-
1
-
-
27844567142
-
Distinct sets of genetic alterations in melanoma
-
Curtin JA, Fridlyand J, Kageshita T et al (2005) Distinct sets of genetic alterations in melanoma. N Engl J Med 353:2135-2147
-
(2005)
N Engl J Med
, vol.353
, pp. 2135-2147
-
-
Curtin, J.A.1
Fridlyand, J.2
Kageshita, T.3
-
2
-
-
55949083407
-
Anti-cytotoxic t-lymphocyte antigen-4 antibody: The first in an emerging class of immunomodulatory antibodies for cancer treatment
-
Fong L, Small EJ (2008) Anti-cytotoxic T-lymphocyte antigen-4 antibody: the first in an emerging class of immunomodulatory antibodies for cancer treatment. J Clin Oncol 26:5275-5283
-
(2008)
J Clin Oncol
, vol.26
, pp. 5275-5283
-
-
Fong, L.1
Small, E.J.2
-
3
-
-
74949143594
-
Final version of 2009 ajcc melanoma staging and classification
-
Balch CM, Gershenwald JE, Soong SJ et al (2009) Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol 27:6199-6206
-
(2009)
J Clin Oncol
, vol.27
, pp. 6199-6206
-
-
Balch, C.M.1
Gershenwald, J.E.2
Soong, S.J.3
-
4
-
-
77950576363
-
Interferon alpha adjuvant therapy in patients with high-risk melanoma: A systematic review and meta-Analysis
-
Mocellin S, Pasquali S, Rossi CR et al (2010) Interferon alpha adjuvant therapy in patients with high-risk melanoma: a systematic review and meta-Analysis. J Natl Cancer Inst 102:493-501
-
(2010)
J Natl Cancer Inst
, vol.102
, pp. 493-501
-
-
Mocellin, S.1
Pasquali, S.2
Rossi, C.R.3
-
5
-
-
0030030347
-
Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma. The eastern cooperative oncology group trial est 1684
-
Kirkwood JM, Strawderman MH, Ernstorff MS et al (1996) Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma. The Eastern Cooperative Oncology Group Trial EST 1684. J Clin Oncol 14:7-17
-
(1996)
J Clin Oncol
, vol.14
, pp. 7-17
-
-
Kirkwood, J.M.1
Strawderman, M.H.2
Ernstorff, M.S.3
-
6
-
-
84655168007
-
Ulceration and stage are predictive of interferon efficacy in melanoma: Results of the phase iii adjuvant trials eortc 18952 and eortc 18991
-
Eggermont A, Suciu S, Testori A et al (2012) Ulceration and stage are predictive of interferon efficacy in melanoma: results of the phase III adjuvant trials EORTC 18952 and EORTC 18991. Eur J Cancer 48:218-225
-
(2012)
Eur J Cancer
, vol.48
, pp. 218-225
-
-
Eggermont, A.1
Suciu, S.2
Testori, A.3
-
8
-
-
1642554821
-
Final results of the eortc 18871/dkg 80-1 randomised phase iii trial:rifn-A2b versus rifn-g versus iscador m1 versus observation after surgery in melanoma patients with either high-risk primary (thickness >3 mm) or regional lymph node metastasis
-
Kleeberg UR, Suciu S, Bröcker EB et al (2004) Final results of the EORTC 18871/DKG 80-1 randomised phase III trial:rIFN-A2b versus rIFN-g versus ISCADOR M1 versus observation after surgery in melanoma patients with either high-risk primary (thickness >3 mm) or regional lymph node metastasis. Eur J Cancer 40:390-402
-
(2004)
Eur J Cancer
, vol.40
, pp. 390-402
-
-
Kleeberg, U.R.1
Suciu, S.2
Bröcker, E.B.3
-
9
-
-
53549105257
-
Adjuvant treatment with vindesine in comparison to observation alone in patients with metastasized melanoma after complete metastasectomy: A randomized multicenter trial of the german dermatologic cooperative oncology group
-
Eigentler TK, Radny R, Hauschild A et al (2008) Adjuvant treatment with vindesine in comparison to observation alone in patients with metastasized melanoma after complete metastasectomy: a randomized multicenter trial of the German Dermatologic Cooperative Oncology Group. Melanoma Res 18:353-358
-
(2008)
Melanoma Res
, vol.18
, pp. 353-358
-
-
Eigentler, T.K.1
