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Volumn 7, Issue 12, 2012, Pages

δEF1 Down-Regulates ER-α Expression and Confers Tamoxifen Resistance in Breast Cancer

Author keywords

[No Author keywords available]

Indexed keywords

DELTA EF1 PROTEIN; E2 BOX PROTEIN; ESTROGEN RECEPTOR ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; TAMOXIFEN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 84871357085     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052380     Document Type: Article
Times cited : (17)

References (42)
  • 1
    • 54849434450 scopus 로고    scopus 로고
    • Current research topics in endocrine therapy for breast cancer
    • Yamashita H, (2008) Current research topics in endocrine therapy for breast cancer. Int J Clin Oncol 13: 380-383.
    • (2008) Int J Clin Oncol , vol.13 , pp. 380-383
    • Yamashita, H.1
  • 2
    • 32944482642 scopus 로고    scopus 로고
    • Novel mechanisms of resistance to endocrine therapy: genomic and nongenomic considerations
    • Gururaj AE, Rayala SK, Vadlamudi RK, Kumar R, (2006) Novel mechanisms of resistance to endocrine therapy: genomic and nongenomic considerations. Clin Cancer Res 12: 1001s-1007s.
    • (2006) Clin Cancer Res , vol.12
    • Gururaj, A.E.1    Rayala, S.K.2    Vadlamudi, R.K.3    Kumar, R.4
  • 3
    • 79551576468 scopus 로고    scopus 로고
    • Mechanisms of endocrine resistance in breast cancer
    • Osborne CK, Schiff R, (2011) Mechanisms of endocrine resistance in breast cancer. Annu Rev Med 62: 233-247.
    • (2011) Annu Rev Med , vol.62 , pp. 233-247
    • Osborne, C.K.1    Schiff, R.2
  • 4
    • 79551604866 scopus 로고    scopus 로고
    • Pharmacogenetics of endocrine therapy for breast cancer
    • Higgins MJ, Stearns V, (2011) Pharmacogenetics of endocrine therapy for breast cancer. Annu Rev Med 62: 281-293.
    • (2011) Annu Rev Med , vol.62 , pp. 281-293
    • Higgins, M.J.1    Stearns, V.2
  • 5
    • 77952397929 scopus 로고    scopus 로고
    • Estrogen receptor mutations and changes in downstream gene expression and signaling
    • Barone I, Brusco L, Fuqua SA, (2010) Estrogen receptor mutations and changes in downstream gene expression and signaling. Clin Cancer Res 16: 2702-2708.
    • (2010) Clin Cancer Res , vol.16 , pp. 2702-2708
    • Barone, I.1    Brusco, L.2    Fuqua, S.A.3
  • 6
    • 12144269500 scopus 로고    scopus 로고
    • Crosstalk between estrogen receptor and growth factor receptor pathways as a cause for endocrine therapy resistance in breast cancer
    • Osborne CK, Shou J, Massarweh S, Schiff R, (2005) Crosstalk between estrogen receptor and growth factor receptor pathways as a cause for endocrine therapy resistance in breast cancer. Clin Cancer Res 11: 865s-870s.
    • (2005) Clin Cancer Res , vol.11
    • Osborne, C.K.1    Shou, J.2    Massarweh, S.3    Schiff, R.4
  • 7
    • 0027383025 scopus 로고
    • Delta-crystallin enhancer binding protein delta EF1 is a zinc finger-homeodomain protein implicated in postgastrulation embryogenesis
    • Funahashi J, Sekido R, Murai K, Kamachi Y, Kondoh H, (1993) Delta-crystallin enhancer binding protein delta EF1 is a zinc finger-homeodomain protein implicated in postgastrulation embryogenesis. Development 119: 433-446.
