Cardiac Conduction Block at Multiple Levels Caused by Arsenic Trioxide Therapy

Canadian Journal of Cardiology

Volumn 29, Issue 1, 2013, Pages 130.e5-130.e6

  Kathirgamanathan, Kala ^a   Angaran, Paul ^a   Lazo Langner, Alejandro ^a   Gula, Lorne J ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARSENIC TRIOXIDE; CYTARABINE; DAUNORUBICIN; DIMERCAPROL; FLUDARABINE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RETINOIC ACID;

ADULT; ARTICLE; ATRIOVENTRICULAR BLOCK; CASE REPORT; CHELATION THERAPY; DRUG WITHDRAWAL; FEMALE; HEART CONDUCTION; HEART RIGHT BUNDLE BRANCH BLOCK; HUMAN; PROMYELOCYTIC LEUKEMIA; RARE DISEASE; TREATMENT DURATION;

EID: 84871438795     PISSN: 0828282X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cjca.2012.04.004     Document Type: Article

References (5)

1. Barbey J.T., Soignet S. Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia. Ann Intern Med 2001, 135:842-843.
2. Barbey J.T., Pezzullo J.C., Soignet S.L. Effect of arsenic trioxide on QT interval in patients with advanced malignancies. J Clin Oncol 2003, 21:3609-3615.
3. Huang C.H., Chen W.J., Wu C.C., Chen Y.C., Lee Y.T. Complete atrioventricular block after arsenic trioxide treatment in an acute promyelocytic leukemic patient. Pacing Clin Electrophysiol 1999, 22(Part 1):965-967.
4. Unnikrishnan D., Dutcher J.P., Varshneya N., et al. Torsades de pointes in 3 patients with leukemia treated with arsenic trioxide. Blood 2001, 97:1514-1516.
5. Westervelt P., Brown R.A., Adkins D.R., et al. Sudden death among patients with acute promyelocytic leukemia treated with arsenic trioxide. Blood 2001, 98:266-271.