Potential confounds in estimating trial-to-trial correlations between neuronal response and behavior using choice probabilities

Journal of Neurophysiology

Volumn 108, Issue 12, 2012, Pages 3403-3415

  Kang, Incheol ^a   Maunsell, John H R ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Detect probability; Grand choice probability; Psychophysics; Unbalanced sample size; Z score normalization

Indexed keywords

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; ELECTROPHYSIOLOGY; HAPLORHINI; INFORMATION PROCESSING; MALE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; SCORING SYSTEM; STIMULUS RESPONSE; VISUAL STIMULATION;

ANIMALS; CHOICE BEHAVIOR; MACACA MULATTA; MALE; NEURONS; PHOTIC STIMULATION; PROBABILITY; PSYCHOMOTOR PERFORMANCE; RANDOM ALLOCATION; REACTION TIME;

EID: 84871278497     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.00471.2012     Document Type: Article

References (46)

1. Bosking WH, Maunsell JH. Effects of stimulus direction on the correlation between behavior and single units in area MT during a motion detection task. J Neurosci 31: 8230-8238, 2011.
2. Britten KH, Shadlen MN, Newsome WT, Movshon JA. The analysis of visual motion: a comparison of neuronal and psychophysical performance. J Neurosci 12: 4745-4765, 1992.
3. Britten KH, Newsome WT, Shadlen MN, Celebrini S, Movshon JA. A relationship between behavioral choice and the visual responses of neurons in macaque MT. Vis Neurosci 13: 87-100, 1996.
4. Celebrini S, Newsome WT. Neuronal and psychophysical sensitivity to motion signals in extrastriate area MST of the macaque monkey. J Neurosci 14: 4109-4124, 1994.
5. Cohen MR, Maunsell JH. A neuronal population measure of attention predicts behavioral performance on individual trials. J Neurosci 30: 15241-15253, 2010.
6. Cohen MR, Newsome WT. Context-dependent changes in functional circuitry in visual area MT. Neuron 60: 162-173, 2008.
7. Cohen MR, Newsome WT. Estimates of the contribution of single neurons to perception depend on timescale and noise correlation. J Neurosci 29: 6635-6648, 2009.
8. Cook EP, Maunsell JH. Dynamics of neuronal responses in macaque MT and VIP during motion detection. Nat Neurosci 5: 985-994, 2002.
9. Croner LJ, Albright TD. Segmentation by color influences responses of motion-sensitive neurons in the cortical middle temporal visual area. J Neurosci 19: 3935-3951, 1999.
10. de Lafuente V, Romo R. Neuronal correlates of subjective sensory experience. Nat Neurosci 8: 1698-1703, 2005.
11. Dodd JV, Krug K, Cumming BG, Parker AJ. Perceptually bistable threedimensional figures evoke high choice probabilities in cortical area MT. J Neurosci 21: 4809-4821, 2001.
12. Gu Y, DeAngelis GC, Angelaki DE. A functional link between area MSTd and heading perception based on vestibular signals. Nat Neurosci 10: 1038-1047, 2007.
13. Gu Y, Angelaki DE, DeAngelis GC. Neural correlates of multisensory cue integration in macaque MSTd. Nat Neurosci 11: 1201-1210, 2008.
14. Heuer HW, Britten KH. Optic flow signals in extrastriate area MST: comparison of perceptual and neuronal sensitivity. J Neurophysiol 91: 1314-1326, 2004.
15. Herrington TM, Masse NY, Hachmeh KJ, Smith JE, Assad JA, Cook EP. The effect of microsaccades on the correlation between neural activity and behavior in middle temporal, ventral interparietal, and lateral intraparietal areas. J Neurosci 29: 5793-5805, 2009.
16. Hodges JL, Lehmann EL. Basic Concepts of Probability and Statistics. San Francisco, CA: Holden-Day, 1964.
17. Law C, Gold JI. Neural correlates of perceptual learning in a sensory-motor, but not a sensory, cortical area. Nat Neurosci 11: 505-513, 2008.
18. Liu J, Newsome WT. Correlation between speed perception and neural activity in the middle temporal visual area. J Neurosci 25: 711-722, 2005.
19. Macmillan NA, Creelman CD. Detection Theory. Mahwah, NJ: Erlbaum, 2005.
20. Masse NY, Cook EP. The effect of middle temporal spike phase on sensory encoding and correlates with behavior during a motion-detection task. J Neurosci 28: 1343-1355, 2008.