    • (1993) Development , vol.119 , pp. 433-446
    • Funahashi, J.1    Sekido, R.2    Murai, K.3    Kamachi, Y.4    Kondoh, H.5
  • 8
    • 74049159081 scopus 로고    scopus 로고
    • delta-EF1 is a negative regulator of Ihh in the developing growth plate
    • Bellon E, Luyten FP, Tylzanowski P, (2009) delta-EF1 is a negative regulator of Ihh in the developing growth plate. J Cell Biol 187: 685-699.
    • (2009) J Cell Biol , vol.187 , pp. 685-699
    • Bellon, E.1    Luyten, F.P.2    Tylzanowski, P.3
  • 9
    • 34548695219 scopus 로고    scopus 로고
    • deltaEF1 represses BMP-2-induced differentiation of C2C12 myoblasts into the osteoblast lineage
    • Yang S, Zhao L, Yang J, Chai D, Zhang M, et al. (2007) deltaEF1 represses BMP-2-induced differentiation of C2C12 myoblasts into the osteoblast lineage. J Biomed Sci 14: 663-679.
    • (2007) J Biomed Sci , vol.14 , pp. 663-679
    • Yang, S.1    Zhao, L.2    Yang, J.3    Chai, D.4    Zhang, M.5
  • 10
    • 33745505315 scopus 로고    scopus 로고
    • DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation
    • Nishimura G, Manabe I, Tsushima K, Fujiu K, Oishi Y, et al. (2006) DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation. Dev Cell 11: 93-104.
    • (2006) Dev Cell , vol.11 , pp. 93-104
    • Nishimura, G.1    Manabe, I.2    Tsushima, K.3    Fujiu, K.4    Oishi, Y.5
  • 11
    • 3042796204 scopus 로고    scopus 로고
    • Regulation of collagen type I in vascular smooth muscle cells by competition between Nkx2.5 and deltaEF1/ZEB1
    • Ponticos M, Partridge T, Black CM, Abraham DJ, Bou-Gharios G, (2004) Regulation of collagen type I in vascular smooth muscle cells by competition between Nkx2.5 and deltaEF1/ZEB1. Mol Cell Biol 24: 6151-6161.
    • (2004) Mol Cell Biol , vol.24 , pp. 6151-6161
    • Ponticos, M.1    Partridge, T.2    Black, C.M.3    Abraham, D.J.4    Bou-Gharios, G.5
  • 12
    • 0345307701 scopus 로고    scopus 로고
    • Expression of Zfhep/deltaEF1 protein in palate, neural progenitors, and differentiated neurons
    • Darling DS, Stearman RP, Qi Y, Qiu MS, Feller JP, (2003) Expression of Zfhep/deltaEF1 protein in palate, neural progenitors, and differentiated neurons. Gene Expr Patterns 3: 709-717.
    • (2003) Gene Expr Patterns , vol.3 , pp. 709-717
    • Darling, D.S.1    Stearman, R.P.2    Qi, Y.3    Qiu, M.S.4    Feller, J.P.5
  • 13
    • 0035813173 scopus 로고    scopus 로고
    • delta Ef1 binds to a far upstream sequence of the mouse pro-alpha 1(I) collagen gene and represses its expression in osteoblasts
    • Terraz C, Toman D, Delauche M, Ronco P, Rossert J, (2001) delta Ef1 binds to a far upstream sequence of the mouse pro-alpha 1(I) collagen gene and represses its expression in osteoblasts. J Biol Chem 276: 37011-37019.
    • (2001) J Biol Chem , vol.276 , pp. 37011-37019
    • Terraz, C.1    Toman, D.2    Delauche, M.3    Ronco, P.4    Rossert, J.5
  • 14
    • 0031594268 scopus 로고    scopus 로고
    • DeltaEF1, a zinc finger and homeodomain transcription factor, is required for skeleton patterning in multiple lineages
    • Takagi T, Moribe H, Kondoh H, Higashi Y, (1998) DeltaEF1, a zinc finger and homeodomain transcription factor, is required for skeleton patterning in multiple lineages. Development 12: 21-31.
