Leukotrienes Are Upregulated and Associated with Human T-Lymphotropic Virus Type 1 (HTLV-1)-Associated Neuroinflammatory Disease

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Trindade, Bruno Caetano ^a,b   Sorgi, Carlos Artério ^a   Nicolete, Larissa Deadame de Figueiredo ^c   Malta, Tathiane Maistro ^c   Pinto, Mariana Tomazini ^c   Takayanagui, Osvaldo Massaiti ^a   Covas, Dimas Tadeu ^a,c   Filho, Olindo Assis Martins ^b   Kashima, Simone ^c   Faccioli, Lúcia Helena ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c Centro Regional de Hemoterapia de Ribeirão Preto   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; LEUKOTRIENE B4; LEUKOTRIENE C4; LEUKOTRIENE DERIVATIVE; LEUKOTRIENE RECEPTOR; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; PEPTIDOLEUKOTRIENE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL CULTURE; CONTROLLED STUDY; CORRELATIONAL STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS INFECTION; MEDIATOR RELEASE; NERVOUS SYSTEM INFLAMMATION; NEUROPATHOLOGY; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; SPASTIC PARAPLEGIA; SPINAL CORD DISEASE; UPREGULATION; VIRUS CELL INTERACTION; VIRUS LOAD; VIRUS VIRULENCE;

ADULT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CHEMOKINES; FEMALE; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; LEUKOCYTES, MONONUCLEAR; LEUKOTRIENES; MALE; MIDDLE AGED; PARAPARESIS, TROPICAL SPASTIC; PROVIRUSES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, LEUKOTRIENE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; VIRAL LOAD;

HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 84871439894     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051873     Document Type: Article

References (50)

