Insula-specific H magnetic resonance spectroscopy reactions in heavy smokers under acute nicotine withdrawal and after oral nicotine substitution

European Addiction Research

Volumn 19, Issue 4, 2013, Pages 184-193

  Gutzeit, Andreas ^a,g   Froehlich, Johannes M ^a   Hergan, Klaus ^g   Graf, Nicole ^a   Binkert, Christoph A ^a   Meier, Dieter ^b   Brügger, Mike ^b   Reischauer, Carolin ^a   Sutter, Reto ^c   Herdener, Marcus ^d   Schubert, Tillmann ^e   Kos, Sebastian ^e   Grosshans, Martin ^f   Straka, Matus ^a   Mutschler, Jochen ^d  

^a CANTONAL HOSPITAL WINTERTHUR   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c BALGRIST UNIVERSITY HOSPITAL   (Switzerland)

^d UNIVERSITY HOSPITAL OF PSYCHIATRY   (Switzerland)

^e UNIVERSITY OF BASEL   (Switzerland)

^f UNIVERSITY OF HEIDELBERG   (Germany)

^g PARACELSUS MEDICAL UNIVERSITY   (Austria)

Author keywords

Insular cortex; Magnetic resonance spectroscopy; Nicotine; Nicotine withdrawal; Smoking addiction

Indexed keywords

CARBON MONOXIDE; GLUTAMIC ACID; GLUTAMINE; INOSITOL; NICOTINE; ALANINE; ASPARTIC ACID; CHOLINE; CREATINE; LACTIC ACID; N ACETYLASPARTIC ACID; NICOTINE GUM;

ADULT; ARTICLE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG SUBSTITUTION; EXPIRED AIR; HUMAN; HYPOTHESIS; INSULA; MALE; METABOLITE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTON NUCLEAR MAGNETIC RESONANCE; SMOKING; TOBACCO DEPENDENCE; WITHDRAWAL SYNDROME; BREATH ANALYSIS; MIDDLE AGED; NICOTINE REPLACEMENT THERAPY; NUCLEAR MAGNETIC RESONANCE SCANNER; SMOKING CESSATION;

ADMINISTRATION, ORAL; ADULT; BEHAVIOR, ADDICTIVE; CARBON MONOXIDE; CASE-CONTROL STUDIES; CEREBRAL CORTEX; FUNCTIONAL NEUROIMAGING; GLUTAMIC ACID; GLUTAMINE; HUMANS; INOSITOL; MALE; MIDDLE AGED; NICOTINE; SMOKING; SUBSTANCE WITHDRAWAL SYNDROME; TOBACCO USE CESSATION PRODUCTS;

EID: 84871216205     PISSN: 10226877     EISSN: 14219891     Source Type: Journal    
DOI: 10.1159/000345915     Document Type: Article

References (45)

