Home ovulation tests and stress in women trying to conceive: A randomized controlled trial

Human Reproduction

Volumn 28, Issue 1, 2013, Pages 138-151

  Tiplady, S ^a   Jones, G ^b   Campbell, M ^b   Johnson, S ^a   Ledger, W ^c  

^a SPD Development Company Limited   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

cortisol; ovulation tests; questionnaire; stress; timed intercourse

Indexed keywords

HYDROCORTISONE;

ADULT; ARTICLE; CONCEPTION; CONTROLLED STUDY; FEMALE; FERTILE PERIOD; HOME OVULATION TEST; HUMAN; HYDROCORTISONE URINE LEVEL; MENSTRUAL CYCLE; OVULATION; PROCEDURES; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SEXUAL INTERCOURSE; STRESS; WELLBEING;

EID: 84871252370     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/des372     Document Type: Article

References (54)

1. American Society for Reproductive Medicine (ASRM) Practice Committee. Definition of 'infertility'. Fertil Steril 2006;86(Suppl 4):S228.
2. Anderheim L, Holter H, Bergh C, Moller A. Does psychological stress affect the outcome of in vitro fertilization? Hum Reprod 2005;20:2969-2975.
3. Behre H, Kuhlage J, Gasner C, Sonntag B, Schem C, Schneider H, Nieschlag E. Prediction of ovulation by urinary hormone measurements with the home use ClearPlan Fertility Monitor: comparison with transvaginal ultrasound scans and serum hormone measurements. Hum Reprod 2000;15:2478-2482.
4. Blackwell LF, Brown JB, Vigil P, Gross B, Sufi S, d'Arcangues C. Hormonal monitoring of ovarian activity using the ovarian monitor, Part 1. Validation of home and laboratory results obtained during ovulatory cycles by comparison with radioimmunoassay. Steroids 2003;68:465-476.
5. Boivin J, Lancastle D. Medical waiting periods: imminence, emotions and coping. Women's Health 2010;6:59-69.
6. Boivin J, Takefman J. Stress level across stages of in vitro fertilisation in subsequently pregnant and nonpregnant women. Fertil Steril 1995; 64:802-810.
7. Boivin J, Takefman J, Brender W, Tulandi T. The effects of female sexual response in coitus on early reproductive processes. J Behav Med 1992; 15:509-518.
8. Boivin J, Bunting L, Collins J, Nygren G. International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care. Hum Reprod 2007;22:1506-1512.
9. Boivin J, Griffiths E, Venetis C. Emotional distress in infertile women and failure of assisted reproductive technologies: meta-analysis of prospective psychosocial studies. Br Med J 2011;342(d223):1-9.
10. Brown J, Blackwell L, Billings J, Conway B, Cox R, Garrett G, Holmes J, Smith M. Natural family planning. Am J Obstet Gynecol 1987;157: 1082-1089.
11. Buck Louis G, Lum K, Sundaram R, Chen Z, Kim S, Lynch C, Schisterman E, Pyper C. Stress reduces conception probabilities across the fertile window: evidence in support of relaxation. Fertil Steril 2011;95:2184-2189.
12. Bunting L, Boivin J. Decision-making about seeking medical advice in an internet sample of women trying to get pregnant. Hum Reprod 2007; 22:1662-1668.
13. Cohen S, Williamson G. Perceived stress in a probability sample of the United States. In: Spacapan S, Scamp S (eds). The Social Psychology of Health: Claremont Symposium on Applied Social Psychology. Newbury Park, CA: Sage Publications, 1998, 31-67.
14. Cohen S, Kamarch T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav 1983;24:385-396.
15. Collins W. Hormonal indices of ovulation and the fertile period. Adv Contracept 1985;1:279-294.
16. Connolly K, Edelmann R, Bartlett H, Cooke I, Lenton E, Pike S. An evaluation of counselling for couples undergoing treatment for in-vitro fertilisation. Hum Reprod 1993;8:1332-1338.
17. Crawford J, Henry J. The positive and negative affect schedule (PANAS): construct validity, measurement properties and normative data in large a large non-clinical sample. Br J Clin Psychol 2004; 43:245-265.
18. Creinin M, Keverline Sand Meyn L. How regular is regular? An analysis of menstrual cycle regularity. Contraception 2004;70:289-292.
19. Drake T, Grunert G. A cyclic pattern of sexual dysfunction in the fertility investigation. Fertil Steril 1979;32:542-545.
20. Gnoth C, Frank-Herrmann P, Freundl G. Opinion: natural family planning and the management of infertility. Arch Gynecol Obstet 2002; 267:67-71.
21. Hilgers T, Daly K, Prebil A, Hilgers S. Cumulative pregnancy rates in patients with apparently normal fertility and fertility-focused intercourse. J Reprod Med 1992;37:864-866.
22. Hjollund N, Jenson T, Bonde J, Henriksen T, Andersson A, Kolstad H, Skakkebaek N, Olsen J. Distress and reduced fertility: a follow-up study of first-pregnancy planners. Fertil Steril 1999;72:47-53.
23. Jenkinson C, Stewart-Brown S, Peterson S, Paice C. Assessment of the SF-36 version 2 in the United Kingdom. J Epidemiol Community Health 1999;53:46-50.
24. Johnson S, Miro F, Barrett S, Ellis J. Levels of urinary human chorionic gonadotrophin (hCG) following conception and variability of menstrual cycle length in a cohort of women attempting to conceive. Curr Med Res Opin 2009;25:741-748.
25. Johnson S, Ellis J, Godbert S, Ali S, Zinaman M. Comparison of a digital ovulation test with three popular line ovulation tests to investigate user accuracy and certainty. Expert Opin Med Diagn 2011;5:467-473.
