Acute ApoA-I Milano administration induces plaque regression and stabilisation in the long term

Thrombosis and Haemostasis

Volumn 108, Issue 6, 2012, Pages 1246-1248

  Giannarelli, Chiara ^a   Cimmino, Giovanni ^a   Ibanez, Borja ^a,b   Chiesa, Giulia ^c   Garcia Prieto, Jaime ^a   Santos Gallego, Carlos G ^a   Alique Aguilar, Matilde ^a   Fuster, Valentin ^a,b   Sirtori, Cesare ^c   Badimon, Juan J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ETC 216; LIPID; MONOCYTE CHEMOTACTIC PROTEIN 1; PLACEBO; THROMBOPLASTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ATHEROSCLEROTIC PLAQUE; CONTROLLED STUDY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LETTER; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; REMISSION; WESTERN BLOTTING;

ANIMALS; AORTA, ABDOMINAL; APOLIPOPROTEIN A-I; GENETIC VARIATION; HUMANS; PLAQUE, ATHEROSCLEROTIC; RABBITS; RECOMBINANT PROTEINS;

EID: 84871447778     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH12-08-0556     Document Type: Letter

References (6)

1. Sirtori CR, Calabresi L, Franceschini G, et al. Cardiovascular status of carriers of the apolipoprotein A-I(Milano) mutant: the Limone sul Garda study. Circulation 2001; 103: 1949-1954.
2. Ibanez B, Vilahur G, Cimmino G, et al. Rapid change in plaque size, composition, and molecular footprint after recombinant apolipoprotein A-I Milano (ETC-216) administration: magnetic resonance imaging study in an experimental model of atherosclerosis. J Am Coll Cardiol 2008; 51: 1104-1109.
3. Nissen SE, Tsunoda T, Tuzcu EM, et al. Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial. J Am Med Assoc 2003; 290: 2292-2300.
4. Cimmino G, Ibanez B, Vilahur G, et al. Up-regulation of reverse cholesterol transport key players and rescue from global inflammation by ApoAI(Milano). J Cell Mol Med 2009; 13: 3226-3235.
5. Choi BG, Vilahur G, Cardoso L, et al. Ovariectomy increases vascular calcification via the OPG/ RANKL cytokine signalling pathway. Eur J Clin Invest 2008; 38: 211-217.
6. Chiesa G, Monteggia E, Marchesi M, et al. Recombinant apolipoprotein A-I(Milano) infusion into rabbit carotid artery rapidly removes lipid from fatty streaks. Circ Res 2002; 90: 974-980.