL-MESENCHYMAL TRANSITION; LIVER; LIVER CIRRHOSIS; N-ACETYLGLUCOSAMINYLTRANSFERASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; SKIN;

MUS; MUS MUSCULUS;

EID: 84871456370     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2012.45.10.190     Document Type: Short Survey

References (33)

1. Hart, G. W. and Copeland, R. J. (2010) Glycomics hits the big time. Cell 143, 672-676.
2. Taniguchi, N., Miyoshi, E., Ko, J. H., Ikeda, Y. and Ihara, Y. (1999) Implication of N-acetylglucosaminyltransferases III and V in cancer: gene regulation and signaling mechanism. Biochim. Biophys. Acta. 1455, 287-300.
3. Lau, K. S. and Dennis, J. W. (2008) N-Glycans in cancer progression. Glycobiology 18, 750-760.
4. Dennis, J. W., Laferte, S., Waghorne, C., Breitman, M. L. and Kerbel, R. S. (1987) Beta 1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis. Science 236, 582-585.
5. Shoreibah, M., Perng, G. S., Adler, B., Weinstein, J., Basu, R., Cupples, R., Wen, D., Browne, J. K., Buckhaults, P., Fregien, N. and Pierce, M. (1993) Isolation, characterization, and expression of a cDNA encoding N-acetylglucosaminyltransferase V. J. Biol. Chem. 268, 15381-15385.
6. Saito, H., Nishikawa, A., Gu, J., Ihara, Y., Soejima, H., Wada, Y., Sekiya, C., Niikawa, N. and Taniguchi, N. (1994) cDNA cloning and chromosomal mapping of human N-acetylglucosaminyltransferase V+. Biochem. Biophys. Res. Commun. 198, 318-327.
7. Partridge, E. A., Le Roy, C., Di Guglielmo, G. M., Pawling, J., Cheung, P., Granovsky, M., Nabi, I. R., Wrana, J. L. and Dennis, J. W. (2004) Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis. Science 306, 120-124.
8. Guo, H. B., Lee, I., Kamar, M. and Pierce, M. (2003) N-acetylglucosaminyltransferase V expression levels regulate cadherin-associated homotypic cell-cell adhesion and intracellular signaling pathways. J. Biol. Chem. 278, 52412-52424.
9. Ihara, S., Miyoshi, E., Ko, J. H., Murata, K., Nakahara, S., Honke, K., Dickson, R. B., Lin, C. Y. and Taniguchi, N. (2002) Prometastatic effect of N-acetylglucosaminyltransferase V is due to modification and stabilization of active matriptase by adding beta 1-6 GlcNAc branching. J. Biol. Chem. 277, 16960-16967.
10. Granovsky, M., Fata, J., Pawling, J., Muller, W. J., Khokha, R. and Dennis, J. W. (2000) Suppression of tumor growth and metastasis in Mgat5-deficient mice. Nat. Med. 6, 306-312.
11. Zeisberg, M. and Neilson, E. G. (2009) Biomarkers for epithelial- mesenchymal transitions. J. Clin. Invest. 119, 1429-1437.
12. Yan, C., Grimm, W. A., Garner, W. L., Qin, L., Travis, T., Tan, N. and Han, Y. P. (2010) Epithelial to mesenchymal transition in human skin wound healing is induced by tumor necrosis factor-alpha through bone morphogenic protein- 2. Am. J. Pathol. 176, 2247-2258.
13. Kalluri, R. and Neilson, E. G. (2003) Epithelial-mesenchymal transition and its implications for fibrosis. J. Clin. Invest. 112, 1776-1784.
14. Desmouliere, A. (1995) Factors influencing myofibroblast differentiation during wound healing and fibrosis. Cell Biol. Int. 19, 471-476.
15. Demetriou, M., Nabi, I. R., Coppolino, M., Dedhar, S. and Dennis, J. W. (1995) Reduced contact-inhibition andsubstratum adhesion in epithelial cells expressing GlcNAc-transferase V. J. Cell Biol. 130, 383-392.
16. Terao, M., Ishikawa, A., Nakahara, S., Kimura, A., Kato, A., Moriwaki, K., Kamada, Y., Murota, H., Taniguchi, N., Katayama, I. and Miyoshi, E. (2011) Enhanced epithelial- mesenchymal transition-like phenotype in N-acetylglucosaminyltransferase V transgenic mouse skin promotes wound healing. J. Biol. Chem. 286, 28303-28311.
17. Miyoshi, E., Nishikawa, A., Ihara, Y., Gu, J., Sugiyama, T., Hayashi, N., Fusamoto, H., Kamada, T. and Taniguchi, N. (1993) N-acetylglucosaminyltransferase III and V messenger RNA levels in LEC rats during hepatocarcinogenesis. Cancer Res. 53, 3899-3902.
18. Miyoshi, E., Ihara, Y., Nishikawa, A., Saito, H., Uozumi, N., Hayashi, N., Fusamoto, H., Kamada, T. and Taniguchi, N. (1995) Gene expression of N-acetylglucosaminyltransferases III and V: a possible implication for liver regeneration. Hepatology 22, 1847-1855.