26. Kopitzke E, Berg B, Wilson J, Owens D. Physical and emotional stress associated with components of the infertility investigation: perspectives of professionals and patients. Fertil Steril 1991;55:1137-1143.
27. Lokuge S, Frey B, Foster J, Soares C, Steiner M. Depression in women: windows of vulnerability and new insights into the link between estrogen and serotonin. J Clin Psychiatry 2011;72: e1563-e1569.
28. Lynch C, Sundaram R, Buck-Louis G, Lum K, Pyper C. Are increased levels of self-reported psychosocial stress, anxiety, and depression associated with fecundity? Fertil Steril 2012;98:453-458.
29. Marshall C, Rossman G. Designing Qualitative Research, 3rd edn. London: Sage, UK, 1999.
30. Mathews T, Hamilton B. 2009. Delayed childbearing: more women are having their first child later in life. NCHS Data Brief 21 [online] Available at:, http://www. cdc. gov/nchs/data/databriefs/db21. pdf. (10 August 2012, date last accessed).
31. Matthews JNS, Altman DG, Campbell MJ, Royston P. Analysis of serial measurements in medical research. Br Med J 1990;300:230-235.
32. Miki K, Sudo A. Effect of urine pH, storage time and temperature on stability of catecholamines, cortisol and creatinine. Clin Chem 1998; 44:1759-1762.
33. Milad M, Klock S, Moses S, Chatterton R. Stress and anxiety do not result in pregnancy wastage. Hum Reprod 1998;13:2296-2300.
34. Miro F, Parker S, Aspinall L, Coley J, Perry P, Ellis J. Sequential classification of endocrine stages during reproductive aging in women: the FREEDOM study. Menopause 2005;12:281-290.
35. Nakamura K, Sheps S, Arck P. Stress and reproductive failure: past notions, present insights and future directions. J Assist Reprod Genet 2008;25:47-62.
36. National Institute for Clinical Excellence (NICE) Clinical Guideline 2004. Fertility: assessment and treatment for people with fertility problems. [online] Available at. http://publications. nice. org. uk/fertility-cg11. (13 March 2012, date last accessed).
37. Nepomnaschy P, Altman R, Watterson R, Co C, McConnell D, England B. Is cortisol excretion independent of menstrual cycle day? A longitudinal evaluation of first morning urinary specimens. PLoS ONE 2011;6:e18242.
38. Nicolson N. Measurement of cortisol. In: Luecken L, Gallo L (eds). Handbook of Physiological Research Methods in Health Psychology. Thousand Oaks, CA: Sage Publications, 2008, 37-74.
39. Office for National Statistics (ONS). 2010. Live births in England and Wales by characteristics of mother 2010. [online] Available at:, http://www. ons. gov. uk/ons/index. html. (13 March 2012, date last accessed).
40. Robinson J, Ellis J. Mistiming of intercourse as a primary cause of failure to conceive: results of a survey on use of a home-use fertility monitor. Curr Med Res Opin 2007;23:301-306.
41. Robinson J, Wakelin M, Ellis J. Increased pregnancy rate with use of the Clearblue Easy Fertility Monitor. Fertil Steril 2007;87:329-334.
42. Sanders K, Bruce N. A prospective study of psychosocial stress and fertility in women. Hum Reprod 1997;12:2324-2329.
43. Schmidt L, Sobotka T, Bentzen J, Andersen A. Demographic and medical consequences of the postponement of parenthood. Hum Reprod Update 2011;18:29-43.
44. Severy L, Robinson J, Findley-Klein C, McNulty J. Acceptability of a home monitor used to aid in conception: psychosocial factors and couple dynamics. Contraception 2006;73:65-71.
45. Sheiner E, Sheiner E, Potashnik G, Carel R, Shoham-Vardi I. The relationship between occupational psychological stress and female fertility. Occup Med 2003;53:265-269.
46. Singh M, Baxena B, Rathnam P. Clinical validation of enzyme immunoassay of human luteinizing hormone (hLH) in the detection of the pre-ovulatory luteinizing hormone (LH) surge in urine. Fertil Steril 1984;41:210-217.
47. Small C, Manatunga A, Marcus M. Validity of self-reported menstrual cycle length. Ann Epidemiol 2007;17:163-170.
48. Stanford J, White G, Hatasaka H. Timing intercourse to achieve pregnancy: current evidence. Obstet Gynecol 2002;100:1333-1341.
49. Takefman J, BrenderW, Boivin J, Tulandi T. Sexual and emotional adjustment of couples undergoing infertility investigation and the effectiveness of preparatory information. J Psychosom Obstet Gynecol 1990;11:275-290.
50. Ware J, Sherbourne C. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 1992; 30:473-483.
51. Watson D, Clark L, Tellegen A. Development and validation of brief measures of positive and negative affect: the PANAS scales. J Pers Soc Psychol 1988;54:1063-1070.
52. WHO Task force on Methods for Determination of the Fertile Period. Temporal relationships between ovulation and defined changes in the concentration of plasma estradiol-17b, luteinising hormone, follicle stimulating hormone and progesterone. I. Probit analysis. Am J Obstet Gynaecol 1980;138:383-390.
53. Wilcox A, Dunson D, Baird D. The timing of the 'fertile window' in the menstrual cycle: day specific estimates from a prospective study. Br Med J 2000;321:1259-1262.
54. Zinaman M, Johnson S, Ellis J, LedgerW. Accuracy of perception of ovulation day in women trying to conceive. Curr Med Res Opin 2012;28:1-6.