1. Watanabe T, (1997) HTLV-1-associated diseases. Int J Hematol 66: 257-278.
2. Gout O, Baulac M, Gessain M, Semah F, Saal F, et al. (1990) Rapid development of myelopathy after HTLV-1 infection acquired by transfusion during cardiac transplantation. N Engl J Med 322: 383-388.
3. Verdonck K, Gonzalez E, Van Dooren S, Vandamme AM, Vanham G, et al. (2007) Human T-lymphotropic virus 1: recent knowledge about an ancient infection. Lancet Infect Dis 7: 266-281.
4. Cooper SA, van der Loeff MS, Taylor GP, (2009) The neurology of HTLV-1 infection. Pract Neurol 9: 16-26.
5. Umehara F, Osame M (2003) Histological analysis of HAM/TSP pathogenesis. In: ugamira K, Uchiyame T, Masao M, Kannagi M, eds. Two decades of adult Tcell leukaemia and HTLV-1 research. Tokyo, Japan: Scientific Societies Press, 141-148.
6. Carvalho EM, Bacellar O, Porto AF, Braga S, Galvao-Castro B, et al. (2001) Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type-I-infected blood donors. J Acquir Immune Defic Syndr 27: 1-6.
7. Santos SB, Porto AF, Muniz AL, de Jesus AR, Magalhães E, et al. (2004) Exacerbated inflammatory cellular immune response characteristics of HAM/TSP is observed in a large proportion of HTLV-I asymptomatic carriers. BMC Infect Dis 4: 7.
8. Matsuzaki T, Nakagawa M, Nagai M, Usuku K, Higuchi I, et al. (2001) HTLV-I proviral load correlates with progression of motor disability in HAM/TSP: analysis of 239 HAM/TSP patients including 64 patients followed up for 10 years. J Neurovirol 7: 228-234.
9. Takenouchi N, Yamano Y, Usuku K, Osame M, Izumo S, (2003) Usefulness of proviral load measurement for monitoring of disease activity in individual patients with human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis. J Neurovirol 9: 29-35.
10. Olindo S, Lézin A, Cabre P, Merle H, Saint-Vil M, et al. (2005) HTLV-1 proviral load in peripheral blood mononuclear cells quantified in 100 HAM/TSP patients: a marker of disease progression. J Neurol Sci 237: 53-59.
11. Peters-Golden M, Henderson WR Jr, (2007) Leukotrienes. N Engl J Med 357: 1841-1854.
12. Okunishi K, Peters-Golden M, (2011) Leukotrienes and airway inflammation. Biochim Biophys Acta 1810: 1096-1102.
13. Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, et al. (2003) International union of pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors. Pharmacol Rev 55: 195-227.
14. Flamand N, Mancuso P, Serezani CH, Brock TG, (2007) Leukotrienes: mediators that have been typecast as villains. Cell Mol Life Sci 64: 2657-2670.
15. Medeiros AI, Sá-Nunes A, Soares EG, Peres CM, Silva CL, et al. (2004) Blockade of endogenous leukotrienes exacerbates pulmonary histoplasmosis. Infect Immun 72: 1637-1644.
16. Peres CM, de Paula L, Medeiros AI, Sorgi CA, Soares EG, et al. (2007) Inhibition of leukotriene biosynthesis abrogates the host control of Mycobacterium tuberculosis. Microbes Infect 9: 483-489.
17. Gaudreault E, Gosselin J, (2008) Leukotriene B4 induces release of antimicrobial peptides in lungs of virally infected mice. J Immunol 180: 6211-6221.
18. Medeiros AI, Sá-Nunes A, Turato WM, Secatto A, Frantz FG, et al. (2008) Leukotrienes are potent adjuvant during fungal infection: effects on memory T cells. J Immunol 181: 8544-8551.
19. Machado ER, Ueta MT, Lourenço EV, Anibal FF, Sorgi CA, et al. (2005) Leukotrienes play a role in the control of parasite burden in murine strongyloidiasis. J Immunol 175: 3892-3899.
20. Peres-Buzalaf C, de Paula L, Frantz FG, Soares EM, Medeiros AI, et al. (2011) Control of experimental pulmonary tuberculosis depends more on immunostimulatory leukotrienes than on the absence of immunosuppressive prostaglandins. Prostaglandins Leukot Essent Fatty Acids 85: 75-81.
21. Ahmadzadeh N, Shingu M, Nobunaga M, Tawara T, (1991) Relationship between leukotriene B4 and immunological parameters in rheumatoid synovial fluids. Inflammation 15: 497-503.
22. Capra V, Thompson MD, Sala A, Cole DE, Folco G, et al. (2007) Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends. Med Res Rev 27: 469-527.
23. Neu I, Mallinger J, Wildfeuer A, Mehlber L, (1992) Leukotrienes in the cerebrospinal fluid of multiple sclerosis patients. Acta Neurol Scand 86: 586-587.
24. Matsuo M, Hamasaki Y, Masuyama T, Ohta M, Miyazaki S, (1996) Leukotriene B4 and C4 in cerebrospinal fluid from children with meningitis and febrile seizures. Pediatr Neurol 14: 121-124.
25. Froldi M, Castagna A, Parma M, Piona A, Tedeschi A, et al. (1992) Mediator release in cerebrospinal fluid of human immunodeficiency virus-positive patients with central nervous system involvement. J Neuroimmunol 38: 155-161.
26. Yoshikawa K, Palumbo S, Toscano CD, Bosetti F, (2011) Inhibition of 5-lipoxygenase activity in mice during cuprizone-induced demyelination attenuates neuroinflammation, motor dysfunction and axonal damage. Prostaglandins Leukot Essent Fatty Acids 85: 43-52.
