Regulatory T cell-based immunotherapies in experimental autoimmune myasthenia gravis

Annals of the New York Academy of Sciences

Volumn 1274, Issue 1, 2012, Pages 120-126

  Souroujon, Miriam C ^a,b   Aricha, Revital ^a   Feferman, Tali ^a   Mizrachi, Keren ^a,c   Reuveni, Debby ^a,b   Fuchs, Sara ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b OPEN UNIVERSITY OF ISRAEL   (Israel)

^c BAR ILAN UNIVERSITY   (Israel)

Author keywords

Experimental autoimmune myasthenia gravis; IL 6; Th17 cells

Indexed keywords

INTERLEUKIN 6; NEUTRALIZING ANTIBODY;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL DIFFERENTIATION; CONTROLLED STUDY; EX VIVO STUDY; EXPERIMENTAL AUTOIMMUNE MYASTHENIA GRAVIS; HUMORAL IMMUNITY; IMMUNOTHERAPY; MYASTHENIA GRAVIS; NONHUMAN; PATHOGENESIS; RAT; REGULATORY T LYMPHOCYTE; TARGET CELL; TH17 CELL;

EID: 84871298181     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2012.06844.x     Document Type: Article

References (27)

1. Brunkow, M.E. et al. 2001. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 27: 68-73.
2. + natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol. Rev. 212: 8-27.
3. Buckner, J.H. 2010. Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases. Nat. Rev. Immunol. 10: 849-859.
4. Balandina, A. et al. 2005. Functional defect of regulatory CD4(+)CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis. Blood 105: 735-741.
5. + regulatory T cells and Th17 cells in myasthenia gravis patients. J. Neuroimmunol. 225: 123-131.
6. Fattorossi, A., Battaglia, A., Buzzonetti, A., et al. 2005. Circulating and thymic CD4 CD25 T regulatory cells in myasthenia gravis: effect of immunosuppressive treatment. Immunology 116: 134-141.
7. Sun, Y., Qiao, J., Lu, C.Z., et al. 2004. Increase of circulating CD4+CD25+ T cells in myasthenia gravis patients with stability and thymectomy. Clin. Immunol. 112: 284-289.
8. Sakaguchi, S. et al. 2012. Re-establishing immunological self-tolerance in autoimmune disease. Nat. Med. 18: 54-58.
9. Hsu, W.T. et al. 2006. The role of CD4 CD25 T cells in autoantibody production in murine lupus. Clin. Exp. Immunol. 145: 513-519.
10. Iikuni, N. et al. 2009. Cutting edge: regulatory T cells directly suppress B cells in systemic lupus erythematosus. J. Immunol. 183: 1518-1522.
11. Aricha, R. et al. 2008. Ex vivo generated regulatory T cells modulate experimental autoimmune myasthenia gravis. J. Immunol. 180: 2132-2139.
12. Aricha, R. et al. 2011. Blocking of IL-6 suppresses experimental autoimmune myasthenia gravis. J. Autoimmunity 36: 135-141.
13. Souroujon, M.C. et al. 2010. Development of novel therapies for MG. Autoimmunity 43: 446-460.
14. + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2: 389-400.
15. + immunoregulatory T cells: central players in the arena of peripheral tolerance. Semin. Immunol. 16: 81-88.
16. + T cell subset committed in vivo to suppress antigen-specific T cell responses without additional stimulation. Eur. J. Immunol. 34: 3016-3027.
17. Feng, N.H. et al. 2004. Transplantation tolerance mediated by regulatory T cells in mice. Chin. Med. J. 117: 1184-1189.
18. + cells in the recipient. Int. Immunol. 18: 279-289.
19. Weaver, C.T. & K.M. Murphy. 2007. The central role of the Th17 lineage in regulating the inflammatory/autoimmune axis. Semin. Immunol. 19: 351-352.
20. Korn, T. et al. 2007. Th17 cells: effector T cells with inflammatory properties. Semin. Immunol. 9: 362-371.
21. Ishihara, K. & T. Hirano. 2002. IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev. 13: 357-368.
22. Cohen-Kaminsky, S. et al. 1993. High IL-6 gene expression and production by cultured human thymic epithelial cells from patients with myasthenia gravis. Ann. N. Y. Acad. Sci. 681: 97-99.
23. Endo, S. et al. 2005. Inhibition of IL-6 overproduction by steroid treatment before transsternal thymectomy for myasthenia gravis: does it help stabilize perioperative condition Eur. J. Neurol. 12: 768-773.
24. Van Snick, J. 1990. Interleukin-6: an overview. Annu. Rev. Immunol. 8: 253-278.
25. Chen-Kiang, S. 1995. Regulation of terminal differentiation of human B-cells by IL-6. Curr. Top Microbiol. Immunol. 194: 189-198.
26. Takatsu, K. 1997. Cytokines involved in B-cell differentiation and their sites of action. Proc. Soc. Exp. Biol. Med. 215: 121-133.
27. + regulatory T cells. Proc. Natl. Acad. Sci. USA 105: 18460-18465.