Assessment of functional antibacterial opsonophagocytic antibodies elicited by 13-valent pneumococcal conjugate vaccine administered concomitantly with trivalent influenza vaccine in a randomized clinical trial in adults aged ≥65 years

Vaccine

Volumn 31, Issue 2, 2013, Pages 291-294

  Schwarz, Tino F ^a   Schmoele Thoma, Beate ^b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b PFIZER INC   (United States)

Author keywords

13 Valent pneumococcal conjugate vaccine; Noninferiority; Opsonophagocytic activity; Trivalent inactivated influenza vaccine

Indexed keywords

IMMUNOGLOBULIN G ANTIBODY; INFLUENZA VACCINE; PNEUMOCOCCUS VACCINE;

AGED; ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; ASSAY; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNE RESPONSE; IMMUNOGENICITY; INFLUENZA; INFLUENZA VACCINATION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OPSONOPHAGOCYTIC ACTIVITY ASSAY; PNEUMOCOCCAL INFECTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

AGED; ANTIBODIES, BACTERIAL; DOUBLE-BLIND METHOD; FEMALE; HUMANS; IMMUNIZATION SCHEDULE; IMMUNOGLOBULIN G; INFLUENZA VACCINES; INFLUENZA, HUMAN; MALE; PNEUMOCOCCAL INFECTIONS; PNEUMOCOCCAL VACCINES; SEROTYPING; VACCINES, CONJUGATE;

EID: 84871383879     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2012.10.077     Document Type: Article

References (7)

1. Schwarz T.F., Flamaing J., Rümke H.C., Penzes J., Juergens C., Wenz A., et al. A randomized, double-blind trial to evaluate immunogenicity and safety of 13-valent pneumococcal conjugate vaccine given concomitantly with trivalent influenza vaccine in adults aged ≥65 years. Vaccine 2011, 29:5195-5202.
2. Guckian J.C., Christensen G.D., Fine D.P. The role of opsonins in recovery from experimental pneumococcal pneumonia. J Infect Dis 1980, 142(August (2)):175-190.
3. Cooper D., Yu X., Sidhu M., Nahm M.H., Fernsten P., Jansen K.U. The 13-valent pneumococcal conjugate vaccine (PCV13) elicits cross-functional opsonophagocytic killing responses in humans to Streptococcus pneumoniae serotypes 6C and 7A. Vaccine 2011, 29:7207-7211.
4. Romero-Steiner S., Libutti D., Pais L.B., Dykes J., Anderson P., Whitin J.C., et al. Standardization of an opsonophagocytic assay for the measurement of functional antibody activity against Streptococcus pneumoniae using differentiated HL-60 cells. Clin Diagn Lab Immunol 1997, 4:415-422.
5. Hu B.T., Yu X., Jones T.R., Kirch C., Harris S., Hildreth S.W., et al. Approach to validating an opsonophagocytic assay for Streptococcus pneumoniae. Clin Diagn Lab Immunol 2005, 12:287-295.
6. Chan I.S., Zhang Z. Test-based exact confidence intervals for the difference of two binomial proportions. Biometrics 1999, 55(4):1202-1209.
7. Jackson L.A., Neuzil K.M. Pneumococcal polysaccharide vaccines. Vaccines 2008, Saunders, Elsevier, Philadelphia, PA. 5th ed. S.A. Plotkin, W.A. Orenstein, P.A. Offit (Eds.).