21. Matsumora T, Koida K, Komatsu H. Relationship between color discrimination and neural responses in the inferior temporal cortex of the monkey. J Neurophysiol 100: 3361-3374, 2008.
22. Mruczek RE, Sheinberg DL. Activity of inferior temporal cortical neurons predicts recognition choice behavior and recognition time during visual search. J Neurosci 27: 2825-2836, 2007.
23. Nienborg H, Cumming BG. Macaque V2 neurons, but not V1 neurons, show choice-related activity. J Neurosci 26: 9567-9568, 2006.
24. Nienborg H, Cumming BG. Psychophysically measured task strategy for disparity discrimination is reflected in V2 neurons. Nat Neurosci 10: 1608-1614, 2007.
25. Nienborg H, Cumming BG. Decision-related activity in sensory neurons reflects more than a neuron's causal effect. Nature 459: 89-92, 2009.
26. Nienborg H, Cumming BG. Correlations between the activity of sensory neurons and behavior: how much do they tell us about a neuron's causality? Curr Opin Neurobiol 20: 376-381, 2010.
27. Palmer C, Cheng S, Seidemann E. Linking neuronal and behavioral performance in a reaction-time visual detection task. J Neurosci 27: 8122-8137, 2007.
28. Parker AJ, Newsome WT. Sense and the single neuron: probing the physiology of perception. Annu Rev Neurosci 21: 227-277, 1998.
29. Price NS, Born RT. Timescales of sensory-and decision-related activity in the middle temporal and medial superior temporal areas. J Neurosci 30: 14036-14045, 2010.
30. Purushothaman G, Bradley DC. Neural population code for fine perceptual decisions in area MT. Nat Neurosci 8: 99-106, 2005.
31. Rao V, DeAngelis GC, Snyder LH. Neural correlates of prior expectations of motion in the lateral intraparietal and middle temporal areas. J Neurosci 32: 10063-10074, 2012.
32. Rieke F, Warland D, de Ruyter van Steveninck RR, Bialek W. Spikes: Exploring the Neural Code. Cambridge, MA: MIT Press, 1997.
33. Robinson DA. A method of measuring eye movement using a scleral search coil in a magnetic field. IEEE Trans Biomed Eng 10: 137-145, 1963.
34. Russ BE, Orr LE, Cohen YE. Prefrontal neurons predict choices during an auditory same-different task. Curr Biol 18: 1483-1488, 2008.
35. Sasaki R, Uka T. Dynamic readout of behaviorally relevant signals from area MT during task switching. Neuron 62: 147-157, 2009.
36. Shadlen MN, Britten KH, Newsome WT, Movshon JA. A computational analysis of the relationship between neuronal and behavioral responses to visual motion. J Neurosci 16: 1486-1510, 1996.
37. Smith MA, Kelly RC, Lee TS. Dynamics of response to perceptual pop-out stimuli in macaque V1. J Neurophysiol 98: 3436-3449, 2007.
38. Smith JE, Zhan CA, Cook EP. The functional link between area MT neural fluctuations and detection of a brief motion stimulus. J Neurosci 31: 13458-13468, 2011.
39. Tolhurst DJ, Movshon JA, Dean AF. The statistical reliability of signals in single neurons in cat and monkey visual cortex. Vision Res 23: 775-785, 1983.
40. Uka T, DeAngelis GC. Contribution of middle temporal area to coarse depth discrimination: comparison of neuronal and psychophysical sensitivity. J Neurosci 23: 3515-3530, 2003.
41. Uka T, DeAngelis GC. Contribution of area MT to stereoscopic depth perception: choice-related response modulations reflect task strategy. Neuron 42: 297-310, 2004.
42. Uka T, Tanabe S, Masayuki W, Fujita I. Neural correlates of fine depth discrimination in monkey inferior temporal cortex. J Neurosci 25: 10796-10802, 2005.
43. Verhoef BE, Vogels R, Janssen P. Contribution of inferior temporal and posterior parietal activity to three-dimensional shape perception. Curr Biol 20: 909-913, 2010.
44. Williams ZM, Elfar JC, Eskandar EN, Toth LJ, Assad JA. Parietal activity and the perceived direction of ambiguous apparent motion. Nat Neurosci 6: 616-623, 2003.
45. Wolbarsht ML, MacNichol EF, Wagner HG. Glass insulated platinum microelectrode. Science 132: 1309-1310, 1960.
46. Zohary E, Hilman P, Hochstein S. Time course of perceptual discrimination and single neuron reliability. Biol Cybern 62: 475-486, 1990.