    • (1998) Development , vol.12 , pp. 21-31
    • Takagi, T.1    Moribe, H.2    Kondoh, H.3    Higashi, Y.4
  • 15
    • 0030906128 scopus 로고    scopus 로고
    • Impairment of T cell development in deltaEF1 mutant mice
    • Higashi Y, Moribe H, Takagi T, Sekido R, Kawakami K, et al. (1997) Impairment of T cell development in deltaEF1 mutant mice. J Exp Med 185: 1467-1479.
    • (1997) J Exp Med , vol.185 , pp. 1467-1479
    • Higashi, Y.1    Moribe, H.2    Takagi, T.3    Sekido, R.4    Kawakami, K.5
  • 16
    • 0025781194 scopus 로고
    • Identification of nuclear factor delta EF1 and its binding site essential for lens-specific activity of the delta 1-crystallin enhancer
    • Funahashi J, Kamachi Y, Goto K, Kondoh H, (1991) Identification of nuclear factor delta EF1 and its binding site essential for lens-specific activity of the delta 1-crystallin enhancer. Nucleic Acids Res 19: 3543-3547.
    • (1991) Nucleic Acids Res , vol.19 , pp. 3543-3547
    • Funahashi, J.1    Kamachi, Y.2    Goto, K.3    Kondoh, H.4
  • 17
    • 79956105716 scopus 로고    scopus 로고
    • CCN6 (WISP3) decreases ZEB1-mediated EMT and invasion by attenuation of IGF-1 receptor signaling in breast cancer
    • Lorenzatti G, Huang W, Pal A, Cabanillas AM, Kleer CG, (2011) CCN6 (WISP3) decreases ZEB1-mediated EMT and invasion by attenuation of IGF-1 receptor signaling in breast cancer. JCell Sci 124: 1752-1758.
    • (2011) JCell Sci , vol.124 , pp. 1752-1758
    • Lorenzatti, G.1    Huang, W.2    Pal, A.3    Cabanillas, A.M.4    Kleer, C.G.5
  • 18
    • 79952489285 scopus 로고    scopus 로고
    • δEF1 promotes osteolytic metastasis of MDA-MB-231 breast cancer cells by regulating MMP-1 expression
    • Hu F, Wang C, Guo S, Sun W, Mi D, et al. (2011) δEF1 promotes osteolytic metastasis of MDA-MB-231 breast cancer cells by regulating MMP-1 expression. Biochim Biophys Acta 1809: 200-210.
    • (2011) Biochim Biophys Acta , vol.1809 , pp. 200-210
    • Hu, F.1    Wang, C.2    Guo, S.3    Sun, W.4    Mi, D.5
  • 19
    • 64149085515 scopus 로고    scopus 로고
    • BMP-6 inhibits microRNA-21 expression in breast cancer through repressing deltaEF1 and AP-1
    • Du J, Yang S, An D, Hu F, Yuan W, et al. (2009) BMP-6 inhibits microRNA-21 expression in breast cancer through repressing deltaEF1 and AP-1. Cell Res 19 487-496.
    • (2009) Cell Res , vol.19 , pp. 487-496
    • Du, J.1    Yang, S.2    An, D.3    Hu, F.4    Yuan, W.5
  • 20
    • 79952698464 scopus 로고    scopus 로고
    • Activated KrasG12D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin
    • Rachagani S, Senapati S, Chakraborty S, Ponnusamy MP, Kumar S, et al. (2011) Activated KrasG12D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin. Br J Cancer 104: 1038-1048.
    • (2011) Br J Cancer , vol.104 , pp. 1038-1048
    • Rachagani, S.1    Senapati, S.2    Chakraborty, S.3    Ponnusamy, M.P.4    Kumar, S.5
  • 21
    • 59449092007 scopus 로고    scopus 로고
    • Delta-crystallin enhancer binding factor 1 controls the epithelial to mesenchymal transition phenotype and resistance to the epidermal growth factor receptor inhibitor erlotinib in human head and neck squamous cell carcinoma lines
    • Haddad Y, Choi W, McConkey DJ, (2009) Delta-crystallin enhancer binding factor 1 controls the epithelial to mesenchymal transition phenotype and resistance to the epidermal growth factor receptor inhibitor erlotinib in human head and neck squamous cell carcinoma lines. Clin Cancer Res 1: 532-542.