1. Ezzati M, Lopez AD: Measuring the accumulated hazards of smoking: global and regional estimates for 2000. Tob Control 2003; 12: 79-85. (Pubitemid 39456695)
2. Grant BF, Hasin DS, Chou SP, Stinson FS, Dawson DA: Nicotine dependence and psychiatric disorders in the United States: results from the national epidemiologic survey on alcohol and related conditions. Arch Gen Psychiatry 2004; 61: 1107-1115. (Pubitemid 39463411)
3. Murray CJ, Lopez AD: Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. Lancet 1997; 349: 1498-1504. (Pubitemid 27216360)
4. WHO EMRO. Tobacco Free Initiative facts and FAQs. http://www.emro.who. int/tfi/facts.htm (accessed May 15, 2012).
5. Cosci F, Pistelli F, Lazzarini N, Carrozzi L: Nicotine dependence and psychological distress: outcomes and clinical implications in smoking cessation. Psychol Res Behav Manag 2011; 4: 119-128.
6. Benowitz NL: Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics. Annu Rev Pharmacol Toxicol 2009; 49: 57-71.
7. Malaiyandi V, Sellers EM, Tyndale RF: Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence. Clin Pharmacol Ther 2005; 77: 145-158. (Pubitemid 40269130)
8. Ringlever L, Otten R, de Leeuw RN, Engels RC: Effects of parents' education and occupation on adolescent smoking and the mediating role of smoking-specific parenting and parent smoking. Eur Addict Res 2011; 17: 55-63.
9. Mutschler J, Abbruzzese E, von der Goltz C, Dinter C, Mobascher A, Thiele H, Diaz-Lacava A, Dahmen N, Gallinat J, Majic T, Petrovsky N, Kornhuber JN, Thuerauf N, Gründer G, Brinkmeyer J, Wienker T, Wagner M, Winterer G, Kiefer F: Genetic variation in the neuropeptide Y gene promoter is associated with increased risk of tobacco smoking. Eur Addict Res 2012; 18: 246-252.
10. Brody AL, Mandelkern MA, Jarvik ME, Lee GS, Smith EC, Huang JC, Bota RG, Bartzokis G, London ED: Differences between smokers and nonsmokers in regional gray matter volumes and densities. Biol Psychiatry 2004; 55: 77-84. (Pubitemid 38045436)
11. Zhang X, Salmeron BJ, Ross TJ, Geng X, Yang Y, Stein EA: Factors underlying prefrontal and insula structural alterations in smokers. Neuroimage 2011; 54: 42-48.
12. Kurth F, Zilles K, Fox PT, Laird AR, Eickhoff SB: A link between the systems: functional differentiation and integration within the human insula revealed by meta-analysis. Brain Struct Funct 2010; 214: 519-534.
13. Naqvi NH, Rudrauf D, Damasio H, Bechara A: Damage to the insula disrupts addiction to cigarette smoking. Science 2007; 26: 315: 531-534. (Pubitemid 46175760)
14. Wittchen HU, Zaudig, M, Fydrich T: SKID. Strukturiertes Klinisches Interview fuer DSM-IV. Achse I und II. Handanweisung. Göttingen, Hogrefe, 1997.
15. Schumann A, Rumpf HJ, Meyer C, Hapke U, John U: Deutsche Version des Fagerström-Test for Nicotine Dependence (FTND-G) und des Heaviness of Smoking Index (HSIG); in Glöckner-Rist A, Rist F, Küfner H (eds): Elektronisches Handbuch zu Erhebungsinstrumenten im Suchtbereich (EHES), version 3.00. Mannheim, Zentrum für Umfragen, Methoden und Analysen, 2003.
16. Heatherton TF, Kozlowski LT, Frecker RC, Fagerström KO: The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. Br J Addict 1991; 86: 1119-1127.
17. Tiffany ST, Drobes DJ: The development and initial validation of a questionnaire on smoking urges. Br J Addict 1991; 86: 1467-1476.
18. Mueller V, Mucha RF, Ackermann K: The assessment of craving in smokers with a German version of the 'Questionnaire on Smoking Urges' (QSUG). Z Klin Psychol Psychother 2001; 30: 164-171. (Pubitemid 33121562)
19. Hughes JR, Hatsukami D: Signs and symptoms of tobacco withdrawal. Arch Gen Psychiatry 1986; 43: 289-294. (Pubitemid 16052281)
20. Provencher SW: Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 1993; 30: 672-679. (Pubitemid 23360802)
21. World Health Organization: The ICD-10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research. F10-F19. http://www.who.int/substance-abuse/terminology/ICD10ResearchDiagnosis. pdf (accessed May 15, 2011).
22. D'Souza MS, Markou A: Neuronal mechanisms underlying development of nicotine dependence: implications for novel smoking-cessation treatments. Addict Sci Clin Pract 2011; 6: 4-16.
23. D'Souza MS, Markou A: Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats. Neuropharmacology 2011; 61: 1399-1405.
24. Mullins ME: MR spectroscopy: truly molecular imaging; past, present and future. Neuroimaging Clin N Am 2006; 16: 605-618. (Pubitemid 44828757)
