Can inhA mutation predict ethionamide resistance?

International Journal of Tuberculosis and Lung Disease

Volumn 17, Issue 1, 2013, Pages

  Vadwai, V ^a   Ajbani, K ^a   Jose, M ^a   Vineeth, V P ^a   Nikam, C ^a   Deshmukh, M ^a   Shetty, A ^a   Soman, R ^a   Rodrigues, Camilla ^a  

^a P D HINDUJA NATIONAL HOSPITAL   (India)

Author keywords

Drug resistance; Ethionamide; inhA mutation; Isoniazid; Phenotypic drug susceptibility testing

Indexed keywords

ETHIONAMIDE; ISONIAZID;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM MUTANT; CONTROLLED STUDY; DISEASE MARKER; DRUG SENSITIVITY; GENE MUTATION; INDIA; INHA GENE; LABORATORY TEST; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROMOTER REGION;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; ETHIONAMIDE; HUMANS; MICROBIAL SENSITIVITY TESTS; MUTATION; MYCOBACTERIUM TUBERCULOSIS; OXIDOREDUCTASES;

EID: 84871239701     PISSN: 10273719     EISSN: None     Source Type: Journal    
DOI: 10.5588/ijtld.12.0511     Document Type: Article

References (8)

1. Central TB Division, Ministry of Health and Family Welfare. Revised National Tuberculosis Control Program: DOTS-Plus guidelines. New Delhi, India: Ministry of Health and Family Welfare, 2010.
2. World Health Organization. Policy guideline on drug susceptibility testing (DST) of second-line anti-tuberculosis drugs. WHO/TB/2008.392. Geneva, Switzerland: WHO, 2008.
3. Baulard A R, Betts J C, Engohang-Ndong J, et al. Activation of the pro-drug ethionamide is regulated in mycobacteria. J Biol Chem 2000; 275: 28326-28331.
4. Zhang Y, Heym B, Allen B, et al. The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis. Nature 1992; 358: 591-593.
5. de Silva P E A, Palomino J C. Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs. J Antimicrob Chemother 2011; 66: 1417-1430.
6. Rodrigues C, Jani J, Shenai S, et al. Drug susceptibility testing of Mycobacterium tuberculosis against second-line drugs using the BACTEC MGIT 960 system. Int J Tuberc Lung Dis 2008; 12: 1449-1455.
7. Lee H, Cho S N, Bang H E, et al. Exclusive mutations related to isoniazid and ethionamide resistance among Mycobacterium tuberculosis isolates from Korea. Int J Tuberc Lung Dis 2000; 4: 441-447. (Pubitemid 30256847)
8. Lavender C, Globan M, Sievers A, et al. Molecular characterization of Mycobacterium tuberculosis isoniazid-resistant isolates collected in Australia. Antimicrob Agents Chemother 2005; 49: 4068-4074. (Pubitemid 41400948)