The role of inhaled corticosteroids in management of asthma in infants and preschoolers

Current Opinion in Pulmonary Medicine

Volumn 19, Issue 1, 2013, Pages 54-59

  Castro Rodriguez, Jose A ^a   Pedersen, Soren ^b  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

asthma; infants; inhaled corticosteroids; preschoolers; treatment

Indexed keywords

BECLOMETASONE DIPROPIONATE; BUDESONIDE; CORTICOSTEROID; FLUTICASONE PROPIONATE; MONTELUKAST; PLACEBO; SALBUTAMOL;

ASTHMA; BODY GROWTH; BODY HEIGHT; CANDIDIASIS; CHILD; CLINICAL TRIAL (TOPIC); CONTROLLED CLINICAL TRIAL (TOPIC); CORTICOSTEROID THERAPY; DOSE RESPONSE; DRUG MEGADOSE; EVENING DOSAGE; HOARSENESS; HUMAN; INFANT; MAINTENANCE THERAPY; PATIENT SAFETY; PRESCHOOL CHILD; REVIEW; SIDE EFFECT; SYSTEMATIC REVIEW; UPPER RESPIRATORY TRACT INFECTION; WEIGHT GAIN; WHEEZING;

ADMINISTRATION, INHALATION; ADRENAL CORTEX HORMONES; ASTHMA; CHILD, PRESCHOOL; DISEASE MANAGEMENT; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INFANT; TREATMENT OUTCOME;

EID: 84871237893     PISSN: 10705287     EISSN: 15316971     Source Type: Journal    
DOI: 10.1097/MCP.0b013e32835b1165     Document Type: Review

References (42)