    • (2009) Clin Cancer Res , vol.1 , pp. 532-542
    • Haddad, Y.1    Choi, W.2    McConkey, D.J.3
  • 22
    • 33645732687 scopus 로고    scopus 로고
    • The transcription factor ZEB1 is aberrantly expressed in aggressive uterine cancers
    • Spoelstra NS, Manning NG, Higashi Y, Darling D, Singh M, et al. (2006) The transcription factor ZEB1 is aberrantly expressed in aggressive uterine cancers. Cancer Res 66: 3893-3902.
    • (2006) Cancer Res , vol.66 , pp. 3893-3902
    • Spoelstra, N.S.1    Manning, N.G.2    Higashi, Y.3    Darling, D.4    Singh, M.5
  • 23
    • 35548974844 scopus 로고    scopus 로고
    • The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity
    • Aigner K, Dampier B, Descovich L, Mikula M, Sultan A, et al. (2007) The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity. Oncogene 26: 6979-6988.
    • (2007) Oncogene , vol.26 , pp. 6979-6988
    • Aigner, K.1    Dampier, B.2    Descovich, L.3    Mikula, M.4    Sultan, A.5
  • 24
    • 43049103824 scopus 로고    scopus 로고
    • The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
    • Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, et al. (2008) The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 10: 593-601.
    • (2008) Nat Cell Biol , vol.10 , pp. 593-601
    • Gregory, P.A.1    Bert, A.G.2    Paterson, E.L.3    Barry, S.C.4    Tsykin, A.5
  • 25
    • 38849147900 scopus 로고    scopus 로고
    • BMP-6 promotes E-cadherin expression through repressing deltaEF1 in breast cancer cells
    • Yang S, Du J, Wang Z, Yuan W, Qiao Y, et al. (2007) BMP-6 promotes E-cadherin expression through repressing deltaEF1 in breast cancer cells. BMC Cancer 7: 211.
    • (2007) BMC Cancer , vol.7 , pp. 211
    • Yang, S.1    Du, J.2    Wang, Z.3    Yuan, W.4    Qiao, Y.5
  • 26
    • 20144388095 scopus 로고    scopus 로고
    • DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells
    • Eger A, Aigner K, Sonderegger S, Dampier B, Oehler ZS, et al. (2005) DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells. Oncogene 24 2375-2385.
    • (2005) Oncogene , vol.24 , pp. 2375-2385
    • Eger, A.1    Aigner, K.2    Sonderegger, S.3    Dampier, B.4    Oehler, Z.S.5
  • 27
    • 74149093477 scopus 로고    scopus 로고
    • DeltaEF1 promotes breast cancer cell proliferation through down-regulating p21 expression
    • Hu F, Wang C, Du J, Sun W, Yan J, et al. (2010) DeltaEF1 promotes breast cancer cell proliferation through down-regulating p21 expression. Biochim Biophys Acta 1802: 301-312.
    • (2010) Biochim Biophys Acta , vol.1802 , pp. 301-312
    • Hu, F.1    Wang, C.2    Du, J.3    Sun, W.4    Yan, J.5
  • 28
    • 0037072783 scopus 로고    scopus 로고
    • Upstream stimulatory factor (USF) is recruited into a steroid hormone-triggered regulatory circuit by the estrogen-inducible transcription factor delta EF1
    • Dillner NB, Sanders MM, (2002) Upstream stimulatory factor (USF) is recruited into a steroid hormone-triggered regulatory circuit by the estrogen-inducible transcription factor delta EF1. J Biol Chem 277: 33890-33894.
