Selection and Characterization of a Candidate Therapeutic Bacteriophage That Lyses the Escherichia coli O104:H4 Strain from the 2011 Outbreak in Germany

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Merabishvili, Maia ^a,b,c   de Vos, Daniel ^a   Verbeken, Gilbert ^a   Kropinski, Andrew M ^d,e   Vandenheuvel, Dieter ^f   Lavigne, Rob ^f   Wattiau, Pierre ^g   Mast, Jan ^h   Ragimbeau, Catherine ⁱ   Mossong, Joel ⁱ   Scheres, Jacques ^j,k   Chanishvili, Nina ^b   Vaneechoutte, Mario ^c   Pirnay, Jean Paul ^a  

^a QUEEN ASTRID MILITARY HOSPITAL   (Belgium)

^b George Eliava Institute of Bacteriophage Microbiology and Virology   (Georgia)

^c GHENT UNIVERSITY   (Belgium)

^d PUBLIC HEALTH AGENCY OF CANADA   (Canada)

^e UNIVERSITY OF GUELPH   (Canada)

^f UNIVERSITY OF LEUVEN   (Belgium)

^g VETERINARY AND AGROCHEMICAL RESEARCH CENTRE   (Belgium)

^h Electron Microscopy Unit   (Belgium)

ⁱ LABORATOIRE NATIONAL DE SANTÉ   (Luxembourg)

^j MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^k EUROPEAN CENTRE FOR DISEASE PREVENTION AND CONTROL ECDC   (Sweden)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BACTERIAL STRAIN; BACTERIOLYSIS; BACTERIOPHAGE; CONTROLLED STUDY; EPIDEMIC; ESCHERICHIA COLI; GERMANY; NONHUMAN; NUCLEOTIDE SEQUENCE; VIRAL GENETICS; VIRUS DETECTION; VIRUS IDENTIFICATION; VIRUS ISOLATION; VIRUS MORPHOLOGY;

BACTERIOLYSIS; BACTERIOPHAGES; DISEASE OUTBREAKS; ESCHERICHIA COLI INFECTIONS; GERMANY; HEMOLYTIC-UREMIC SYNDROME; HUMANS; OPEN READING FRAMES; SHIGA-TOXIGENIC ESCHERICHIA COLI;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 84871385638     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052709     Document Type: Article

References (28)