19. Pastore, S., Mascia, F., Mariani, V. and Girolomoni, G. (2008) The epidermal growth factor receptor system in skin repair and inflammation. J. Invest. Dermatol. 128, 1365-1374.
20. Schneider, M. R., Werner, S., Paus, R. and Wolf, E. (2008) Beyond wavy hairs: the epidermal growth factor receptor and its ligands in skin biology and pathology. Am. J. Pathol. 173, 14-24.
21. Yoshida, A., Kanno, H., Watabe, D., Akasaka, T. and Sawai, T. (2008) The role of heparin-binding EGF-like growth factor and amphiregulin in the epidermal proliferation of psoriasis in cooperation with TNFalpha. Arch. Dermatol. Res. 300, 37-45.
22. Kimura, A., Terao, M., Kato, A., Hanafusa, T., Murota, H., Katayama, I. and Miyoshi, E. (2012) Upregulation of Nacetylglucosaminyltransferase- V by heparin-binding EGFlike growth factor induces keratinocyte proliferation and epidermal hyperplasia. Exp. Dermatol. 21, 515-519.
23. Ihara, Y., Yoshimura, M., Miyoshi, E., Nishikawa, A., Sultan, A. S., Toyosawa, S., Ohnishi, A., Suzuki, M., Yamamura, K., Ijuhin, N. and Taniguchi, N. (1998) Ectopic expression of N-acetylglucosaminyltransferase III in transgenic hepatocytes disrupts apolipoprotein B secretion and induces aberrant cellular morphology with lipid storage. Proc. Natl. Acad. Sci. U.S.A. 95, 2526-2530.
24. Wang, W., Li, W., Ikeda, Y., Miyagawa, J. I., Taniguchi, M., Miyoshi, E., Sheng, Y., Ekuni, A., Ko, J. H., Yamamoto, Y., Sugimoto, T., Yamashita, S., Matsuzawa, Y., Grabowski, G. A., Honke, K. and Taniguchi, N. (2001) Ectopic expression of alpha1,6 fucosyltransferase in mice causes steatosis in the liver and kidney accompanied by a modification of lysosomal acid lipase. Glycobiology 11, 165-174.
25. Ford, E. S., Giles, W. H. and Dietz, W. H. (2002) Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 287, 356-359.
26. Bugianesi, E., Leone, N., Vanni, E., Marchesini, G., Brunello, F., Carucci, P., Musso, A., De Paolis, P., Capussotti, L., Salizzoni, M. and Rizzetto, M. (2002) Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology 123, 134-140.
27. Matsuzawa, N., Takamura, T., Kurita, S., Misu, H., Ota, T., Ando, H., Yokoyama, M., Honda, M., Zen, Y., Nakanuma, Y., Miyamoto, K. and Kaneko, S. (2007) Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet. Hepatology 46, 1392-1403.
28. Kamada, Y., Mori, K., Matsumoto, H., Kiso, S., Yoshida, Y., Shinzaki, S., Hiramatsu, N., Ishii, M., Moriwaki, K., Kawada, N., Takehara, T. and Miyoshi, E. (2012) NAcetylglucosaminyltransferase V regulates TGF-beta response in hepatic stellate cells and the progression of steatohepatitis. Glycobiology 22, 778-787.
29. Friedman, S. L. (2008) Mechanisms of hepatic fibrogenesis. Gastroenterology 134, 1655-1669.
30. Hui, A. Y., Dannenberg, A. J., Sung, J. J., Subbaramaiah, K., Du, B., Olinga, P. and Friedman, S. L. (2004) Prostaglandin E2 inhibits transforming growth factor beta 1-mediated induction of collagen alpha 1(I) in hepatic stellate cells. J. Hepatol. 41, 251-258.
31. Ioffe, E., Liu, Y. and Stanley, P. (1996) Essential role for complex N-glycans in forming an organized layer of bronchial epithelium. Proc. Natl. Acad. Sci. U.S.A. 93, 11041-11046.
32. Shinzaki, S., Iijima, H., Fujii, H., Kuroki, E., Tatsunaka, N., Inoue, T., Nakajima, S., Egawa, S., Kanto, T., Tsujii, M., Morii, E., Takeishi, S., Asano, M., Takehara, T., Hayashi, N. and Miyoshi, E. (2012) Altered oligosaccharide structures reduce colitis induction in mice defective in beta-1,4-galactosyltransferase. Gastroenterology 142, 1172-1182.
33. Gao, C., Maeno, T., Ota, F., Ueno, M., Korekane, H., Takamatsu, S., Shirato, K., Matsumoto, A., Kobayashi, S., Yoshida, K., Kitazume, S., Ohtsubo, K., Betsuyaku, T. and Taniguchi, N. (2012) Sensitivity of heterozygous alpha1,6- fucosyltransferase knock-out mice to cigarette smoke-induced emphysema: implication of aberrant transforming growth factor-beta signaling and matrix metalloproteinase gene expression. J. Biol. Chem. 287, 16699-16708.