27. Gonçalves DU, Proietti FA, Ribas JG, Araújo MG, Pinheiro SR, et al. (2010) Epidemiology, treatment, and prevention of human T-cell leukemia virus type 1-associated diseases. Clin Microbiol Rev 23: 577-589.
28. Best I, Adaui V, Verdonck K, González E, Tipismana M, et al. (2006) Proviral load and immune markers associated with human T-lymphotropic virus type 1 (HTLV-1)- ssociated myelopathy/tropical spastic paraparesis (HAM/TSP) in Peru. Clinical and Experimental Immunology 146: 226-233.
29. de Souza JG, da Fonseca FG, Martins ML, Martins CP, de Carvalho LD, et al. (2011) Anti-Tax antibody levels in asymptomatic carriers, oligosymptomatic carriers, patients with rheumatologic disease or with HAM/TSP do not correlate with HTLV-1 proviral load. J Clin Virol 50: 13-18.
30. Lewis RA, Austen KF, (1984) The biologically active leukotrienes. Biosynthesis, metabolism, receptors, functions, and pharmacology. J Clin Invest 73: 889-897.
31. Claesson HE, Odlander B, Jakobsson PJ, (1992) Leukotriene B4 in the immune system. Int J Immunopharmacol 14: 441-449.
32. Moriuchi M, Inoue H, Moriuchi H, (2001) Reciprocal interactions between human T-lymphotropic virus type 1 and prostaglandins: implications for viral transmission. J Virol 75: 192-198.
33. Flamand L, Tremblay MJ, Borgeat P, (2007) Leukotriene B4 triggers the in vitro and in vivo release of potent antimicrobial agents. J Immunol 178: 8036-8045.
34. Flamand L, Borgeat P, Lalonde R, Gosselin J, (2004) Release of anti-HIV mediators after administration of leukotriene B4 to humans. J Infect Dis 189: 2001-2009.
35. Pouliot M, McDonald PP, Khamzina L, Borgeat P, McColl SR, (1994) Granulocyte-macrophage colony-stimulating factor enhances 5-lipoxygenase levels in human polymorphonuclear leukocytes. J Immunol 152: 851-858.
36. Nassar GM, Montero A, Fukunaga M, Badr KF, (1997) Contrasting effects of proinflammatory and T-helper lymphocyte subset-2 cytokines on the 5-lipoxygenase pathway in monocytes. Kidney Int 51: 1520-1528.
37. Wang L, Du C, Lv J, Wei W, Cui Y, et al. (2011) Antiasthmatic drugs targeting the cysteinyl leukotriene receptor 1 alleviate central nervous system inflammatory cell infiltration and pathogenesis of experimental autoimmune encephalomyelitis. J Immunol 187: 2336-2345.
38. Okubo M, Yamanaka H, Kobayashi K, Noguchi K, (2010) Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain. Glia. 58: 599-610.
39. Kihara Y, Yokomizo T, Kunita A, Morishita Y, Fukayama M, et al. (2010) The leukotriene B4 receptor, BLT1, is required for the induction of experimental autoimmune encephalomyelitis. Biochem Biophys Res Commun 394: 673-678.
40. Wang L, Du C, Lv J, Wei W, Cui Y, et al. (2011) Antiasthmatic drugs targeting the cysteinyl leukotriene receptor 1 alleviate central nervous system inflammatory cell infiltration and pathogenesis of experimental autoimmune encephalomyelitis. J Immunol 187: 2336-2345.
41. Guerreiro JB, Santos SB, Morgan DJ, Porto AF, Muniz AL, et al. (2006) Levels of serum chemokines discriminate clinical myelopathy associated with human T lymphotropic virus type 1 (HTLV-1)/tropical spastic paraparesis (HAM/TSP) disease from HTLV-1 carrier state. Clin Exp Immunol 145: 296-301.
42. Toulza F, Nosaka K, Tanaka Y, Schioppa T, Balkwill F, et al. (2010) Human T-lymphotropic virus type 1-induced CC chemokine ligand 22 maintains a high frequency of functional FoxP3+ regulatory T cells. J Immunol 185: 183-189.
43. Keating SM, Golub ET, Nowicki M, Young M, Anastos K, et al. (2011) The effect of HIV infection and HAART on inflammatory biomarkers in a population-based cohort of women. AIDS 25: 1823-1832.
44. Cannas A, Calvo L, Chiacchio T, Cuzzi G, Vanini V, et al. (2010) IP-10 detection in urine is associated with lung diseases. BMC Infect Dis 10: 333-340.
45. Kabeer BS, Raja A, Raman B, Thangaraj S, Leportier M, et al. (2011) IP-10 response to RD1 antigens might be a useful biomarker for monitoring tuberculosis therapy. BMC Infect Dis 11: 135-143.
46. Izumo S, (2010) Neuropathology of HTLV-1-associated myelopathy (HAM/TSP). Neuropathology 30: 480-485.
47. Ichiyama T, Hasegawa M, Ueno Y, Makata H, Matsubara T, et al. (2005) Cysteinyl leukotrienes induce monocyte chemoattractant protein 1 in human monocytes/macrophages. Clin Exp Allergy 35: 1214-1219.
48. Coffey MJ, Phare SM, Cinti S, Peters-Golden M, Kazanjian PH, (1999) Granulocyte-macrophage colony-stimulating factor upregulates reduced 5-lipoxygenase metabolism in peripheral blood monocytes and neutrophils in acquired immunodeficiency syndrome. Blood 94: 3897-3905.
49. Haddad R, Ciliao A, Rocha-Junior MC, Azevedo R, Pombo-de-Oliveira MS, et al. (2011) HLA-G 14-bp insertion/deletion polymorphism is a risk factor for HTLV-1 infection. AIDS Res Hum Retroviruses 27: 283-8.
50. Luiza-Silva M, Campi-Azevedo AC, Batista MA, Martins MA, Avelar RS, et al. (2011) Cytokine signatures of innate and adaptive immunity in 17DD yellow fever vaccinated children and its association with the level of neutralizing antibody. J Infect Dis 204: 873-883.