    • (2002) J Biol Chem , vol.277 , pp. 33890-33894
    • Dillner, N.B.1    Sanders, M.M.2
  • 29
    • 0037188818 scopus 로고    scopus 로고
    • The zinc finger/homeodomain protein deltaEF1 mediates estrogen-specific induction of the ovalbumin gene
    • Dillner NB, Sanders MM, (2002) The zinc finger/homeodomain protein deltaEF1 mediates estrogen-specific induction of the ovalbumin gene. Mol Cell Endocrinol 192: 85-91.
    • (2002) Mol Cell Endocrinol , vol.192 , pp. 85-91
    • Dillner, N.B.1    Sanders, M.M.2
  • 30
    • 33846827373 scopus 로고    scopus 로고
    • Endocrine therapy resistance can be associated with high estrogen receptor alpha (ERalpha) expression and reduced ERalpha phosphorylation in breast cancer models
    • Kuske B, Naughton C, Moore K, Macleod KG, Miller WR, et al. (2006) Endocrine therapy resistance can be associated with high estrogen receptor alpha (ERalpha) expression and reduced ERalpha phosphorylation in breast cancer models. Endocr. Relat Cancer 13: 1121-1133.
    • (2006) Endocr. Relat Cancer , vol.13 , pp. 1121-1133
    • Kuske, B.1    Naughton, C.2    Moore, K.3    Macleod, K.G.4    Miller, W.R.5
  • 31
    • 20544469804 scopus 로고    scopus 로고
    • Differential effects of estrogen receptor antagonists on pituitary lactotroph proliferation and prolactin release
    • Kansra S, Yamagata S, Sneade L, Foster L, Ben-Jonathan N, (2005) Differential effects of estrogen receptor antagonists on pituitary lactotroph proliferation and prolactin release. Mol Cell Endocrinol 239: 27-36.
    • (2005) Mol Cell Endocrinol , vol.239 , pp. 27-36
    • Kansra, S.1    Yamagata, S.2    Sneade, L.3    Foster, L.4    Ben-Jonathan, N.5
  • 32
    • 84860390340 scopus 로고    scopus 로고
    • Preclinical modeling of combined phosphatidylinositol-3-kinase inhibition with endocrine therapy for estrogen receptor-positive breast cancer
    • Sanchez CG, Ma CX, Crowder RJ, Guintoli T, Phommaly C, et al. (2011) Preclinical modeling of combined phosphatidylinositol-3-kinase inhibition with endocrine therapy for estrogen receptor-positive breast cancer. Breast Cancer Res 13: R21.
    • (2011) Breast Cancer Res , vol.13
    • Sanchez, C.G.1    Ma, C.X.2    Crowder, R.J.3    Guintoli, T.4    Phommaly, C.5
  • 33
    • 2942544830 scopus 로고    scopus 로고
    • Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer
    • Michalides R, Griekspoor A, Balkenende A, Verwoerd D, et al. (2004) Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer. Cancer Cell 5: 597-605.
    • (2004) Cancer Cell , vol.5 , pp. 597-605
    • Michalides, R.1    Griekspoor, A.2    Balkenende, A.3    Verwoerd, D.4
  • 34
    • 71549124954 scopus 로고    scopus 로고
    • Positive cross-talk between estrogen receptor and NF-kappaB in breast cancer
    • Frasor J, Weaver A, Pradhan M, Dai Y, Miller LD, et al. (2009) Positive cross-talk between estrogen receptor and NF-kappaB in breast cancer. Cancer Res 69: 8918-8925.
    • (2009) Cancer Res , vol.69 , pp. 8918-8925
    • Frasor, J.1    Weaver, A.2    Pradhan, M.3    Dai, Y.4    Miller, L.D.5
  • 35
    • 70249109717 scopus 로고    scopus 로고
    • Repression of ESR1 through actions of estrogen receptor alpha and Sin3A at the proximal promoter
    • Ellison-Zelski SJ, Solodin NM, Alarid ET, (2009) Repression of ESR1 through actions of estrogen receptor alpha and Sin3A at the proximal promoter. Mol Cell Biol 29: 4949-4958.