25. Petrou M, Harris RE, Foerster BR, McLean SA, Sen A, Clauw DJ, Sundgren PC: Proton MR spectroscopy in the evaluation of cerebral metabolism in patients with fibromyalgia: comparison with healthy controls and correlation with symptom severity. AJNR Am J Neuroradiol 2008; 29: 913-918. (Pubitemid 351684966)
26. Hasler G, van der Veen JW, Grillon C, Drevets WC, Shen J: Effect of acute psychological stress on prefrontal GABA concentration determined by proton magnetic resonance spectroscopy. Am J Psychiatry 2010; 167: 1226-1231.
27. Hermann D, Frischknecht U, Heinrich M, Hoerst M, Vollmert C, Vollstädt-Klein S, Tunc-Skarka N, Kiefer F, Mann K, Ende G: MR spectroscopy in opiate maintenance therapy: association of glutamate with the number of previous withdrawals in the anterior cingulate cortex. Addict Biol 2012; 17: 659-667.
28. Hermann D, Sartorius A, Welzel H, Walter S, Skopp G, Ende G, Mann K: Dorsolateral prefrontal cortex N-acetylaspartate/total creatine (NAA/tCr) loss in male recreational cannabis users. Biol Psychiatry 2007; 61: 1281-1289. (Pubitemid 46726261)
29. Umhau JC, Momenan R, Schwandt ML, Singley E, Lifshitz M, Doty L, Adams LJ, Vengeliene V, Spanagel R, Zhang Y, Shen J, George DT, Hommer D, Heilig M: Effect of acamprosate on magnetic resonance spectroscopy measures of central glutamate in detoxified alcohol-dependent individuals: a randomized controlled experimental medicine study. Arch Gen Psychiatry 2010; 67: 1069-1077.
30. Gutzeit A, Meier D, Meier ML, von Weymarn C, Ettlin DA, Graf N, Froehlich JM, Binkert CA, Brügger M: Insula-specific responses induced by dental pain. A proton magnetic resonance spectroscopy study. Eur Radiol 2011; 21: 807-815.
31. Gutzeit A, Meier D, Froehlich JM, Hergan K, Kos S, V Weymarn C, Lutz K, Ettlin D, Binkert CA, Mutschler J, Sartoretti-Schefer S, Brügger M: Differential NMR spectroscopy reactions of anterior/posterior and right/left insular subdivisions due to acute dental pain. Eur Radiol 2012, E-pub ahead of print.
32. Sidoryk-Wegrzynowicz M, Wegrzynowicz M, Lee E, Bowman AB, Aschner M: Role of astrocytes in brain function and disease (review). Toxicol Pathol 2011; 39: 115-123
33. Hermann D, Weber-Fahr W, Sartorius A, Hoerst M, Frischknecht U, Tunc-Skarka N, Perreau-Lenz S, Hansson AC, Krumm B, Kiefer F, Spanagel R, Mann K, Ende G, Sommer WH: Translational magnetic resonance spectroscopy reveals excessive central glutamate levels during alcohol withdrawal in humans and rats. Biol Psychiatry 2012; 71: 1015-1021.
34. Magistretti PJ, Pellerin L: Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging. Philos Trans R Soc Lond B Biol Sci 1999; 354: 1155-1163. (Pubitemid 29400898)
35. Novotny EJ Jr, Fulbright RK, Pearl PL, Gibson KM, Rothman DL: Magnetic resonance spectroscopy of neurotransmitters in human brain. Ann Neurol 2003; 54(suppl 6):25-31.
36. Mangia S, Giove F, Tkác I, Logothetis NK, Henry PG, Olman CA, Maraviglia B, Di Salle F, U?urbil K: Metabolic and hemodynamic events after changes in neuronal activity: current hypotheses, theoretical predictions and in vivo NMR experimental findings. J Cereb Blood Flow Metab 2009; 29: 441-463.
37. Bélanger M, Allaman I, Magistretti PJ: Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. Cell Metab 2011; 14: 724-738.
38. Chen WJ, Edwards RB, Romero RD, Parnell SE, Monk RJ: Long-term nicotine exposure reduces Purkinje cell number in the adult rat cerebellar vermis. Neurotoxicol Teratol 2003; 25: 329-334. (Pubitemid 36579183)
39. Domino EF: Tobacco smoking and MRI/MRS brain abnormalities compared to nonsmokers. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32: 1778-1781.
40. Craig AD: The sentient self. Brain Struct Funct 2010; 214: 563-577.
41. Baumgärtner U, Iannetti GD, Zambreanu L, Stoeter P, Treede RD, Tracey I: Multiple somatotopic representations of heat and mechanical pain in the operculo-insular cortex: a high-resolution fMRI study. J Neurophysiol 2010; 104: 2863-2872.
42. Craig AD: Interoception: the sense of the physiological condition of the body. Curr Opin Neurobiol 2003; 13: 500-505. (Pubitemid 37088242)
43. Lamm C, Singer T: The role of anterior insular cortex in social emotions. Brain Struct Funct 2010; 214: 579-591.
44. Singer T, Lamm C: The social neuroscience of empathy. Ann NY Acad Sci 2009; 1156: 81-96.
45. Phillips ML, Drevets WC, Rauch SL, Lane R: Neurobiology of emotion perception I: the neural basis of normal emotion perception. Biol Psychiatry 2003; 54: 504-514. (Pubitemid 37289437)