1. Yunginger JW, Reed CE, O'Connell EJ, et al. A community-based study of the epidemiology of asthma. Incidence rates, 1964-1983. Am Rev Respir Dis 1992; 146:888-894.
2. Heikkinen T, Jarvinen A. The common cold. Lancet 2003; 361:51-59.
3. Martinez FD, Wright AL, Taussig LM, et al. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med 1995; 332:133-138.
4. Henderson J, Granell R, Heron J, et al. Associations of wheezing phenotypes in the first 6 years of life with atopy, lung function and airway responsiveness in mid-childhood. Thorax 2008; 63:974-980.
5. Savenije OE, Granell R, Caudri D, et al. Comparison of childhood wheezing phenotypes in 2 birth cohorts: ALSPAC and PIAMA. J Allergy Clin Immunol 2011; 127:1505-1512.
6. Spycher BD, Silverman M, Brooke AM, et al. Distinguishing phenotypes of childhood wheeze and cough using latent class analysis. Eur Respir J 2008; 31:974-978.
7. Smith JA, Drake R, Simpson A, et al. Dimensions of respiratory symptoms in preschool children: population-based birth cohort study. Am J Respir Crit Care Med 2008; 177:1358-1363.
8. Bhatt JM, Smyth AR. The management of preschool wheeze. Paediatr Respir Rev 2011; 12:70-77.
9. Brand PL, Baraldi E, Bisgaard H, et al. Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach. Eur Respir J 2008; 32:1096-1110.
10. Schultz A, Brand PL. Episodic viral wheeze and multiple trigger wheeze in preschool children: a useful distinction for clinicians? Paediatr Respir Rev 2011; 12:160-164.
11. Garcia-Marcos L, Martinez FD. Multitrigger versus episodic wheeze in toddlers: new phenotypes or severity markers? J Allergy Clin Immunol 2010; 126:489-490.
12. Schultz A, Devadason SG, Savenije OE, et al. The transient value of classifying preschool wheeze into episodic viral wheeze and multiple trigger wheeze. Acta Paediatr 2010; 99:56-60.
13. Pedersen S. Preschool asthma-not so easy to diagnose. Prim Care Respir J 2007; 16:4-6.
14. Rodriguez-Martinez CE, Sossa-Briceno MP, Castro-Rodriguez JA. Discriminative properties of two predictive indices for asthma diagnosis in a sample of preschoolers with recurrent wheezing. Pediatr Pulmonol 2011;46:1175-1181.
15. Castro-Rodriguez JA, Holberg CJ, Wright AL, Martinez FD. A clinical index to define risk of asthma in young children with recurrent wheezing. Am J Respir Crit Care Med 2000; 162 (4 Pt 1):1403-1406.
16. Kurukulaaratchy RJ, Matthews S, Holgate ST, Arshad SH. Predicting persistent disease among children who wheeze during early life. Eur Respir J 2003; 22:767-771.
17. Caudri D, Wijga A, A Schipper CM, et al. Predicting the long-term prognosis of children with symptoms suggestive of asthma at preschool age. J Allergy Clin Immunol 2009; 124:903-910.
18. Pedersen S, Hurd SS, Lemanske RF, et al. Global strategy for the diagnosis and management of asthma in children 5 years and younger (GINA). Pediatr Pulmonol 2011; 46:1-17.
19. National Heart, Lung, and Blood Institute, National Asthma Education and Prevention Program. Expert Panel Report 3 (EPR 3): guidelines for the diagnosis and management of asthma 2007. http://www.nhlbi.nih.gov/guide lines/asthma/asthgdln.htm. [Accessed 1 July 2012]
20. Castro-Rodriguez JA, Rodriguez-Martinez CE, Custovic A. Infantile and preschool asthma. Eur Respir Monogr 2012; 56:10-21.
21. Wilson N, Sloper K, Silverman M. Effect of continuous treatment with topical corticosteroid on episodic viral wheeze in preschool children. Arch Dis Child 1995; 72:317-320.
22. Bisgaard H, Allen D, Milanowski J, et al. Twelve-month safety and efficacy of inhaled fluticasone propionate in children aged 1 to 3 years with recurrent wheezing. Pediatrics 2004; 113:e87-e94.
23. Wasserman RL, Baker JW, Kim KT, et al. Efficacy and safety of inhaled fluticasone propionate chlorofluorocarbon in 2-to 4-year-old patients with asthma: results of a double-blind, placebo-controlled study. Ann Allergy Asthma Immunol 2006; 96:808-818.
24. Chavasse RJ, Bastian-Lee Y, Richter H, et al. Persistent wheezing in infants with an atopic tendency responds to inhaled fluticasone. Arch Dis Child 2001; 85:143-148.
25. Guilbert TW, Morgan WJ, Zeiger RS, et al. Long-term inhaled corticosteroids in preschool childrenat high risk for asthma. Nengl J Med 2006;354:1985-1997.
26. Brand PL, Luz García-Garćia M, Morison A, et al. Ciclesonide in wheezy preschool children with a positive asthma predictive index or atopy. Respir Med 2011; 105:1588-1595.
27. Kooi EM, Schokker S, Marike Boezen H, et al. Fluticasone or montelukast for preschool children with asthma-like symptoms: randomized controlled trial. Pulm Pharmacol Ther 2008; 21:798-880.
28. Castro-Rodriguez JA, Rodrigo GJ. Efficacy of inhaled corticosteroids in infants and preschoolers with recurrent wheezing and asthma: a systematic review with meta-analysis. Pediatrics 2009; 123:e519-e525.
29. Ducharme FM, Lemire C, Noya FJ, et al. Preemptive use of high-dose fluticasone for virus-induced wheezing in young children. N Engl J Med 2009; 360:339-353.
30. Svedmyr J, Nyberg E, Thunqvist P, et al. Prophylactic intermittent treatment with inhaled corticosteroids of asthma exacerbations due to airway infections in toddlers. Acta Paediatr 1999; 88:42-47.
31. Wilson NM, Silverman M. Treatment of acute, episodic asthma in preschool children using intermittent high dose inhaled steroids at home. Arch Dis Child 1990; 65:407-410.
32. Connett G, Lenney W. Prevention of viral induced asthma attacks using inhaled budesonide. Arch Dis Child 1993; 68:85-87.
33. Bacharier LB, Phillips BR, Zeiger RS, et al. Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing. J Allergy Clin Immunol 2008; 122:1127-1135.
34. Papi A, Nicolini G, Boner AL, et al. Short term efficacy of nebulized beclomethasone in mild-to-moderate wheezing episodes in preschool children. Ital J Pediatr 2011; 37:39.
35. Zeiger RS, Mauger D, Bacharier LB, et al. Daily or intermittent budesonide in preschool children with recurrent wheezing. N Engl J Med 2011; 365:1990-2001.
36. Pedersen S. State of the art: inhaled steroids and growth in children. Am J Respir Crit Care Med 2001; 163:521-535.
37. Pedersen S, Dubus JC, Crompton G. Inhaler selection in children with asthma. Prim Care Respir J 2010; 19:209-216.
38. Bisgaard H. Systemic activity of inhaled topical steroid in toddlers studied by knemometry. Acta Paediatr 1993; 82:1066-1071.
39. Anhøj J, Bisgaard AM, Bisgaard H. Systemic activity of inhaled steroids in 1-to 3-year-old children with asthma. Pediatrics 2002; 109:E40.
40. Pedersen S. Do inhaled corticosteroids inhibit growth in children? Am J Respir Crit Care Med 2001; 164:521-535.
41. Baker JW, Mellon M, Wald J, et al. A multiple-dosing, placebo-controlled study of budesonide inhalation suspension given once or twice daily for treatment of persistent asthma in young children and infants. Pediatrics 1999; 103:414-421.
42. Quak W, Klok T, Kaptein AA, et al. Preschool children with high adherence to inhaled corticosteroids for asthma do not show behavioural problems. Acta Paediatr 2012; 101:1156-1160.