    • (2009) Mol Cell Biol , vol.29 , pp. 4949-4958
    • Ellison-Zelski, S.J.1    Solodin, N.M.2    Alarid, E.T.3
  • 36
    • 11244296162 scopus 로고    scopus 로고
    • A Mechanisms of tamoxifen resistance
    • Ring A, Dowsett M, (2004) A Mechanisms of tamoxifen resistance. Endocr Relat Cancer 11: 643-658.
    • (2004) Endocr Relat Cancer , vol.11 , pp. 643-658
    • Ring, A.1    Dowsett, M.2
  • 37
    • 77952397929 scopus 로고    scopus 로고
    • Estrogen receptor mutations and changes in downstream gene expression and signaling
    • Barone I, Brusco L, Fuqua SA, (2010) Estrogen receptor mutations and changes in downstream gene expression and signaling. Clin Cancer Res 16: 2702-2708.
    • (2010) Clin Cancer Res , vol.16 , pp. 2702-2708
    • Barone, I.1    Brusco, L.2    Fuqua, S.A.3
  • 38
    • 0032526094 scopus 로고    scopus 로고
    • Mapping of ER gene CpG island methylation-specific polymerase chain reaction
    • Lapidus RG, Nass SJ, Butash KA, Parl FF, Weitzman SA, et al. (1998) Mapping of ER gene CpG island methylation-specific polymerase chain reaction. Cancer Res 58: 2515-2519.
    • (1998) Cancer Res , vol.58 , pp. 2515-2519
    • Lapidus, R.G.1    Nass, S.J.2    Butash, K.A.3    Parl, F.F.4    Weitzman, S.A.5
  • 39
    • 0035477320 scopus 로고    scopus 로고
    • Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells
    • Yang X, Phillips DL, Ferguson AT, Nelson WG, Herman JG, et al. (2001) Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells. Cancer Res 61: 7025-7029.
    • (2001) Cancer Res , vol.61 , pp. 7025-7029
    • Yang, X.1    Phillips, D.L.2    Ferguson, A.T.3    Nelson, W.G.4    Herman, J.G.5
  • 40
    • 84863725383 scopus 로고    scopus 로고
    • Twist contributes to hormone resistance in breast cancer by downregulating estrogen receptor-α
    • Vesuna F, Lisok A, Kimble B, Domek J, Kato Y, et al. (2012) Twist contributes to hormone resistance in breast cancer by downregulating estrogen receptor-α. Oncogene 31: 3223-3234.
    • (2012) Oncogene , vol.31 , pp. 3223-3234
    • Vesuna, F.1    Lisok, A.2    Kimble, B.3    Domek, J.4    Kato, Y.5
  • 41
    • 79952318223 scopus 로고    scopus 로고
    • Down-regulation of FXYD3 is induced by transforming growth factor-β signaling via ZEB1/δEF1 in human mammary epithelial cells
    • Yamamoto H, Mukaisho K, Sugihara H, Hattori T, Asano S, (2011) Down-regulation of FXYD3 is induced by transforming growth factor-β signaling via ZEB1/δEF1 in human mammary epithelial cells. Biol Pharm Bull 34: 324-329.
    • (2011) Biol Pharm Bull , vol.34 , pp. 324-329
    • Yamamoto, H.1    Mukaisho, K.2    Sugihara, H.3    Hattori, T.4    Asano, S.5
  • 42
    • 50649124650 scopus 로고    scopus 로고
    • Estrogen regulates Snail and Slug in the down-regulation of E-cadherin and induces metastatic potential of ovarian cancer cells through estrogen receptor alpha
    • Park SH, Cheung LW, Wong AS, Leung PC, (2008) Estrogen regulates Snail and Slug in the down-regulation of E-cadherin and induces metastatic potential of ovarian cancer cells through estrogen receptor alpha. Mol Endocrinol 22: 2085-2098.
    • (2008) Mol Endocrinol , vol.22 , pp. 2085-2098
    • Park, S.H.1    Cheung, L.W.2    Wong, A.S.3    Leung, P.C.4


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