Radny, R.2
Hauschild, A.3
-
10
-
-
0019933831
-
A randomized trial of adjuvant chemotherapy and immunotherapy in cutaneous melanoma
-
Veronesi U, Adamus J, Aubert C (1982) A randomized trial of adjuvant chemotherapy and immunotherapy in cutaneous melanoma. N Engl J Med 307:913-916
-
(1982)
N Engl J Med
, vol.307
, pp. 913-916
-
-
Veronesi, U.1
Adamus, J.2
Aubert, C.3
-
11
-
-
18444374405
-
Mutations of the braf gene in human cancer
-
Davies H, Bignell GF, Cox C et al (2002) Mutations of the BRAF gene in human cancer. Nature 417:949-954
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.F.2
Cox, C.3
-
12
-
-
77956030786
-
Inhibition of mutated, activated braf in metastatic melanoma
-
Flaherty KT, Puzanov I, Kim KB et al (2010) Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 363:809-819
-
(2010)
N Engl J Med
, vol.363
, pp. 809-819
-
-
Flaherty, K.T.1
Puzanov, I.2
Kim, K.B.3
-
13
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with braf v600e mutation
-
Chapman PB, Hauschild A, Robert C et al (2011) Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 364:2507-2516
-
(2011)
N Engl J Med
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
-
14
-
-
84865068182
-
Updated overall survival (os) results for brim-3, a phase iii randomized, open-label, multicenter trial comparing braf inhibitor vemurafenib with dacarbazine in previously untreated patients with braf v600e-mutated melanoma
-
Chapman PB, Hausschild A, Robert C et al (2012) Updated overall survival (OS) results for BRIM-3, a phase III randomized, open-label, multicenter trial comparing BRAF inhibitor vemurafenib with dacarbazine in previously untreated patients with BRAF V600E-mutated melanoma. J Clin Oncol 30(Suppl15):8502
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.15
, pp. 8502
-
-
Chapman, P.B.1
Hausschild, A.2
Robert, C.3
-
15
-
-
84864285704
-
Dabrafenib in braf-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial
-
Hauschild A, Grob JJ, Demidov LV et al (2012) Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet 380:358-365
-
(2012)
Lancet
, vol.380
, pp. 358-365
-
-
Hauschild, A.1
Grob, J.J.2
Demidov, L.V.3
-
16
-
-
84863116743
-
Survival in braf v600 -mutant advanced melanoma treated with vemurafenib
-
Sosman JA, Kim KB, Schuchter L et al (2012) Survival in BRAF V600 -mutant advanced melanoma treated with vemurafenib. N Engl J Med 366:707-714
-
(2012)
N Engl J Med
, vol.366
, pp. 707-714
-
-
Sosman, J.A.1
Kim, K.B.2
Schuchter, L.3
-
17
-
-
84863673204
-
Improved survival with mek inhibition in braf-mutated melanoma
-
Flaherty KT, Robert C, Hersey P et al (2012) Improved survival with MEK inhibition in BRAF-mutated melanoma. N Engl J Med 367:107-114
-
(2012)
N Engl J Med
, vol.367
, pp. 107-114
-
-
Flaherty, K.T.1
Robert, C.2
Hersey, P.3
-
18
-
-
84864277515
-
Efficacy and safety of oral mek162 in patients with locally advanced and unresectable or metastatic cutaneous melanoma harbouring brafv600 or nras mutations
-
Ascierto PA, Berking C, Agarwala SS et al (2012) Efficacy and safety of oral MEK162 in patients with locally advanced and unresectable or metastatic cutaneous melanoma harbouring BRAFV600 or NRAS mutations. J Clin Oncol 30(Suppl 15):8511
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL. 15
, pp. 8511
-
-
Ascierto, P.A.1
Berking, C.2
Agarwala, S.S.3
-
19
-
-
72049115498
-
Kit as a therapeutic target in melanoma
-
Garrido MC, Bastian BC (2010) KIT as a therapeutic target in melanoma. J Invest Dermatol 130:20-27
-
(2010)
J Invest Dermatol
, vol.130
, pp. 20-27
-
-
Garrido, M.C.1
Bastian, B.C.2
-
20
-
-
67649909568
-
