Twenty-five milligrams of clomiphene citrate presents positive effect on treatment of male testosterone deficiency - A prospective study

International Braz J Urol

Volumn 38, Issue 4, 2012, Pages 512-518

  Da Ros, Carlos Teodósio ^a   Averbeck, Márcio Augusto ^a  

^a Centro de Andrologia e Urologia   (Brazil)

Author keywords

Clomiphene; Hypogonadism; Treatment outcome

Indexed keywords

ANTIESTROGEN; CLOMIFENE; TESTOSTERONE;

ADULT; AGE; AGED; ARTICLE; BLOOD; EPIDEMIOLOGY; HUMAN; HYPOGONADISM; LUMINESCENCE; MALE; METABOLISM; MIDDLE AGED; QUALITY OF LIFE; TIME; TREATMENT OUTCOME;

ADULT; AGE FACTORS; AGED; CLOMIPHENE; EPIDEMIOLOGIC METHODS; ESTROGEN ANTAGONISTS; HUMANS; HYPOGONADISM; LUMINESCENCE; MALE; MIDDLE AGED; QUALITY OF LIFE; TESTOSTERONE; TIME FACTORS; TREATMENT OUTCOME;

EID: 84871429269     PISSN: 16775538     EISSN: 16776119     Source Type: Journal    
DOI: 10.1590/S1677-55382012000400011     Document Type: Article

References (21)

1. Shabsigh A, Kang Y, Shabsign R, Gonzalez M, Liberson G, Fisch H, et al.: Clomiphene citrate effects on testosterone/estrogen ratio in male hypogonadism. J Sex Med. 2005; 2: 716-21.
2. Travison TG, Morley JE, Araujo AB, O'Donnell AB, McKinlay JB: The relationship between libido and testosterone levels in aging men. J Clin Endocrinol Metab. 2006; 91: 2509-13.
3. Neaves WB, Johnson L, Porter JC, Parker CR Jr, Petty CS: Leydig cell numbers, daily sperm production, and serum gonadotropin levels in aging men. J Clin Endocrinol Metab. 1984; 59: 756-63.
4. Taylor F, Levine L: Clomiphene citrate and testosterone gel replacement therapy for male hypogonadism: efficacy and treatment cost. J Sex Med. 2010; 7(1 Pt 1): 269-76.
5. Hermann M, Untergasser G, Rumpold H, Berger P: Aging of the male reproductive system. Exp Gerontol. 2000; 35: 1267-79.
6. Morales A, Heaton JP, Carson CC 3rd: Andropause: a misnomer for a true clinical entity. J Urol. 2000; 163: 705-12.
7. Ioannidou-Kadis S, Wright PJ, Neely RD, Quinton R: Complete reversal of adult-onset isolated hypogonadotropic hypogonadism with clomiphene citrate. Fertil Steril. 2006; 86: 1513.e5-9.
8. Goldstein SR, Siddhanti S, Ciaccia AV, Plouffe L Jr.: A pharmacological review of selective oestrogen receptor modulators. Hum Reprod Update. 2000; 6: 212-24.
9. Tenover JS, Bremner WJ: The effects of normal aging on the response of the pituitary-gonadal axis to chronic clomiphene administration in men. J Androl. 1991; 12: 258-63.
10. Hussein A, Ozgok Y, Ross L, Niederberger C: Clomiphene administration for cases of nonobstructive azoospermia: a multicenter study. J Androl. 2005; 26: 787-91; discussion 792-3.
11. Whitten SJ, Nangia AK, Kolettis PN: Select patients with hypogonadotropic hypogonadism may respond to treatment with clomiphene citrate. Fertil Steril. 2006; 86: 1664-8.
12. Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR; Baltimore Longitudinal Study of Aging: Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab. 2001; 86: 724-31.
13. Black AM, Day AG, Morales A: The reliability of clinical and biochemical assessment in symptomatic late-onset hypogonadism: can a case be made for a 3-month therapeutic trial? BJU Int. 2004; 94: 1066-70.
14. Wu FC, Tajar A, Beynon JM, Pye SR, Silman AJ, Finn JD, et al.: Identification of late-onset hypogonadism in middleaged and elderly men. N Engl J Med. 2010; 363: 123-35.
15. Wang C, Nieschlag E, Swerdloff R, Behre HM, Hellstrom WJ, Gooren LJ, et al.: Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA and ASA recommendations. Eur J Endocrinol. 2008; 159: 507-14.
16. Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS, et al.: Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2006; 91: 1995-2010. Erratum in: J Clin Endocrinol Metab. 2006; 91: 2688.
17. Granata AR, Rochira V, Lerchl A, Marrama P, Carani C: Relationship between sleep-related erections and testosterone levels in men. J Androl. 1997; 18: 522-7.
18. Tan RS, Vasudevan D: Use of clomiphene citrate to reverse premature andropause secondary to steroid abuse. Fertil Steril. 2003; 79: 203-5.
19. Guay AT, Bansal S, Heatley GJ: Effect of raising endogenous testosterone levels in impotent men with secondary hypogonadism: double blind placebo-controlled trial with clomiphene citrate. J Clin Endocrinol Metab. 1995; 80: 3546-52.
20. Burge MR, Lanzi RA, Skarda ST, Eaton RP: Idiopathic hypogonadotropic hypogonadism in a male runner is reversed by clomiphene citrate. Fertil Steril. 1997; 67: 783-5.
21. Guay AT, Jacobson J, Perez JB, Hodge MB, Velasquez E: Clomiphene increases free testosterone levels in men with both secondary hypogonadism and erectile dysfunction: who does and does not benefit? Int J Impot Res. 2003; 15: 156-65.