1. Frank C, Werber D, Cramer JP, Askar M, Faber M, et al. (2011) Epidemic profile of Shiga-toxin-producing Escherichia coli O104:H4 outbreak in Germany. N Engl J Med 365: 1771-1780.
2. Casey PG, Hill C, Gahan CG, (2011) E. coli O104:H4: social media and the characterization of an emerging pathogen. Bioeng Bugs 2: 189-193.
3. Bielaszewska M, Mellmann A, Zhang W, Köck R, Fruth A, et al. (2011) Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study. Lancet Infect Dis 11: 671-676.
4. Mellmann A, Harmsen D, Cummings CA, Zentz EB, Leopold SR, et al. (2011) Prospective genomic characterization of the German enterohemorrhagic Escherichia coli O104:H4 outbreak by rapid next generation sequencing technology. PLoS ONE 6: e22751.
5. Altmann M, Spode A, Altmann D, Wadl M, Benzler J, et al. (2011) Timeliness of surveillance during outbreak of Shiga Toxin-producing Escherichia coli infection, Germany, 2011. Emerg Infect Dis 17: 1906-1909.
6. Buchholz U, Bernard H, Werber D, Böhmer MM, Remschmidt C, et al. (2011) German outbreak of Escherichia coli O104:H4 associated with sprouts. N Engl J Med 365: 1763-1770.
7. Michael M, Elliott EJ, Ridley GF, Hodson EM, Craig JC (2009) Interventions for haemolytic uraemic syndrome and thrombotic thrombocytopenic purpura. Cochrane Database Syst Rev CD003595.
8. Kimmitt PT, Harwood CR, Barer MR, (2000) Toxin gene expression by shiga toxin-producing Escherichia coli: the role of antibiotics and the bacterial SOS response. Emerg Infect Dis 6: 458-465.
9. Pirnay JP, Verbeken G, Rose T, Jennes S, Zizi M, et al. (2012) Introducing yesterday's phage therapy in today's medicine. Future Virol 7: 379-390.
10. Faruque SM, Bin Naser I, Islam MJ, Faruque ASG, Ghosh AN, et al. (2005) Seasonal epidemics of cholera inversely correlate with the prevalence of environmental cholera phages. Proc Natl Acad Sci U S A 102: 1702-1707.
11. Bruttin A, Brüssow H, (2005) Human volunteers receiving Escherichia coli phage T4 orally: a safety test of phage therapy. Antimicrob Agents Chemother 49: 2874-2878.
12. Goodridge LD, Bisha B, (2011) Phage-based biocontrol strategies to reduce foodborne pathogens in foods. Bacteriophage 1: 130-137.
13. Muniesa M, Hammerl JA, Hertwig S, Appel B, Brüssow H, (2012) Shiga toxin-producing Escherichia coli O104:H4: a new challenge for microbiology. Appl Environ Microbiol 78: 4065-4073.
14. Maura D, Morello E, du Merle L, Bomme P, Le Bouguénec C, et al. (2011) Intestinal colonization by enteroaggregative Escherichia coli supports long-term bacteriophage replication in mice. Environ Microbiol 14: 1844-1854.
15. Merabishvili M, Pirnay JP, Verbeken G, Chanishvili N, Tediashvili M, et al. (2009) Quality-controlled small-scale production of a well-defined bacteriophage cocktail for use in human clinical trials. PLoS ONE 4: e4944.
16. Kropinski AM, Van den Bossche A, Lavigne R, Noben JP, Babinger P, et al. (2012) Genome and proteome analysis of 7-7-1, a flagellotropic phage infecting Agrobacterium sp H13-3. Virol J 9: 102.
17. Vandersteegen K, Mattheus W, Ceyssens PJ, Bilocq F, De Vos D, et al. (2011) Microbiological and molecular assessment of bacteriophage ISP for the control of Staphylococcus aureus. PLoS ONE 6: e24418.
18. Lukashin AV, Borodovsky M, (1998) GeneMark.hmm: new solutions for gene finding. Nucleic Acids Res 26: 1107-1115.
19. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ, (1990) Basic local alignment search tool. J Mol Biol 215: 403-410.
20. Myers E, Miller W, (1988) Optimal alignments in linear space. CABIOS 4: 11-17.
21. Rice P, Longden I, Bleasby A, (2000) EMBOSS: the European molecular biology open software suite. Trends Genet 16: 276-277.
22. Edgell DR, Gibb EA, Belfort M, (2010) Mobile DNA elements in T4 and related phages. Virology Journal 7: 290.
23. Bezuidt O, Pierneef R, Mncube K, Lima-Mendez G, Reva ON, (2011) Mainstreams of horizontal gene exchange in enterobacteria: consideration of the outbreak of enterohemorrhagic E. coli O104:H4 in Germany in 2011. PLoS ONE 6: e25702.
24. Brüssow H (2012) What is needed for phage therapy to become a reality in Western medicine? Virology [Epub ahead of print].
25. Struelens MJ, Palm D, Takkinen J, (2011) Enteroaggregative, Shiga toxin-producing Escherichia coli O104:H4 outbreak: new microbiological findings boost coordinated investigations by European public health laboratories. Euro Surveill 16: 19890.
26. Friedrich A, (2011) Enterohaemorrhagic Escherichia coli O104:H4: are we prepared now? Euro Surveill 16: 19938.
27. Imberechts H, Wild P, Charlier G, De Greve H, Lintermans P, et al. (1996) Characterization of F18 fimbrial genes fedE and fedF involved in adhesion and length of enterotoxemic Escherichia coli strain 107/86. Microb Pathog 21: 183-192.
28. Arbiol C, Comeau AM, Kutateladze M, Adamia R, Krisch HM, (2010) Mobile regulatory cassettes mediate modular shuffling in T4-type phage genomes. Genome Biol Evol 2: 140-152.