Results of a phase iii, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage iii or stage iv melanoma
-
Hauschild A, Agarwala SS, Trefzer U et al (2009) Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma. J Clin Oncol 27:2823-2830
-
(2009)
J Clin Oncol
, vol.27
, pp. 2823-2830
-
-
Hauschild, A.1
Agarwala, S.S.2
Trefzer, U.3
-
21
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS, O'Day SJ, McDermott SF et al (2010) Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 363:711-723
-
(2010)
N Engl J Med
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
O'Day, S.J.2
McDermott, S.F.3
-
22
-
-
79959772576
-
Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
-
Robert C, Thomas L, Bondarenko I et al (2011) Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 364:2517-2526
-
(2011)
N Engl J Med
, vol.364
, pp. 2517-2526
-
-
Robert, C.1
Thomas, L.2
Bondarenko, I.3
-
23
-
-
0027524697
-
Randomized phase iii trial of treatment with high-dose interleukin-2 either alone or in combination with interferon-Alfa-2a in patients with advanced melanoma
-
Sparano J, Fisher R, Sunderland M et al (1993) Randomized phase III trial of treatment with high-dose interleukin-2 either alone or in combination with interferon-Alfa-2a in patients with advanced melanoma. J Clin Oncol 11:1969-1977
-
(1993)
J Clin Oncol
, vol.11
, pp. 1969-1977
-
-
Sparano, J.1
Fisher, R.2
Sunderland, M.3
-
24
-
-
34648827914
-
Chemoimmunotherapy versus chemotherapy for metastatic malignant melanoma
-
Sasse AD, Sasse EC, Clark LG et al (2007) Chemoimmunotherapy versus chemotherapy for metastatic malignant melanoma. Cochrane Database Syst Rev (1):CD005413
-
(2007)
Cochrane Database Syst Rev
, Issue.1
-
-
Sasse, A.D.1
Sasse, E.C.2
Clark, L.G.3
-
25
-
-
27244432257
-
Dacarbazine, cisplatin, and interferon-Alfa-2b with or without interleukin-2 in metastatic melanoma: A randomized phase iii trial (18951) of the european organisation for research and treatment of cancer melanoma group
-
Keilholz U, Punt CJA, Gore M et al (2005) Dacarbazine, cisplatin, and interferon-Alfa-2b with or without interleukin-2 in metastatic melanoma: a randomized phase III trial (18951) of the European Organisation for Research and Treatment of Cancer Melanoma Group. J Clin Oncol 23:6747-6755
-
(2005)
J Clin Oncol
, vol.23
, pp. 6747-6755
-
-
Keilholz, U.1
Punt, C.J.A.2
Gore, M.3
-
26
-
-
0347503603
-
Palliative therapy of disseminated malignant melanoma: A systematic review of 41 randomised clinical trials
-
Eigentler TK, Caroli UM, Radny P et al (2003) Palliative therapy of disseminated malignant melanoma: a systematic review of 41 randomised clinical trials. Lancet Oncol 4:748-759
-
(2003)
Lancet Oncol
, vol.4
, pp. 748-759
-
-
Eigentler, T.K.1
Caroli, U.M.2
Radny, P.3
-
27
-
-
84868224906
-
Combined braf and mek inhibition in melanoma with braf v600 mutations
-
[Epub ahead of print]
-
Flaherty KT, Infante JR, Daud A et al (2012) Combined BRAF and MEK Inhibition in melanoma with BRAF V600 mutations. N Engl J Med [Epub ahead of print]
-
N Engl J Med
, vol.2012
-
-
Flaherty, K.T.1
Infante, J.R.2
Daud, A.3
-
28
-
-
7144228601
-
Randomized trial of interferon alpha-2b as adjuvant therapy in resected primary melanoma thicker than 1.5 mm without clinically detectable node metastases
-
Grob JJ, Dreno B, Salmoniere P de la et al (1998) Randomized trial of interferon alpha-2b as adjuvant therapy in resected primary melanoma thicker than 1.5 mm without clinically detectable node metastases. Lancet 351:1905-1910
-
(1998)
Lancet
, vol.351
, pp. 1905-1910
-
-
Grob, J.J.1
Dreno, B.2
Salmoniere P De, La.3
|